The widely used eGFP sequence produces an unintended protein product https://www.biorxiv.org/content/10.64898/2026.06.02.729456v1

Structural Dynamics of RNA Polymerase II During Nucleotide Addition Cycle https://www.biorxiv.org/content/10.64898/2026.06.04.730248v1

dCas allele sequestration (das-CRISPR): A Versatile New Method to Achieve Monoallelic Gene Editing in Mouse Embryos and in cell culture. https://www.biorxiv.org/content/10.64898/2026.06.03.729891v1

EZH2 inactivation drives MAPK-dependent vulnerability to MEK inhibition in RAS-mutant CMML https://www.biorxiv.org/content/10.64898/2026.06.02.729524v1

Antisense Oligonucleotides Targeting an LDLR Regulatory RNA Increase LDLR Expression and Reduce LDL-cholesterol in Vivo https://www.biorxiv.org/content/10.64898/2026.06.02.729508v1

Modelling antibody structures at the speed of language https://www.biorxiv.org/content/10.64898/2026.06.03.729879v1

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer https://www.biorxiv.org/content/10.64898/2026.06.02.729207v1

PRMT1 arginine methylation of MCM4 restricts ssDNA gap formation during DNA replication https://www.biorxiv.org/content/10.64898/2026.06.03.729374v1

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism https://www.biorxiv.org/content/10.64898/2026.06.01.728939v1

Multi-Omics Characterization of Human Molecular Responses to Spaceflight Across Two Independent Missions https://www.biorxiv.org/content/10.64898/2026.06.01.729304v1

ATG16L2 creates a VAIL-dedicated heterodimer with ATG16L1 https://www.biorxiv.org/content/10.64898/2026.06.01.729256v1

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling https://www.biorxiv.org/content/10.64898/2026.05.30.724257v1

Development and validation of a genome-informed multiplex PCR for specific detection of typhoidal Salmonella serovars https://www.biorxiv.org/content/10.64898/2026.06.01.729223v1

Optimized MALDI-TOF mass spectrometry enables reliable identification of freshwater snails from schistosomiasis-endemic areas in Mauritania https://www.biorxiv.org/content/10.64898/2026.06.01.729200v1

Phosphorylation-dependent regulation of Hsp70 chaperones stimulates client recruitment https://www.biorxiv.org/content/10.64898/2026.06.01.729190v1

Unravelling the role of a disordered chaperone in adaptation to environmental stress https://www.biorxiv.org/content/10.64898/2026.06.01.729257v1

Macrocyclic Peptide Tools for Huntingtin-bound HAP40 https://www.biorxiv.org/content/10.64898/2026.06.02.729325v1

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress https://www.biorxiv.org/content/10.64898/2026.05.29.728910v1

Circular RNA aptamers act as superb sub-stoichiometric chaperones to prevent cytosolic TDP-43 condensation https://www.biorxiv.org/content/10.64898/2026.06.01.729436v1

Better late than never: the impact of hatching time on Heterodera schachtii parasitism https://www.biorxiv.org/content/10.64898/2026.05.29.728720v1

A replication hijacking mechanism for Tn3-family replicative transposition https://www.biorxiv.org/content/10.64898/2026.05.30.728999v1

The Ets family transcription factor EHF suppresses senescence-associated inflammatory responses https://www.biorxiv.org/content/10.64898/2026.05.31.728776v1

SRC Knockdown Impairs Proliferation, Migration, and Invasion While Promoting Apoptosis in HTR8/SVneo Trophoblast Cells via Activation of the PI3K/Akt/Bcl-2 Signaling Pathway https://www.biorxiv.org/content/10.64898/2026.05.28.728375v1

An Integrating Sphere Based Method for Quantifying RNA Encapsulation Efficiency in Lipid Nanoparticles without Lysis https://www.biorxiv.org/content/10.64898/2026.05.29.728751v1

Thousandfold Expansion Microscopy https://www.biorxiv.org/content/10.64898/2026.05.31.729018v1

The defining features of intrinsic transcription terminators https://www.biorxiv.org/content/10.64898/2026.05.29.728758v1

Detection of Pancreatic Cancer Using a Methylation-Specific PCR-Based Multi-Cancer Early Detection Test https://www.biorxiv.org/content/10.64898/2026.05.27.728292v1

Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans https://www.biorxiv.org/content/10.64898/2026.05.27.728313v1

GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation https://www.biorxiv.org/content/10.64898/2026.05.29.728667v1

Expanded Proteome Coverage Powered by Advanced Ion Processing Enables Deep Single-Cell Drug Response Subtyping in Human Stem Cell Derived Cardiomyocytes https://www.biorxiv.org/content/10.64898/2026.05.29.728818v1

Ceramide Synthases Regulate Myristate-Induced Intestinal IRE1α Activation https://www.biorxiv.org/content/10.64898/2026.05.28.728542v1

O-GlcNAc transferase regulates H2O2 production via p38 MAPK https://www.biorxiv.org/content/10.64898/2026.05.27.728188v1

PAIR-link: a ligation-free strategy that joins two RNAs into a single sequence-preserving chimeric cDNA https://www.biorxiv.org/content/10.64898/2026.05.29.728768v1

The b0+ Amino Acid Transporter Defines a Selenium-utilization Enterocyte Program in the Human Intestine https://www.biorxiv.org/content/10.64898/2026.05.27.728150v1

Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation https://www.biorxiv.org/content/10.64898/2026.05.29.728759v1

TgmRHel drives unified RNA processing of coxI mRNA generated from a complex mitochondrial genomic context https://www.biorxiv.org/content/10.64898/2026.05.29.728635v1

Tetramerization and RNA-guided filament assembly control Schlafen-Argonaute antiphage defense https://www.biorxiv.org/content/10.64898/2026.05.29.728809v1

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation https://www.biorxiv.org/content/10.64898/2026.05.27.728122v1

TDP1 drives MRE11-dependent and independent end resection during replication stress by TOP2 poisons https://www.biorxiv.org/content/10.64898/2026.05.29.728668v1

RNA-binding proteins activate transcription through defined molecular grammars https://www.biorxiv.org/content/10.64898/2026.05.29.728737v1

Modular engineering of an extracellular contractile injection system for protein delivery to mammalian and bacterial cells https://www.biorxiv.org/content/10.64898/2026.05.27.728243v1

Microexon alternative splicing and feeding behavior in C. elegans. https://www.biorxiv.org/content/10.64898/2026.05.26.727998v1

Molecular mechanism for the functional divergence between cohesin paralogs during meiosis https://www.biorxiv.org/content/10.64898/2026.05.26.727825v1

Proton-gating of opioid receptors and isoform functionality https://www.biorxiv.org/content/10.64898/2026.05.26.727816v1

c-MYC is Transcribed in a Circadian Manner and Acts as a Clock Disruptor whose Timing Minimizes its Impacts https://www.biorxiv.org/content/10.64898/2026.05.26.727929v1

Leaky scanning translates a conserved ORF in the 3'UTR of RPL36A and regulates the expression of ribosomal protein L36a. https://www.biorxiv.org/content/10.64898/2026.05.26.727855v1

Modulating proton sensing by the adenosine receptor A2 https://www.biorxiv.org/content/10.64898/2026.05.26.727808v1

The CCCH-type zinc-finger PfMD3 promotes translation for malaria parasite transmission https://www.biorxiv.org/content/10.64898/2026.05.27.726058v1

ELOF1 is a core component of the promoter-proximal paused RNA polymerase II complex https://www.biorxiv.org/content/10.64898/2026.05.26.728003v1

DORA: a dose-response autoencoder for interpretable transcriptome-to-viability prediction https://www.biorxiv.org/content/10.64898/2026.05.27.728125v1