4 months ago I boasted of two papers accepted in two days. In the interests of transparency I should also post that this week we had two papers rejected (or stalled). I wish this process was a little less demoralising, it’s the most important thing we have to do!!! Be nice people!

Arriving at work. That’s the moon.

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...

Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...

Lab website has been updated including a very nice news section! Www.mcclellandlab.com/news

Ready to start your own independent research programme? We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk Apply by 27 Nov 2025: www.crick.ac.uk/careers-stud... #EarlyCareerResearchers #GroupLeader #ScienceCareers

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...

Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social

Last day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston! Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

Dosage responses of aneuploid autosomal chromosomes https://www.biorxiv.org/content/10.1101/2025.09.18.677044v1

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...

Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...

The ‘surprise baby’ of papers, we trained visiting lecturer from Thailand 🇹🇭 Raksawan, who co-led by @nadeemshaikh.bsky.social and @mollyguscott.bsky.social produced our first work investigating CIN in Cholangiocarcinoma (prevalent in Northern🇹🇭 ). Congrats to co-corr author @nadeemshaikh.bsky.social!

🎉 Join us in congratulating four BCI researchers who have been promoted! Promoted to Professor: 🔹Professor Angus Cameron 🔹Professor Jun Wang Promoted to Senior Lecturer: 🔹Dr Diu Nguyen Promoted to Reder: 🔹Dr Miguel Ganuza @qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social

Exciting work from my colleague Ben @benjaminwerner.bsky.social and others!

Calling all non-scientists interested in asking questions about cancer research for our new podcast-in-making!!! Please message your questions or contact me for more details 🤩

Very happy to share our work on signature SBS5. See Molly's thread for a short summary

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...

I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social. @anton-henssen.bsky.social @cancergrand.bsky.social aacrjournals.org/cancerdiscov...

We are looking for a postdoctoral researcher to investigate the role of inflammation on therapy resistance in colorectal cancer using patient-derived organoids and single-cell multiomics. Please reach out if interested: www.jobs.ac.uk/job/DNX776/p...

Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!

Prof Claude Chelala and her team's research into the inequalities facing women with breast cancer from different ancestries is now featured on @natcomms.nature.com homepage! Learn more & watch our interview with Prof Chelala: www.bci.qmul.ac.uk/general-news... #medsky 🧪 #oncosky @qmul.bsky.social

📰Could a breath test detect blood cancer? New research from @richeslab.bsky.social ‬funded by @bartscharity.bsky.social suggests molecules exhaled in the breath might enable development of a simple, low-cost test to diagnose lymphoma. @qmul.bsky.social @qmulfmd.bsky.social #medsky #oncosky 🧪

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...

Researchers have significantly expanded the catalogue of known human genetic variation. Two studies in @nature.com resequenced data from the landmark 1000 Genomes Project with long-read tech, creating what may be the most complete overview of the human genome to date. www.nature.com/articles/s41...

Two papers accepted in two days! I never thought I’d be one of those annoying people that says that kind of thing…..

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social! www.sciencedirect.com/science/arti...

I had a wonderful day at the Dunn school Oxford last Friday, met so many great scientists and trainees and got fantastic questions after my talk, thanks so much @esashilab.bsky.social for the invite, and hope to see you at BCI in the new year :)

There are just 3 days left on our crowd-investment campaign, which ends on Monday morning. Would you like to help us to get to the next round number? Every investment will help us to continue to achieve our aims... www.crowdcube.com/companies/ho...

Exploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models https://www.biorxiv.org/content/10.1101/2025.07.11.664318v1

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size (due to defects in cohesion and the mitotic checkpoint). Great work by fab PhD student Aanchal Pareri 👏🧪 www.biorxiv.org/content/10.1...

New preprint from Kelsey Fryer in the lab using ChAR-seq to identify RNAs that are bound to human centromeres. Lots of surprises! #centromere #RNA www.biorxiv.org/content/10.1...

Lab is quiet this week with 4 students/postdocs enjoying the science (and weather) at EACR in Lisbon!

Not many people know that I grew up in a folk music instrument shop that my parents established and grew into an international business. Times are tough and my sister (now managing director) has launched crowdfunding to help keep our music shops alive!. If anyone wants to support we’re grateful!