L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements https://www.biorxiv.org/content/10.1101/2025.09.17.676864v1

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements https://www.biorxiv.org/content/10.1101/2025.09.17.676864v1

Check out our pre-print: We show that L1 insertion intermediates can recombine with one another or with DNA breaks to form genome rearrangements, highlighting the risk of L1 retrotransposition generating substrates for aberrant recombination and genome instability. www.biorxiv.org/content/10.1...

Check out Dr. Mendez-Dorantes' recent preprint for more details on his exciting research! www.biorxiv.org/content/10.1... 42/

Dr. Carlos Mendez-Dorantes @carlosmendezphd.bsky.social from Dr. Kathleen Burns' lab @danafarber.bsky.social is telling us about the LINE-1 retrotransposon and its causal role in genome instability and chromosomal rearrangements in a wide variety of cancers. 41/

It is a cloudy day in Chicago, but the science is shining here inside the Gleacher Center at the University of Chicago at the 2025 JCC Annual Symposium. First up this morning: science talks from our 3rd year JCC Fellows ... buckle up! 1 / a lot

LINE-1 retrotransposons drive genomic instability and immune activation in cancer. In this review, Mendez-Dorantes and Burns discuss their molecular mechanisms, genomic consequences, and diagnostic and therapeutic targetability. Read more here: ➡️ tinyurl.com/genesdev351051

Congrats @carlosmendezphd.bsky.social!!!

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon www.biorxiv.org/content/10.1...

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon https://www.biorxiv.org/content/10.1101/2024.12.14.628481v1

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon https://www.biorxiv.org/content/10.1101/2024.12.14.628481v1

Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS. www.biorxiv.org/content/10.1...