An anti-aggregation region of the SGS3 N-terminal IDR is essential for secondary siRNA biogenesis https://www.biorxiv.org/content/10.64898/2026.01.02.697351v1

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops https://www.biorxiv.org/content/10.64898/2026.01.02.697350v1

Parallel ZNF598 and GIGYF2 pathways mediate conserved collision-dependent mRNA decay with distinct endonucleolytic features https://www.biorxiv.org/content/10.64898/2026.01.01.697312v1

Puf3 contributes to changes in mRNA solubility, translation elongation dynamics at rare arginine codons and loss of protein homeostasis in cells lacking Not4 https://www.biorxiv.org/content/10.64898/2025.12.31.695943v1

Evolution tunes functional sub-state interconversion to boost enzyme function https://www.biorxiv.org/content/10.64898/2025.12.31.697001v1

Small extracellular vesicles reflect senescence progression in human bone marrow-derived mesenchymal stem cells during hollow fiber bioreactor culture https://www.biorxiv.org/content/10.64898/2025.12.31.697149v1

Missing steps of mitochondrial translation initiation identified in plants https://www.biorxiv.org/content/10.64898/2025.12.30.697032v1

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function. https://www.biorxiv.org/content/10.64898/2025.12.29.696916v1

Yeast as a platform to dissect poly(ADP-ribose) polymerase function from Magnaporthe oryzae and evaluate PARP inhibitors https://www.biorxiv.org/content/10.64898/2025.12.29.696956v1

Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID https://www.biorxiv.org/content/10.64898/2025.12.28.696747v1

APE1 Coordinates Its Disordered Region and Metal Cofactors to Drive Genome Surveillance https://www.biorxiv.org/content/10.64898/2025.12.28.696760v1

Molecular bases for USP48 cis-activity regulation and hyperactivation by Cushing's disease-associated mutations https://www.biorxiv.org/content/10.64898/2025.12.27.696724v1

Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decay https://www.biorxiv.org/content/10.64898/2025.12.27.695470v1

Endogenous retrotransposon reverse transcriptase supports osteocyte function: implications for antiretroviral therapy-associated bone loss https://www.biorxiv.org/content/10.64898/2025.12.27.696700v1

Transcriptomic and functional characterization indicate sexual dimorphism of discrete circadian neuron subtypes https://www.biorxiv.org/content/10.64898/2025.12.26.696620v1

Improving Cryo-EM Optimization Robustness with an Optimal Transport Loss Function for Noisy Images https://www.biorxiv.org/content/10.64898/2025.12.23.696001v1

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolism https://www.biorxiv.org/content/10.64898/2025.12.26.696635v1

Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction https://www.biorxiv.org/content/10.64898/2025.12.26.696570v1

Single-cell RNA sequencing identifies progenitor dysfunction, inflammation and premature aging in ex vivo airway epithelium-derived from transplant recipients https://www.biorxiv.org/content/10.64898/2025.12.26.696372v1

Structural basis of asymmetric transcription through a composite nucleosome formed by a hexasome and an octasome https://www.biorxiv.org/content/10.64898/2025.12.26.696134v1

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design https://www.biorxiv.org/content/10.64898/2025.12.24.694639v1

Recruitment of Fpt1 to tRNA genes requires TFIIIB and the N-terminal TPR array of TFIIIC subunit {tau}131 https://www.biorxiv.org/content/10.64898/2025.12.24.695929v1

FlashAffinity: Bridging the Accuracy-Speed Gap in Protein-Ligand Binding Affinity Prediction https://www.biorxiv.org/content/10.64898/2025.12.22.695983v1

Deciphering the functional association of novel variants of BMP7 in isolated congenital heart disease by integrating in vitro and in silico approaches https://www.biorxiv.org/content/10.64898/2025.12.23.696272v1

TMC5 promotes lung adenocarcinoma cell proliferation, migration and invasion by regulating epithelial-mesenchymal transition https://www.biorxiv.org/content/10.64898/2025.12.23.696250v1

Intrinsic RNA hairpin-mediated transcription termination at high temperature in Thermus aquaticus https://www.biorxiv.org/content/10.64898/2025.12.25.696493v1

A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in Leishmania mexicana. https://www.biorxiv.org/content/10.64898/2025.12.23.692120v1

Defining the role of RNase E in the mycobacterial degradosome-like network https://www.biorxiv.org/content/10.64898/2025.12.24.696391v1

An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes https://www.biorxiv.org/content/10.64898/2025.12.23.696163v1

Neuropeptide F regulates adult female response to diet, larval locomotion and several larval physiological processes in Lucilia cuprina cuprina https://www.biorxiv.org/content/10.64898/2025.12.22.696103v1

Task-Geometry Alignment: a design principle forparameter-free, accurate genomic search https://www.biorxiv.org/content/10.64898/2025.12.22.696033v1

YfgH is a transmembrane glycine-zipper containing lipoprotein that stabilizes excess cardiolipin and outer membrane proteins during envelope stress https://www.biorxiv.org/content/10.64898/2025.12.22.696046v1

HAMMER: Hairpin-based APOBEC3A-mediated mRNA editing reporter https://www.biorxiv.org/content/10.64898/2025.12.22.695965v1

Oncogene c-Myc Regulates Upper Respiratory Epithelial Repair for Host Immunity During Acute Influenza Infection https://www.biorxiv.org/content/10.64898/2025.12.22.696065v1

Direct detection of CRISPR mutations and transcriptional responses at single cell resolution in vivo https://www.biorxiv.org/content/10.64898/2025.12.23.696319v1

Structural reorganization underlying stress-induced cytoplasmicsolidification in yeast https://www.biorxiv.org/content/10.64898/2025.12.22.696049v1

Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E https://www.biorxiv.org/content/10.64898/2025.12.23.696204v1

An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity https://www.biorxiv.org/content/10.64898/2025.12.21.695840v1

A new class of proteinaceous biomaterial with unprecedented properties in unicellular eukaryotes https://www.biorxiv.org/content/10.64898/2025.12.22.695910v1

A panel of CYP6Z genes drives broad-spectrum cross-resistance to public health insecticides in the major malaria vector An. gambiae s.s. https://www.biorxiv.org/content/10.64898/2025.12.22.695880v1

Transcriptome-wide mapping reveals an RNA-dependent mechanism of platinum cancer drugs. https://www.biorxiv.org/content/10.64898/2025.12.20.694502v1

Recombinant Laccase Production Causes Alterations of the S. cerevisiae Proteome that are Dependent on the Strain Origins https://www.biorxiv.org/content/10.64898/2025.12.22.696128v1

The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers https://www.biorxiv.org/content/10.64898/2025.12.22.695993v1

Copy Number Variation-Based Molecular Sexing of Ixodes scapularis and Rhipicephalus microplus Immature Stages Using qPCR and ddPCR Approaches https://www.biorxiv.org/content/10.64898/2025.12.19.695610v1

Epitranscriptomic landscape of vascular smooth muscle cell phenotypic transitions highlights uridine RNA modifications associated with post-transcriptional regulation https://www.biorxiv.org/content/10.64898/2025.12.19.694735v1

The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in Shigella flexneri https://www.biorxiv.org/content/10.64898/2025.12.19.695565v1

Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and miRNA Suppression https://www.biorxiv.org/content/10.64898/2025.12.20.695716v1

From storms to warming seas: a long-term metabarcoding survey in port communities unveils high genetic diversity and ecological resilience of non-indigenous species https://www.biorxiv.org/content/10.64898/2025.12.20.695700v1

Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins https://www.biorxiv.org/content/10.64898/2025.12.19.695459v1

tBid mediated genetic ablation of connective tissue cells reveal their key regulatory function during limb regeneration in axolotls https://www.biorxiv.org/content/10.64898/2025.12.19.695438v1