RNA degradation by ribonuclease T2 is required for phosphate homeostasis in S. cerevisiae https://www.biorxiv.org/content/10.64898/2026.07.20.739639v1

DNA Polymerase beta Accelerates Cellular DNA Base Excision Repair by Suppressing Excessive PARP1 Engagement https://www.biorxiv.org/content/10.64898/2026.07.20.739154v1

Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivation https://www.biorxiv.org/content/10.64898/2026.07.20.737372v1

Fat body CLOCK restrains innate immunity and maintains survival under dietary stress in Drosophila https://www.biorxiv.org/content/10.64898/2026.07.20.739608v1

CAFE: A Co-folding Approach for Fragment Exploration of Allosteric and Cryptic Binding Sites https://www.biorxiv.org/content/10.64898/2026.07.19.739466v1

Unmasking Early Renal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen https://www.biorxiv.org/content/10.64898/2026.07.19.739445v1

Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis. https://www.biorxiv.org/content/10.64898/2026.07.20.739521v1

Highly Pathogenic Avian Influenza H5N5 in a Polar Bear and Atlantic Walrus, Svalbard, 2026, with Widespread Seroconversion in Polar Bears https://www.biorxiv.org/content/10.64898/2026.07.20.739480v1

JAK and TYK2 inhibitors differentially modulate interferon/TNF-driven inflammation, stemness and proliferation in the colonic epithelium of ulcerative colitis https://www.biorxiv.org/content/10.64898/2026.07.20.739113v1

Characterization of Chromatin-Associated Circular RNAs (cacRNAs) https://www.biorxiv.org/content/10.64898/2026.07.20.739476v1

Cross-talk among miRNAs, lncRNAs, and DNA methylation in three coral species reveal conserved epigenetic regulatory architecture https://www.biorxiv.org/content/10.64898/2026.07.19.739451v1

NUMonomer enables accurate and scalable nucleic acid structure prediction from primary sequence alone https://www.biorxiv.org/content/10.64898/2026.07.20.739453v1

Toxoplasma TgATG2 works with TgATG9 and TgProp1 to drive autophagic flux for parasite extracellular survival and persistence. https://www.biorxiv.org/content/10.64898/2026.07.16.739079v1

FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer https://www.biorxiv.org/content/10.64898/2026.07.18.739353v1

A targeted mass-spectrometry plasma proteome for simultaneous multi-disease screening https://www.biorxiv.org/content/10.64898/2026.07.18.739311v1

Age-dependent Structural Reorganization of the Human Plasma Proteome https://www.biorxiv.org/content/10.64898/2026.07.19.739388v1

ORC binding to Heterochromatin Protein 1 through intrinsically disordered regions is required for heterochromatin structure and function https://www.biorxiv.org/content/10.64898/2026.07.17.738698v1

Analytical Validation of Automated DNA Isolation from Meat Matrices for High-Quality PCR-Based Food Authentication https://www.biorxiv.org/content/10.64898/2026.07.17.739293v1

Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells https://www.biorxiv.org/content/10.64898/2026.07.17.739209v1

Stressor identity shapes plasma proteomic and metabolic responses in humans https://www.biorxiv.org/content/10.64898/2026.07.17.739102v1

Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum https://www.biorxiv.org/content/10.64898/2026.07.16.738923v1

Human 28S rRNA analysed by state-of-the-art oligonucleotide mass spectrometry: benchmarking current capabilities and a call to action for MS-Seq https://www.biorxiv.org/content/10.64898/2026.07.17.739151v1

Intranucleolar Invasion of Cajal Body Remnants Suppresses Ribosomal Biogenesis in cis and Telomerase Functions in trans https://www.biorxiv.org/content/10.64898/2026.07.16.738943v1

Hybrid Tetramers of Wild-Type and Amyloidogenic H88R Transthyretin Challenge the Monomer Paradigm https://www.biorxiv.org/content/10.64898/2026.07.13.738148v1

Structural tuning of native type V fimbriae shapes mechanical specialization in Porphyromonas gingivalis https://www.biorxiv.org/content/10.64898/2026.07.16.738973v1

MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation https://www.biorxiv.org/content/10.64898/2026.07.16.738964v1

Optogenetic decoupling of ODC inhibition and degradation reveals a requirement of polyamine oscillation for cell cycle progression https://www.biorxiv.org/content/10.64898/2026.07.16.739060v1

The Disease Gene THAP12 is a Transcriptional Regulator of Mitochondrial ETC Complex I https://www.biorxiv.org/content/10.64898/2026.07.16.738975v1

A long-hidden prevalent PCR artifact and its application in DNA library screening https://www.biorxiv.org/content/10.64898/2026.07.17.737729v1

DNA catenation is essential for Sister Chromatid Cohesion https://www.biorxiv.org/content/10.64898/2026.07.16.738924v1

Overlapping upstream ORFs repress translation and expand proteome diversity in Arabidopsis https://www.biorxiv.org/content/10.64898/2026.07.14.738309v1

Systematic Development of a Compact Genome-Editing Tool Leveraging the TAM-Independent DNA Nuclease TasR in Bacillus subtilis https://www.biorxiv.org/content/10.64898/2026.07.15.738680v1

OddCAPS: a simple, low-cost, universal technique for detecting single nucleotide variants https://www.biorxiv.org/content/10.64898/2026.07.16.738826v1

A superfolding sfPepper enables superresolution and single-molecule RNA imaging in live cells https://www.biorxiv.org/content/10.64898/2026.07.15.738587v1

A eutherian-specific metaviral gene, RTL6, coordinates microglial inflammatory responsiveness and state regulation https://www.biorxiv.org/content/10.64898/2026.07.15.738833v1

The novel HP1a interactor Clump/CG30403 safeguards transposon silencing and reproductive resilience in the Drosophila ovary https://www.biorxiv.org/content/10.64898/2026.07.15.738798v1

A CRISPR/Cas9-induced blunt-end telomere system in S. pombe reveals RNase H2-dependent RNA primer removal at the terminal Okazaki fragment of lagging telomeres https://www.biorxiv.org/content/10.64898/2026.07.15.738813v1

Barcode-integrated reverse transcription for accurate, complete, and low-input RNA sequencing https://www.biorxiv.org/content/10.64898/2026.07.15.738812v1

Methodological assessment of PDMS passive sampling for skin VOC collection across body sites https://www.biorxiv.org/content/10.64898/2026.07.15.738701v1

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations https://www.biorxiv.org/content/10.64898/2026.07.15.738714v1

Multidimensional atlas of RNA-regulated proteins revealed by RNA-dependent thermal proteome profiling https://www.biorxiv.org/content/10.64898/2026.07.15.738841v1

RiboCollSensor: a sensitive real-time detector of ribosome collisions in mammalian cells based on split-NanoLuc complementation https://www.biorxiv.org/content/10.64898/2026.07.15.738639v1

Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer https://www.biorxiv.org/content/10.64898/2026.07.15.738711v1

Insights into mechanisms of ATM activation via constitutively active mutants https://www.biorxiv.org/content/10.64898/2026.07.15.738190v1

OTTR-CLASH: improved biochemical and bioinformatic identification of Argonaute 2-mediated microRNA-target RNA interactions https://www.biorxiv.org/content/10.64898/2026.07.14.738487v1

Multiparameter optimization extends the lifetime of cell-free protein synthesis in a high-throughput format https://www.biorxiv.org/content/10.64898/2026.07.15.738603v1

Promoter-associated RNA polymerase III shapes RNA polymerase II-dependent inflammatory gene expression during viral infection https://www.biorxiv.org/content/10.64898/2026.07.13.738346v1

Bovine AAV - a promising vector for pulmonary gene therapy https://www.biorxiv.org/content/10.64898/2026.07.14.738418v1

ZATT/ZNF451 promotes release of stalled TOP2 cleavage complexes https://www.biorxiv.org/content/10.64898/2026.07.14.738426v1

SF3B3 / SF3B5 form a metazoan specific transcription module of the U2 snRNP that coordinates Pol II elongation in a splicing independent manner https://www.biorxiv.org/content/10.64898/2026.07.14.737342v1