Spatial organization of myofibroblastic and complement-secreting CAFs in neuroendocrine tumors https://www.biorxiv.org/content/10.64898/2026.02.26.708188v1

Reference-free single-vesicle profiling of small extracellular vesicles from liquid biopsies with the PICO assay https://www.biorxiv.org/content/10.64898/2026.02.27.707718v1

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology https://www.biorxiv.org/content/10.64898/2026.02.27.708452v1

Modeling Sex Differences and Neurodegeneration in Repetitive Traumatic Brain Injury Using Drosophila https://www.biorxiv.org/content/10.64898/2026.02.27.708626v1

Autophagy induction requires the suppression of potassium influx mediated by phosphatases https://www.biorxiv.org/content/10.64898/2026.02.27.707896v1

A full-length single nuclei transcriptomic atlas of human skeletal muscle insulin resistance https://www.biorxiv.org/content/10.64898/2026.02.26.708250v1

RNA-binding is the essential biological function of the Drosophila protein Brat https://www.biorxiv.org/content/10.64898/2026.02.27.708583v1

Circular Smad1-Encoded Polypeptide Regulates Myogenesis https://www.biorxiv.org/content/10.64898/2026.02.26.708385v1

Opposing regulatory logics converge on ABA receptors to govern the trade-off between growth and drought acclimation https://www.biorxiv.org/content/10.64898/2026.02.26.708209v1

lncRNA-ISM1 Promotes Hepatocellular Carcinoma Progression through RBM10-Mediated Alternative Splicing of ISM1 and Akt-S6-Dependent Glucose Metabolic Reprogramming https://www.biorxiv.org/content/10.64898/2026.02.27.708505v1

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy https://www.biorxiv.org/content/10.64898/2026.02.26.707014v1

Fully Phased Telomere-to-Telomere Assemblies for Thoroughbred Horse and Donkey Haplotypes derived from a Mule Illuminate the Peculiar Evolution of Equid Centromeres https://www.biorxiv.org/content/10.64898/2026.02.26.707634v1

Targeted DNA methylation editing in vivo https://www.biorxiv.org/content/10.64898/2026.02.26.708277v1

Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells https://www.biorxiv.org/content/10.64898/2026.02.26.708234v1

Summarizing RNA Structural Ensembles via Maximum Agreement Secondary Structures https://www.biorxiv.org/content/10.64898/2026.02.25.708069v1

RNA-DNA triplex-forming miRNAs define an evolutionarily recent chromatin regulatory mechanism https://www.biorxiv.org/content/10.64898/2026.02.25.707792v1

Dynamic engagement of dual-role regulators by the Sin3 complex https://www.biorxiv.org/content/10.64898/2026.02.26.708192v1

Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition https://www.biorxiv.org/content/10.64898/2026.02.25.708058v1

Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling https://www.biorxiv.org/content/10.64898/2026.02.24.707845v1

Molecular Diversity and Recombination Patterns of the ORF7 (Nucleocapsid) Gene in Betaarterivirus americense Variants Circulating from Lima, Peru https://www.biorxiv.org/content/10.64898/2026.02.24.707833v1

Unified function of FACT in mammalian chromatin replication and transcription, dissolving and restoring nucleosomes to counteract genome aggregation https://www.biorxiv.org/content/10.64898/2026.02.25.707725v1

Co-option of a mouse-specific retrotransposon rewires Ash2l isoform usage to prime developmental promoters https://www.biorxiv.org/content/10.64898/2026.02.25.707914v1

HIF-1α coordinates adrenal steroidogenesis through direct transcriptional control and regulation of miRNA biogenesis https://www.biorxiv.org/content/10.64898/2026.02.24.707817v1

Evidence of Anopheles stephensi involvement in the transmission of Plasmodium vivax in Djibouti, 2024 https://www.biorxiv.org/content/10.64898/2026.02.25.707780v1

Optimized tRNA Structure-seq reveals robust tRNA secondary structures in S. cerevisiae under mild stress conditions https://www.biorxiv.org/content/10.64898/2026.02.24.707850v1

LEMONmethyl-seq: Targeted long-read DNA methylation profiling reveals dynamics of CRISPR epigenome editing and endogenous DNA methylation patterns https://www.biorxiv.org/content/10.64898/2026.02.24.707761v1

Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages https://www.biorxiv.org/content/10.64898/2026.02.24.707668v1

Dosage compensation defects due to roX RNA deletion are rescued by recalibration of X/autosome stoichiometry https://www.biorxiv.org/content/10.64898/2026.02.24.707606v1

An Alport variant illuminates the bioactivity of the collagen IV α565- α121 scaffold in Bowman's capsule. https://www.biorxiv.org/content/10.64898/2026.02.23.707599v1

Annexin A2 Regulates Surfactant Dysfunction During Injurious Ventilation. https://www.biorxiv.org/content/10.64898/2026.02.24.707549v1

Molecular characterization of chikungunya viruses associated with outbreaks in Kenya from 2017 to 2020 https://www.biorxiv.org/content/10.64898/2026.02.23.707436v1

Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon https://www.biorxiv.org/content/10.64898/2026.02.23.707533v1

Testing vivo-morpholino mediated gene knockdown in threespine stickleback https://www.biorxiv.org/content/10.64898/2026.02.24.707669v1

Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in Tissues https://www.biorxiv.org/content/10.64898/2026.02.23.707224v1

Proteomic Signatures of Mitochondrial Dysfunction Associated with Atrial Fibrillation in Goats https://www.biorxiv.org/content/10.64898/2026.02.23.707419v1

Developmentally Regulated GTP-binding Protein Drg1 defines a translational decision point that protects mitochondrial integrity https://www.biorxiv.org/content/10.64898/2026.02.23.707305v1

Oncogenic chromodomain mutations allosterically impair TIP60 acetyltransfearse function preventing activation of DNA repair genes under genotoxic stress https://www.biorxiv.org/content/10.64898/2026.02.23.707364v1

Small molecule ensembles reshape amyloid aggregation landscapes https://www.biorxiv.org/content/10.64898/2026.02.22.706957v1

Evaluating primer and probe mismatch tolerance in an Influenza A matrix gene RT qPCR using contemporary human and zoonotic strains https://www.biorxiv.org/content/10.64898/2026.02.23.707407v1

HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2 https://www.biorxiv.org/content/10.64898/2026.02.22.707301v1

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice. https://www.biorxiv.org/content/10.64898/2026.02.21.707196v1

HDAC5-encoded Microprotein NISM Mediates Nucleolar Formation and Ribosomal RNA Synthesis https://www.biorxiv.org/content/10.64898/2026.02.21.707204v1

SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells https://www.biorxiv.org/content/10.64898/2026.02.21.707202v1

rRNA Expansion Segments Mediate Ribosome Dimerization as a Conserved Stress Response https://www.biorxiv.org/content/10.64898/2026.02.21.707218v1

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and FANCM synthetic lethality https://www.biorxiv.org/content/10.64898/2026.02.20.706968v1

The Tor pathway, ribosome concentration, and wobble decoding mediate inhibitory effects of the Leu-Pro CUC-CCG codon pair in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.64898/2026.02.20.707122v1

Collagen IV of basement membrane: V. Bromide-mediated sulfilimine bonds interlock the quaternary structure of NC1-hexamer of scaffolds enabling metazoan evolution. https://www.biorxiv.org/content/10.64898/2026.02.20.707065v1

The long non-coding RNA ACHLYS modulates biomolecular condensates to regulate alternative splicing in root development https://www.biorxiv.org/content/10.64898/2026.02.20.706954v1

Histone H2BK120 ubiquitination modulates PRC1 activity and H2AK119ub deposition on nucleosomes https://www.biorxiv.org/content/10.64898/2026.02.20.706939v1

Atomic structure and plasticity of the MthK-CTX complex investigated by cryo-EM, NMR, and MD simulations https://www.biorxiv.org/content/10.64898/2026.02.20.706983v1