@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement. Great work by fantastic postdocs Lindsey and Reece (& student Maria) #PostdocAppreciationWeek www.biorxiv.org/content/10.1...

I've written to Keir Starmer, Kemi Badenoch and Nigel Farage, urging them to join me in condemning Elon Musk's dangerous remarks inciting violence yesterday. As leaders, we must stand together and make clear Musk will face serious consequences for these actions.

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels. www.nature.com/articles/s41...

Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org

Are you curious about what PLK1 kinase is up to these days? Have a look at our latest review on @cp-trendscellbio.bsky.social. Arianna Esposito Verza, @andrea-musacchio.bsky.social and I discuss the latest findings on a very important enzyme that is still full of surprises, 35+ years from discovery!

I'm excited to share our work on the regulation of endomitosis in worm intestines: www.biorxiv.org/content/10.1... We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators

Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism. www.nature.com/articles/s41...

Check out our latest work on cell cycle inhibitors, which has implications for how cancer cells could become resistant to these drugs #senescence #cellcycle #cancer 🧪 www.biorxiv.org/content/10.1...

Great article that make some very important points

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size (due to defects in cohesion and the mitotic checkpoint). Great work by fab PhD student Aanchal Pareri 👏🧪 www.biorxiv.org/content/10.1...

🔬 ⚕️ Research Assistant position open for highly motivated enthusiast of hematopoietic stem cell aging at Karolinska Institutet in Sweden 🇸🇪 😃 Please share 🙏 We are excited for your application! 😎 ki.varbi.com/en/what:job/...

This is fascinating… www.nature.com/articles/s41...

Registration is open for our Signalling Circuits in Cancer virtual conference! We're welcoming researchers from around the world to explore the dynamic signalling pathways that drive cancer development and progression. Submit your abstract and register: eacr.org/conference/s...

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

I'm happy to share our study “Proximity-based activation of AURORA A by MPS1 potentiates error correction” now published at @currentbiology.bsky.social www.sciencedirect.com/science/arti... It describes a new way kinetochores and centrosomes communicate to ensure accurate chromosome segregation.

Excited to share our latest preprint introducing BromoCatch - our cool new Tag solution for protein self-labeling inside cell. This should be a useful addition to the current arsenal of tools eg Halo, Snap. Link to the paper to catch your attention! => www.biorxiv.org/content/10.1...

I am excited to announce that my laboratory @ucl.ac.uk is now open! We are hiring so please contact us if you are interested. www.caswelllaboratory.com

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...

Extremely happy to share that my main PhD project about CIP2A-TOPBP1 and the SMX complex is now available online as pre-print. Huge thanks to all co-authors but especially @marcelvanvugt.bsky.social for giving me the opportunity to work on this exciting project! www.biorxiv.org/content/10.1...

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes. www.nature.com/articles/s41...

Don’t forget to register for the EMBO conference on phosphatases, July 27-31 2025 😊

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

Gender equality doesn’t just 'happen.' Women’s rights must be fought for and protected. Our responsibility is clear. To lead by example and create a world where opportunities are fair for all. Not just today, but every single day. #InternationalWomensDay

Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs. www.biorxiv.org/content/10.1...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection! institute-genetics-cancer.ed.ac.uk/igc-graduate...

Have another big post today on the importance of Bluesky/ATprotocol/decentralization, but also hoping to get people to understand the path forward is taking control over their own social media experience... www.techdirt.com/2025/01/27/e...

Please repost! We’re trying hard to sort out rumors from truth + would like to hear from anyone affected by the new federal orders + NIH pause. Patients, scientists, health equity researchers: please contact us below. We won’t share anything without your permission. www.statnews.com/2025/01/25/t...

What a great start to 2025 having our review on the role of hashtag#CDKs in human physiology and diseases just published in #Signal_Transduction_Targeted_Therapies! Here is the link to the open access article 👇 rdcu.be/d6a4g A big effort of the lab but we learnt a lot! I hope you will enjoy it

If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...

“This combination of evil and embarrassment is a unique horror, one that science fiction has failed to prepare us for.” 🤣 www.theguardian.com/commentisfre...

Congratulations to @andibrunner.bsky.social and the team, and many thanks to the lab of Jan-Michael Peters for support! We found that the interphase and mitotic chromatin loop organization have more in common than previously thought: In both stages big loops are built first, small ones second

Best start of 2025: our study on the dual role of CDKN2A in cancer evolution (rdcu.be/d5pty) is out in @naturecancer.bsky.social! Big thanks to Piyali Ganguli who led it, all coauthors and @cancerresearchuk.org archuk.org @crick.ac.uk @qmbci.bsky.social bci.bsky.social for support! Summary below

New Year, new paper! (Ok, it actually came out just before Christmas but who was working then?!) Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU

Cancer vaccines, living drugs, de-escalation, and more. A collection of this year’s biggest stories in cancer research and care, selected by the editors of Cancer Today. www.cancertodaymag.org/cancer-talk/...

Just in time for Christmas. Latest from the lab www.biorxiv.org/content/10.1... great collaborative effort with @nilssonlab.bsky.social @andrea-musacchio.bsky.social and Mathieu Bollen.

We know how bad habits/behaviors negatively affects our health and wellbeing in many different ways, but good habits/behaviors can have equally dramatic opposite results… This was such an illuminating and fascinating podcast with some very useful practical tips open.spotify.com/episode/0McO...

PATINA trial demonstrates benefit of palbociclib in HR+ HER2+ metastatic breast cancer www.news-medical.net/news/2024121...

We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10... It's a great team and a wonderful place to work!

Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...

Chronic social stress accelerates brain aging by causing neurons to enter a harmful "senescent" state, linked to inflammation and aging diseases, according to new research. #ChronicStress #BrainHealth #Neuroscience #MentalHealth #Aging

Beautiful study by Jacco van Rheenen, Colinda Scheele & team about the impact of the menstrual cycle on neoadjuvant chemotherapy in young women with breast cancer. Cutting-edge fundamental science with direct implications for women and families @nkinl.bsky.social www.nature.com/articles/s41...

If you’re interested in Zen Mediation or Mindfullness, here’s a hilarious description about detaching from the self that makes some serious points. Well worth the 15 min watch… m.youtube.com/watch?v=kRXJ...