Dynamics of TFIIH and Spt5 during the transition from transcription initiation to elongation https://www.biorxiv.org/content/10.1101/2025.11.17.686592v1

A scalable screening platform for discovering predominant miRNA target genes and druggable siRNA sequences https://www.biorxiv.org/content/10.1101/2025.11.17.688664v1

Validation of Extracellular Vesicles in FACTORFIVEs EXOFECTA LyoBeads https://www.biorxiv.org/content/10.1101/2025.11.17.688893v1

Differential contribution of the RNA recognition motifs to SRSF1 protein interaction network https://www.biorxiv.org/content/10.1101/2025.11.17.688470v1

Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen https://www.biorxiv.org/content/10.1101/2025.11.16.688752v1

Condensin chromatin association is regulated by SMC head and hinge engagement and phosphorylation https://www.biorxiv.org/content/10.1101/2025.11.17.688780v1

MPKaDB: A pKa Database for Exploring pH Dependence in Membrane Proteins https://www.biorxiv.org/content/10.1101/2025.11.14.688495v1

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome folding https://www.biorxiv.org/content/10.1101/2025.11.17.688764v1

Global Mapping of circRNA-Target RNA Interactions Reveals P-Body-Mediated Translational Repression https://www.biorxiv.org/content/10.1101/2025.11.16.688748v1

abcFISH enables multiplexed, single-molecule visualization of circular RNA spatial heterogeneity https://www.biorxiv.org/content/10.1101/2025.11.16.688740v1

Reliable repurposing of antibody interactome inside the cell https://www.biorxiv.org/content/10.1101/2025.11.16.688718v1

Nonsense mutations can also increase mRNA levels https://www.biorxiv.org/content/10.1101/2025.11.16.688500v1

Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network https://www.biorxiv.org/content/10.1101/2025.11.14.688535v1

ENGINEERING AND PRECLINICAL EVALUATION OF DRIED FOOD-FORMULATED YEAST-SECRETED ANTIBODIES AS PERI-EXPOSURE PROPHYLAXIS AGAINST CLOSTRIDIOIDES DIFFICILE DISEASE. https://www.biorxiv.org/content/10.1101/2025.11.14.688569v1

The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin https://www.biorxiv.org/content/10.1101/2025.11.14.688564v1

Yuanyang allele pairs enable engineered obligate co-inheritance for population replacement and suppression https://www.biorxiv.org/content/10.1101/2025.11.14.688408v1

Disruption of the FGFR1-FGF23-Phosphate Axis and Targeted Therapy in a Murine Model of Osteoglophonic Dysplasia https://www.biorxiv.org/content/10.1101/2025.11.14.680268v1

Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells https://www.biorxiv.org/content/10.1101/2025.11.14.688451v1

Proteolytic activation of diverse antiviral defense modules in prokaryotes https://www.biorxiv.org/content/10.1101/2025.11.14.688446v1

Modulating MyoD1 dosage activates alternate cell fate beyond myogenic differentiation https://www.biorxiv.org/content/10.1101/2025.11.13.688391v1

Fiber Type and Stimulus Determine Progression of Skeletal Muscle Atrophy https://www.biorxiv.org/content/10.1101/2025.11.13.687882v1

Thermal optimized PCR coupled to CRISPR-Cas12a for rapid detection of blaOXA-1 resistance gene https://www.biorxiv.org/content/10.1101/2025.11.13.688324v1

A cytochrome P450 G subfamily member, CYP4G35, is highly expressed in antennae and modulates olfactory response in Aedes aegypti mosquitoes. https://www.biorxiv.org/content/10.1101/2025.11.13.688110v1

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1 https://www.biorxiv.org/content/10.1101/2025.11.13.688213v1

A biological PROTAC for α-synuclein. https://www.biorxiv.org/content/10.1101/2025.11.13.687972v1

TRIM24 preserves cardiomyocyte immune quiescence by repressing interferon/STAT signaling https://www.biorxiv.org/content/10.1101/2025.11.13.688187v1

Expression of four mitochondrial tRNAs from only two loci https://www.biorxiv.org/content/10.1101/2025.11.12.688142v1

Mutant p53 binds RNA to drive mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2025.11.12.688127v1

Cytoplasmic roles of HSATIII RNAs in RNA granule assembly and production of actin cytoskeleton-associated repeat-containing proteins https://www.biorxiv.org/content/10.1101/2025.11.12.688122v1

Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage https://www.biorxiv.org/content/10.1101/2025.11.12.685177v1

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker) https://www.biorxiv.org/content/10.1101/2025.11.12.688114v1

Structural basis for co-translational assembly of homo-oligomeric proteins https://www.biorxiv.org/content/10.1101/2025.11.12.687954v1

Structural basis of lipid-mediated gating in a two-pore domain potassium channel https://www.biorxiv.org/content/10.1101/2025.11.12.688043v1

Export-biased, 3'UTR-preserving TDP-43 model links nuclear loss to cytoplasmic aggregation in ALS/FTLD https://www.biorxiv.org/content/10.1101/2025.11.12.687969v1

Phase Behavior of TDP-43 and hnRNP H1: From Soluble and Aggregated States to Liquid-Like Droplets https://www.biorxiv.org/content/10.1101/2025.11.12.687994v1

Assessing the molecular and phenotypic contribution of a horizontally acquired region to yeast adaptation https://www.biorxiv.org/content/10.1101/2025.11.11.687820v1

Robust design and validation of LAMP assays for in-field detection of three major bacterial vascular diseases of banana https://www.biorxiv.org/content/10.1101/2025.11.10.687727v1

Widespread DNA off-targeting confounds studies of RNA chromatin occupancy https://www.biorxiv.org/content/10.1101/2025.11.11.687850v1

Enabling regiospecific di-halogenation in one-pot reactions using an engineered single-component flavin-dependent tryptophan halogenase https://www.biorxiv.org/content/10.1101/2025.11.10.687318v1

Phylo-MIP: Phylogeny-based Molecular Identification Pipeline for DNA metabarcoding, and assessment of insect communities in subalpine river ecosystems https://www.biorxiv.org/content/10.1101/2025.11.10.687572v1

USP-ddG: A Unified Structural Paradigm with Data Efficacy and Mixture-of-Experts for Predicting Mutational Effects on Protein-Protein Interactions https://www.biorxiv.org/content/10.1101/2025.11.09.687124v1

Plasmodium falciparum Myosin F with a Rab-like tail domain localises to perinuclear membranes and associates with trafficking proteins https://www.biorxiv.org/content/10.1101/2025.11.10.687607v1

Integrated Antibody and DIA Based Plasma Proteomics Uncover Temporal Host Responses to SARS CoV 2 Infection https://www.biorxiv.org/content/10.1101/2025.11.06.687090v1

Co-occurrence of Antibiotic Residues and Antimicrobial Resistance Genes in Animal Manure and Agricultural Soils from Machakos, Kiambu, and Kajiado Counties, Kenya https://www.biorxiv.org/content/10.1101/2025.11.09.687469v1

Cryo-EM structures of the BAM-P2-visible SurA complex reveal dynamic and cooperative interactions in outer membrane protein assembly https://www.biorxiv.org/content/10.1101/2025.11.10.687524v1

The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse models https://www.biorxiv.org/content/10.1101/2025.11.10.687599v1

Development and pilot application of a point-of-need molecular xenomonitoring protocol for tsetse (Glossina sp.) in a low-resource setting https://www.biorxiv.org/content/10.1101/2025.11.10.685795v1

Engineered bacterial M1GS ribozyme efficiently cleaves the most abundant ribosomal RNA in a human cancer cell line https://www.biorxiv.org/content/10.1101/2025.11.07.687305v1

PPAR-delta rather than PPAR-gamma is likely to be the key modulator of central carbon metabolism in human adipocytes https://www.biorxiv.org/content/10.1101/2025.11.08.687092v1

Single-Molecule Imaging Reveals Transcription-Driven Supercoiling in Unconstrained DNA https://www.biorxiv.org/content/10.1101/2025.11.08.687369v1