Structures of muscle-type nicotinic acetylcholine receptor with α-conotoxins reveal determinants of receptor-subtype specificity https://www.biorxiv.org/content/10.64898/2026.01.15.699711v1

Cysteine Glutathionylation as a Global Dynamic Regulator of Protein Active Site Accessibility and Protein Complex Formation https://www.biorxiv.org/content/10.64898/2026.01.15.699703v1

RadarOmics: Intuitive visualisation of multidimensional omics data in ecological, evolutionary, and developmental studies https://www.biorxiv.org/content/10.64898/2026.01.14.699593v1

Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usage https://www.biorxiv.org/content/10.64898/2026.01.14.699446v1

Region-specific generation and retention of acetylated cohesin shape the genome-wide pattern of sister chromatid cohesion https://www.biorxiv.org/content/10.64898/2026.01.14.699591v1

Viscoelastic flow-integrated Raman spectroscopy platform https://www.biorxiv.org/content/10.64898/2026.01.13.699233v1

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes https://www.biorxiv.org/content/10.64898/2026.01.14.699602v1

Enhancing Lipid Detection and Spatial Accuracy in Carotid Plaques Using Mass Spectrometry Imaging Techniques https://www.biorxiv.org/content/10.64898/2026.01.14.699204v1

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF https://www.biorxiv.org/content/10.64898/2026.01.14.699428v1

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis https://www.biorxiv.org/content/10.64898/2026.01.14.698769v1

Origin-1: a generative AI platform for de novo antibody design against novel epitopes https://www.biorxiv.org/content/10.64898/2026.01.14.699389v1

CCAN forms the spherical shell-like structure in interphase kinetochores https://www.biorxiv.org/content/10.64898/2026.01.14.699427v1

Vitamin B12 Improves Skeletal Muscle Mitochondrial Biology in Aged Mice https://www.biorxiv.org/content/10.64898/2026.01.13.699119v1

Engineered Allosteric Control Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors https://www.biorxiv.org/content/10.64898/2026.01.13.698514v1

Butyrate extends health and lifespan in mice with mitochondrial deficiency https://www.biorxiv.org/content/10.64898/2026.01.13.699287v1

Tuning siRNA Specificity through Seed Region Incorporation of Deoxyribonucleotide Stereoisomers https://www.biorxiv.org/content/10.64898/2026.01.13.699368v1

GapR is a nucleoid-associated protein that stiffens and overtwists DNA to promote transcription and replication https://www.biorxiv.org/content/10.64898/2026.01.13.699244v1

THE HIV-1 SILENCER BCL11B/CTIP2 REGULATES THE TLR3-MEDIATED CELLULAR RESPONSE TO VIRAL INFECTIONS https://www.biorxiv.org/content/10.64898/2026.01.13.699245v1

Type VI collagen is proportionally lower around airways and blood vessels in idiopathic pulmonary fibrosis https://www.biorxiv.org/content/10.64898/2026.01.13.698558v1

A micropeptide component of the OGDH complex modulates ATP production in the TCA cycle https://www.biorxiv.org/content/10.64898/2026.01.12.699137v1

Interplay of microRNA-20a and HuR in the regulation of beclin1 during Withaferin-A mediated impaired autophagy in Breast Cancer cell-line, MCF-7 https://www.biorxiv.org/content/10.64898/2026.01.13.699223v1

Molecular Mechanisms Associated With Amelioration Of Radiation Induced Gastrointestinal Mucositis By Compound Kushen Extracts https://www.biorxiv.org/content/10.64898/2026.01.12.698969v1

Maternal Trypanosoma cruzi infection is associated with significant placental remodeling regardless of vertical transmission https://www.biorxiv.org/content/10.64898/2026.01.13.699142v1

NFATc3 enhances DREAM complex-driven tumorigenesis https://www.biorxiv.org/content/10.64898/2026.01.12.699082v1

Comprehensive analysis of nonsense-mediated mRNA decay targets and activity in cardiomyocytes https://www.biorxiv.org/content/10.64898/2026.01.12.699048v1

A role for heavy chain-modification in protecting hyaluronan from free radical fragmentation during inflammation https://www.biorxiv.org/content/10.64898/2026.01.12.699012v1

HDAC inhibition via suberoylanilide hydroxamic acid (SAHA) ameliorates Doxorubicin-induced cardiotoxicity https://www.biorxiv.org/content/10.64898/2026.01.12.698976v1

The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomes https://www.biorxiv.org/content/10.64898/2026.01.12.698981v1

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15 https://www.biorxiv.org/content/10.64898/2026.01.12.698957v1

The Structured RNA-binding Domains and Condensation Capacity of FUS Shape its RNA-binding Landscape and Function. https://www.biorxiv.org/content/10.64898/2026.01.12.699057v1

EOLA1, a novel mitochondria-localized protein critical for heart functions via regulating mitochondrial translation https://www.biorxiv.org/content/10.64898/2026.01.12.699056v1

Multicellular signaling and partial recovery define reverse cardiac remodeling https://www.biorxiv.org/content/10.64898/2026.01.12.699040v1

Iterative engineering of a compact Cas9 ortholog for in vivo gene editing via single AAV delivery https://www.biorxiv.org/content/10.64898/2026.01.12.698990v1

Epigenetic Crosstalk Between BCG-Infected Macrophages and Naive Monocytes Potentiates Antimycobacterial Activity https://www.biorxiv.org/content/10.64898/2026.01.12.698601v1

Lysine acetylation facilitates competitive recruitment of translation termination factor eRF3a by PABPC1 C-terminal domain https://www.biorxiv.org/content/10.64898/2026.01.10.698208v1

Structural insights into the recognition and catalysis of tRNA by human NSUN2 https://www.biorxiv.org/content/10.64898/2026.01.09.698742v1

A highly stringent high-throughput screening assay for identifying transcription-modulating agents of HIV-1 latency https://www.biorxiv.org/content/10.64898/2026.01.07.698296v1

Molecular signatures and cellular responses underlying hypoxic adaptation in sea turtles https://www.biorxiv.org/content/10.64898/2026.01.09.698755v1

Ploidy-dependent modulation of DNA replication kinetics in Xenopus https://www.biorxiv.org/content/10.64898/2026.01.10.698760v1

MOV10 inhibits SADS-CoV replication by enhancing TRIM24-mediated K63-linked TRAF3 ubiquitination and this inhibition is antagonized by viral N protein https://www.biorxiv.org/content/10.64898/2026.01.09.698592v1

Heterogeneous causes of acute respiratory distress syndrome correlate with distinct peripheral polyunsaturated fatty acid metabolites https://www.biorxiv.org/content/10.64898/2026.01.09.698377v1

Mechanistic insights into E. coli recovery from growth arrest https://www.biorxiv.org/content/10.64898/2026.01.09.698670v1

In-Depth Characterization of Stem Cell Potency and Genotoxicity for Clinical-Scale Ex Vivo CRISPR/Cas9 Gene Editing https://www.biorxiv.org/content/10.64898/2026.01.08.698401v1

Chromatin context-dependent deacetylation by the asymmetric Rpd3L https://www.biorxiv.org/content/10.64898/2026.01.08.698523v1

PARP1 recruits SPRTN to DNA-protein crosslinks through a conserved poly-ADP-ribose binding domain. https://www.biorxiv.org/content/10.64898/2026.01.09.698661v1

Single-nucleotide resolution profiling reveals dynamic and site-specific m⁶A regulation during human myogenesis https://www.biorxiv.org/content/10.64898/2026.01.09.697937v1

Dual-mode ClfA-targeting DARPin biologics protect against diverse methicillin-resistant Staphylococcus aureus strains https://www.biorxiv.org/content/10.64898/2026.01.09.698026v1

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1 https://www.biorxiv.org/content/10.64898/2026.01.09.698382v1

Atomic resolution cryo-EM at 200 keV https://www.biorxiv.org/content/10.64898/2026.01.09.698548v1

Novel estimation of memory in molecular dynamics with extended and comprehensive single-molecule tracking software: FreeTrace https://www.biorxiv.org/content/10.64898/2026.01.08.698486v1