Wafik S. El-Deiry, MD, PhD, FACP (@weldeiry.bsky.social)

Pleased to share collaborative study by Singh et al. from Professor Clark Chen’s group at @BrownMedicine #LegorretaCancerCenter Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance pubmed.ncbi.nlm.nih.gov/41217933/

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Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance - PubMed Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment. Here, we demonstrate that miR-181d modulates variability in methyl-guanine methyl transferase (MGMT) expression, contributing to this … https://pubmed.ncbi.nlm.nih.gov/41217933/