Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape https://www.biorxiv.org/content/10.64898/2026.01.08.698330v1

The cap-independent translational regulation of NbRabGAP1 in Nicotiana benthamiana during BaMV infection https://www.biorxiv.org/content/10.64898/2026.01.07.698292v1

Kinetochore Homeostasis is Maintained by Coordinated Chromatin Stabilization and Soluble Buffering https://www.biorxiv.org/content/10.64898/2026.01.07.698278v1

[225Ac]Ac-FAPI-04 Promotes Anti-tumor Immunity via IL-27 Activation and Tnfaip3 Inhibition https://www.biorxiv.org/content/10.64898/2026.01.07.698054v1

Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa https://www.biorxiv.org/content/10.64898/2026.01.07.697087v1

Fishing with Two Lines: A Hybrid Approach to Spatial Transcriptomic Discovery https://www.biorxiv.org/content/10.64898/2026.01.07.698201v1

Hierarchical bounds on RNA chromatin statistical dependence across cellular states in paired single-cell multiome data https://www.biorxiv.org/content/10.64898/2026.01.07.698181v1

Longitudinal Plasma Proteome Changes Before and After Catheter Ablation in Atrial Fibrillation https://www.biorxiv.org/content/10.64898/2026.01.07.698107v1

Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on select O-glycoproteins https://www.biorxiv.org/content/10.64898/2026.01.07.698156v1

Telomere length can be estimated from fish scales https://www.biorxiv.org/content/10.64898/2026.01.07.698083v1

A PIWI protein-dependent DNA N6-adenine methylation pathway in Oxytricha protects genomic sequences from deletion https://www.biorxiv.org/content/10.64898/2026.01.06.698049v1

SLBP-independent control of maternal histone mRNA https://www.biorxiv.org/content/10.64898/2026.01.06.697898v1

Intermittent AP-1 activation in muscles contributes to exercise-induced health benefits https://www.biorxiv.org/content/10.64898/2026.01.05.696542v1

NORAD orchestrates KLC1-mediated SFPQ transport via liquid-liquid phase separation https://www.biorxiv.org/content/10.64898/2026.01.06.697853v1

CNOT10 is involved in TTP-mediated AU-rich element containing mRNA metabolism, independent of mRNA decay regulation https://www.biorxiv.org/content/10.64898/2026.01.05.697706v1

A targeted mutational strategy aiding generating antisense RNA to knockdown the Ehrlichia chaffeensis p28-outer membrane protein 19 expression https://www.biorxiv.org/content/10.64898/2026.01.05.697664v1

A Genome-Wide Genetic Screen Identifies a Novel kDNA Replication Protein in Trypanosomes https://www.biorxiv.org/content/10.64898/2026.01.05.697628v1

Diverse bacterial pattern recognition receptors sense the conserved phage proteome https://www.biorxiv.org/content/10.64898/2026.01.04.697583v1

The role of relA-mediated stringent response on the nutritional, environmental, antimicrobial resistance and biofilm formation in Klebsiella pneumoniae and its effect on Drosophila melanogaster survival https://www.biorxiv.org/content/10.64898/2026.01.04.697604v1

Targeted 3'-end RNA sequencing uncovers cryptic polyadenylation in Huntington's disease linked to somatic instability and CAG repeat purity https://www.biorxiv.org/content/10.64898/2026.01.03.697463v1

Preconceptional immunomodulation partially corrects pregnancy associated abnormalities induced by endometriosis in a mice model, with ... https://www.biorxiv.org/content/10.64898/2026.01.02.695166v1

An anti-aggregation region of the SGS3 N-terminal IDR is essential for secondary siRNA biogenesis https://www.biorxiv.org/content/10.64898/2026.01.02.697351v1

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops https://www.biorxiv.org/content/10.64898/2026.01.02.697350v1

Parallel ZNF598 and GIGYF2 pathways mediate conserved collision-dependent mRNA decay with distinct endonucleolytic features https://www.biorxiv.org/content/10.64898/2026.01.01.697312v1

Puf3 contributes to changes in mRNA solubility, translation elongation dynamics at rare arginine codons and loss of protein homeostasis in cells lacking Not4 https://www.biorxiv.org/content/10.64898/2025.12.31.695943v1

Evolution tunes functional sub-state interconversion to boost enzyme function https://www.biorxiv.org/content/10.64898/2025.12.31.697001v1

Small extracellular vesicles reflect senescence progression in human bone marrow-derived mesenchymal stem cells during hollow fiber bioreactor culture https://www.biorxiv.org/content/10.64898/2025.12.31.697149v1

Missing steps of mitochondrial translation initiation identified in plants https://www.biorxiv.org/content/10.64898/2025.12.30.697032v1

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function. https://www.biorxiv.org/content/10.64898/2025.12.29.696916v1

Yeast as a platform to dissect poly(ADP-ribose) polymerase function from Magnaporthe oryzae and evaluate PARP inhibitors https://www.biorxiv.org/content/10.64898/2025.12.29.696956v1

Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID https://www.biorxiv.org/content/10.64898/2025.12.28.696747v1

APE1 Coordinates Its Disordered Region and Metal Cofactors to Drive Genome Surveillance https://www.biorxiv.org/content/10.64898/2025.12.28.696760v1

Molecular bases for USP48 cis-activity regulation and hyperactivation by Cushing's disease-associated mutations https://www.biorxiv.org/content/10.64898/2025.12.27.696724v1

Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decay https://www.biorxiv.org/content/10.64898/2025.12.27.695470v1

Endogenous retrotransposon reverse transcriptase supports osteocyte function: implications for antiretroviral therapy-associated bone loss https://www.biorxiv.org/content/10.64898/2025.12.27.696700v1

Transcriptomic and functional characterization indicate sexual dimorphism of discrete circadian neuron subtypes https://www.biorxiv.org/content/10.64898/2025.12.26.696620v1

Improving Cryo-EM Optimization Robustness with an Optimal Transport Loss Function for Noisy Images https://www.biorxiv.org/content/10.64898/2025.12.23.696001v1

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolism https://www.biorxiv.org/content/10.64898/2025.12.26.696635v1

Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction https://www.biorxiv.org/content/10.64898/2025.12.26.696570v1

Single-cell RNA sequencing identifies progenitor dysfunction, inflammation and premature aging in ex vivo airway epithelium-derived from transplant recipients https://www.biorxiv.org/content/10.64898/2025.12.26.696372v1

Structural basis of asymmetric transcription through a composite nucleosome formed by a hexasome and an octasome https://www.biorxiv.org/content/10.64898/2025.12.26.696134v1

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design https://www.biorxiv.org/content/10.64898/2025.12.24.694639v1

Recruitment of Fpt1 to tRNA genes requires TFIIIB and the N-terminal TPR array of TFIIIC subunit {tau}131 https://www.biorxiv.org/content/10.64898/2025.12.24.695929v1

FlashAffinity: Bridging the Accuracy-Speed Gap in Protein-Ligand Binding Affinity Prediction https://www.biorxiv.org/content/10.64898/2025.12.22.695983v1

Deciphering the functional association of novel variants of BMP7 in isolated congenital heart disease by integrating in vitro and in silico approaches https://www.biorxiv.org/content/10.64898/2025.12.23.696272v1

TMC5 promotes lung adenocarcinoma cell proliferation, migration and invasion by regulating epithelial-mesenchymal transition https://www.biorxiv.org/content/10.64898/2025.12.23.696250v1

Intrinsic RNA hairpin-mediated transcription termination at high temperature in Thermus aquaticus https://www.biorxiv.org/content/10.64898/2025.12.25.696493v1

A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in Leishmania mexicana. https://www.biorxiv.org/content/10.64898/2025.12.23.692120v1

Defining the role of RNase E in the mycobacterial degradosome-like network https://www.biorxiv.org/content/10.64898/2025.12.24.696391v1

An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes https://www.biorxiv.org/content/10.64898/2025.12.23.696163v1