Vaccines don’t just prevent deadly and dangerous diseases like measles, polio and COVID-19. A new study found that people who got the shingles vaccine had a 20% lower risk of developing dementia. buff.ly/5p4z5NS By Anand Kumar and @jalees.bsky.social @uicdom.bsky.social #VaccinesWork 🩺

Grateful for thoughtful News and Views by @cancercachexia.bsky.social pioneers @teresazimmers.bsky.social and Denis Guttridge nature.com/articles/s43... on our paper nature.com/articles/s43... @natcancer.nature.com - highlights need for cross-disciplinary approaches to tackle #cancer #cachexia

📢Article now online at Nature Cancer! 'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia' ✏️By Young-Mee Kim, Jalees Rehman and colleagues 🔗 www.nature.com/articles/s43...

Thrilled to share this publication from our lab on muscle wasting in #Cancer and #vascularbiology, spearheaded by Young-Mee Kim in @natcancer.nature.com nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health @uicancercenter.bsky.social @uofilsystem.bsky.social

Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...

Analysis of multi-condition single-cell data with latent embedding multivariate regression www.nature.com/articles/s41... [email protected] @wkhuber.bsky.social in @naturegenet.bsky.social LEMUR Github: github.com/const-ae/lemur pyLEMUR: github.com/const-ae/pyL...

Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome www.sciencedirect.com/science/arti...

Best practices for differential accessibility analysis in single-cell epigenomics www.nature.com/articles/s41... @naturecomms.bsky.social

TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome www.cell.com/molecular-ce...

A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation www.science.org/doi/10.1126/... Perspective: A neuronal gene that loops the loop www.science.org/doi/10.1126/... in @science.org

Identification of antigen-presenting cell–T cell interactions driving immune responses to food www.science.org/doi/10.1126/... in @science.org

Synthetic organizer cells guide development via spatial and biochemical instructions www.cell.com/cell/fulltex... in @cp-cell.bsky.social "synthetic organizer cells" integrate spatial, temporal, and biochemical information, direct fate trajectories within the morphogenetic landscape

Conventional chemotherapy: millions of cures, unresolved therapeutic index www.nature.com/articles/s41... in @natrevcancer.bsky.social

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice www.science.org/doi/10.1126/... in @science.org

Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses www.science.org/doi/10.1126/... @science.org "coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help"

Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs www.cell.com/molecular-ce...

GenomeDelta: detecting recent transposable element invasions without repeat library genomebiology.biomedcentral.com/articles/10....

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity www.cell.com/cell/fulltex... @cp-cell.bsky.social

Unser Parlament wird aufgelöst, nach den Wahlen gibt es bestimmt Politchaos, weil man sich bei den Umfragewerten kaum eine funktionierende Koalition vorstellen kann. Aber wenigstens hat der Zoll die richtigen Prioritäten: Zoll stoppt geschmuggelte Dubai-Schokolade www.zoll.de/SharedDocs/P...

I hope that @jeremymberg.bsky.social will be assembling these insightful and informative anecdotes into a book or Netflix series: The Life and Opinions of Jeremy Berg, Gentlescientist

Cellular RNA interacts with MAVS to promote antiviral signaling www.science.org/doi/10.1126/... in @science.org

RNA sensing induced by chromosome missegregation augments anti-tumor immunity www.cell.com/molecular-ce...

Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury www.jci.org/articles/vie... in @jclinical-invest.bsky.social with commentary Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs www.jci.org/articles/vie...

Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation www.biorxiv.org/content/10.1...

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon www.biorxiv.org/content/10.1...

Engineered extrachromosomal oncogene amplifications promote tumorigenesis www.nature.com/articles/s41... @natureportfolio.bsky.social Engineered ecDNAs spontaneously accumulate in primary cells derived from mice harbouring Cre-inducible Myc- and Mdm2-containing ecDNAs, promoting tumorigenesis

Nucleosome fibre topology guides transcription factor binding to enhancers www.nature.com/articles/s41... @natureportfolio.bsky.social

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration www.cell.com/cell/fulltex... @cp-cell.bsky.social

Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans www.science.org/doi/10.1126/... @science.org

NIH issues new policy to speed access to agency-funded research results www.nih.gov/about-nih/wh...

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing www.nature.com/articles/s41... "spatially resolved single-cell transcriptomics brain atlas of 4.2 million cells from 20 distinct ages across the adult lifespan and across two rejuvenating interventions"

Giant study finds untrustworthy trials pollute gold-standard medical reviews: Two-year collaboration aims to create tools to help counter the tide of flawed research www.nature.com/articles/d41... @richvn.bsky.social

Harnessing the biology of regulatory T cells to treat disease "highlights results from recent clinical trials aiming to enhance or inhibit Treg cell activity in a variety of diseases, including allergy, transplantation, autoimmunity and cancer" www.nature.com/articles/s41...

Unveiling adipose populations linked to metabolic health in obesity Single-nuclei adipose tissue atlas of metabolically healthy and unhealthy obesity, analysis of adipose plasticity www.cell.com/cell-metabol... @cp-cellmetabolism.bsky.social

Immune mechanisms and shared immune targets in neurodegenerative diseases www.nature.com/articles/s41... @natrevneurol.bsky.social

Light-induced targeting enables proteomics on endogenous condensates www.cell.com/cell/fulltex...

The unbearable slowness of being: Why do we live at 10 bits/s? www.cell.com/neuron/fullt... Why can we only think about one thing at a time? The “outer” brain handles fast high-dimensional sensory and motor signals, whereas the “inner” brain processes the reduced few bits needed to control behavior

Bluetorial: Light and Life: The incredible life of Lubert Stryer I described my involvement with Lubert Stryer and how it led to one of the great opportunities of my life, taking over his textbook. Today, I detail his truly incredible life story.

EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication www.biorxiv.org/content/10.1...

Nutrient-driven histone code determines exhausted CD8+ T cell fates www.science.org/doi/10.1126/... @science.org Citrate-dependent histone acetylation vs acetate-dependent histone acetylation

PDX models for functional precision oncology and discovery science www.nature.com/articles/s41... @natrevcancer.bsky.social

Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer www.cell.com/cell/fulltex... @cellpress.bsky.social

π-HuB: the proteomic navigator of the human body www.nature.com/articles/s41... @natureportfolio.bsky.social "Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale"

Mammalian enhancers and GWASs act proximally and seldom skip active genes www.biorxiv.org/content/10.1...

Intracellular endothelial cell metabolism in vascular function and dysfunction www.cell.com/trends/endoc... in @cp-trendsendomet.bsky.social

Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration www.sciencedirect.com/science/arti...

Protein degraders push into novel target space: Clinic-ready molecular glues and heterobifunctional PROTAC drugs are taking targeted protein degradation into uncharted territory. www.nature.com/articles/d41...

Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes www.cell.com/cell-genomic...

A genome-wide spectrum of tandem repeat expansions in 338,963 humans www.cell.com/cell/fulltex...

Sampling the proteome by emerging single-molecule and mass spectrometry methods www.nature.com/articles/s41... in @naturemethods.bsky.social by @slavov-n.bsky.social