First time I give a talk literally in a football stadium 😎⚽️

Beautiful Bilbao

Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social

Great science and good fun at the faculty retreat of the Centre for Cancer Evolution @qmbci.bsky.social. Here @stuartmcdonald.bsky.social explaining his big question!

Peaceful early morning

Midsummer night 🌟🌙

This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...

Great meeting and great questions! Thanks for inviting me!

Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social

La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art

I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!

Street crossing in London, ON 🦆🦆🦆

Gorgeous day in NYC

Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social

Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...

Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.

We have two open positions for #computationalbiologists to work on: 1. Early cancer initiation following our work in #NatureCancer (Ref 5028) 2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073) To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...

Beautiful cover 😍 from an idea of our own @pedrandrei.bsky.social! Credits to Joe Brock from @crick.ac.uk

Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪

Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch @qmbci.bsky.social @ciccarellilab.bsky.social @drtanyasoliman.bsky.social @mcclellandlab.bsky.social @sibucz.bsky.social

Cool to be at #FoG2025 @fogenomics.bsky.social A bit more #SpatialGenomics content this year which is great! Surprise visit from #Darth & #Chewbacca! @ciccarellilab.bsky.social @mirjana-efremova.bsky.social @karlsmithbyrne.bsky.social @qmbci.bsky.social @omaiques.bsky.social

Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌

Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social

With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇

Strong Barts representation at the Cancer Research Nottingham Annual Symposium! @francesbalkwill.bsky.social @qmbci.bsky.social @uniofnottingham.bsky.social

Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert). Looking forward to working with you!

New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!

Sunrise in Islington

Nature Research Briefing asked us to explain our recent discovery (rdcu.be/d5pty) to a wider readership. The piece includes a comment from an external expert (thanks #StephenMeltzer, at #JohnHopkins!) and some "behind the paper" curiosities... www.nature.com/articles/s43...

Welcome @lambalastair.bsky.social to our Centre for Cancer Evolution @qmbci.bsky.social! Looking forward to delivering great science for the benefit of prostate cancer patients! 💪💪💪

A solved physics mystery that @barrallab.bsky.social will love! 😂😂😂 arxiv.org/pdf/2501.00536

Much awaited reunion with @francicapon.bsky.social who recently moved her lab to Vancouver. @ffrancafrat.bsky.social

Best start of 2025: our study on the dual role of CDKN2A in cancer evolution (rdcu.be/d5pty) is out in @naturecancer.bsky.social! Big thanks to Piyali Ganguli who led it, all coauthors and @cancerresearchuk.org archuk.org @crick.ac.uk @qmbci.bsky.social bci.bsky.social for support! Summary below

Great talk @kamatlab.bsky.social and welcome to 🦋! #ICSB2024

Who said computational biology is boring? Traditional Indian dance at #icsb2024

@stemcellsystems.bsky.social showing the effort of her lab in unifying and integrating macrophage gene expression data to produce an atlas of human myeloid compartment. Stemformatics.org #icsb2024 #iitbombay

First day just ended with a glorious reception dinner! Excellent organisation and very lively scientific discussion! #icsb2024 #iitbombay

5/5 @ciccarellilab.bsky.social shows that tumour suppressor genes such as CDKN2A can select against P53 loss. Context of loss of CDKN2A determines cancer evolution and prognosis @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1... #ICSB2024 #SystemsOncology

3/5 @ciccarellilab.bsky.social is interested in the transition between driver mutation in a somatic cell, and probabilistic transition to cancer. genomemedicine.biomedcentral.com/articles/10.... #ICSB2024 #SystemsOncology

@ciccarellilab.bsky.social gives the Plenary for the #ICSB2024 cancer system’s biology session. She introduces the cancer evolution model, with a compendium of cancer driver mutations genomebiology.biomedcentral.com/articles/10.... 1/5

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out! @vivianlilab.bsky.social @kingscollegelondon.bsky.social www.cell.com/cell-reports...

This is my first post written in the blu sky! What a better start than from IIT in Mumbai where i am attending the 23rd International Conference of Systems Biology that just started today! Looking forward for a week of great science!