@marcelvanvugt.bsky.social
📤 601
📥 480
📝 21
make sure to check out this great meeting 👇
add a skeleton here at some point
5 days ago
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reposted by
Gerben Vader
19 days ago
Check out this beautiful paper by
@richardcsilva.bsky.social
et al., out now in
@natcomms.nature.com
. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
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Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications
DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...
https://www.nature.com/articles/s41467-025-65706-y
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reposted by
Luijsterburglab
28 days ago
Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗
dnarepairmeeting-egmond2026.com
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reposted by
Ernst Schmid
28 days ago
Thrilled to share that the final piece of my PhD work is now on bioRxiv!
biorxiv.org/content/10.1...
With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at
predictomes.org/hp
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Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
http://biorxiv.org/content/10.1101/2025.11.10.687652v1
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reposted by
GIIN
about 1 month ago
We are excited to welcome Evi Soutoglou and
@rubenvanboxtel.bsky.social
as our guest speakers at the upcoming GIIN webinar on Tuesday, November 4th at 5 PM Rome / 11 AM NYC. Join us on zoom:
uniroma1.zoom.us/j/95149984403
Register here to become part of our community:
docs.google.com/forms/d/e/1F...
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reposted by
Bert van de Kooij
4 months ago
We have an open position for a PhD student to join our team. If you have an interest in cancer biology, genome maintenance, or both, please apply! Details can be found in the link below. With
@marcelvanvugt.bsky.social
.
werkenbijumcg.nl/-/vacatures/...
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PhD student DNA repair in kidney cancer | Werken bij UMC Groningen
https://werkenbijumcg.nl/-/vacatures/phd-student-dna-repair-in-kidney-cancer/10419-02s0009tup
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reposted by
GIIN
7 months ago
The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair
@kajastelab.bsky.social
Join via Zoom:
uniroma1.zoom.us/j/95149984403
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Very exciting work by the Tijsterman lab
www.biorxiv.org/content/10.1...
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Mutational signature catalogue (MUSIC) of DNA double-strand break repair
Genome alterations arise from inaccurate DNA repair, accumulating into distinct mutational signatures. Here, we investigate the role of every genomically encoded gene in double-strand break (DSB) repa...
https://www.biorxiv.org/content/10.1101/2025.04.29.650617v1
7 months ago
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reposted by
Luijsterburglab
8 months ago
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it:
dnarepairmeeting-egmond2026.com
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reposted by
Luijsterburglab
8 months ago
@puckknipscheer.bsky.social
,
@luijsterburglab.bsky.social
,
@marcelvanvugt.bsky.social
,
@sylvie-noordermeer.bsky.social
,
@titiasixma.bsky.social
,
@marcelvanvugt.bsky.social
,
@marteijnlab.bsky.social
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reposted by
Lauren de Haan
8 months ago
Extremely happy to share that my main PhD project about CIP2A-TOPBP1 and the SMX complex is now available online as pre-print. Huge thanks to all co-authors but especially
@marcelvanvugt.bsky.social
for giving me the opportunity to work on this exciting project!
www.biorxiv.org/content/10.1...
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CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity
Perturbed DNA replication can lead to incompletely replicated DNA when cells enter mitosis and can interfere with chromosome segregation. Cells therefore require mechanisms to resolve these lesions du...
https://www.biorxiv.org/content/10.1101/2025.04.03.647079v1?ct=
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reposted by
Cell Reports
9 months ago
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
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REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
How cells ensure that they enter mitosis after completing replication of their genome is not fully resolved. Sobkowiak et al. describe a checkpoint involving REV7. This checkpoint has mechanistic similarities to the spindle anaphase checkpoint mediated by…
http://dlvr.it/TJcmfz
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reposted by
Tony Cesare
9 months ago
1/Out today in
@naturecomms.bsky.social
, “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41...
.
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A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications
Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...
https://www.nature.com/articles/s41467-025-57456-8
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Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher
@durocher1.bsky.social
and many others.
www.biorxiv.org/content/10.1...
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WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide inser...
https://www.biorxiv.org/content/10.1101/2025.03.12.642754v1
9 months ago
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reposted by
Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research
9 months ago
We show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome.
@icr.ac.uk
@cancerresearchuk.org
@breastcancernow.bsky.social
www.nature.com/articles/s41...
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The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics
Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.
https://www.nature.com/articles/s41588-025-02108-2
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reposted by
Anja Groth
10 months ago
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
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DNA replication and genome maintenance: from basic biology to disease
https://www.embl.org/about/info/course-and-conference-office/events/ees26-13/
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reposted by
Milo B. Fasken, Ph.D.
10 months ago
Nice resource!
#AlphaFold
#PPI
#ProteinInteractions
Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions: Molecular Cell
www.cell.com/molecular-ce...
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Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions
Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...
https://www.cell.com/molecular-cell/fulltext/S1097-2765%2825%2900105-4
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reposted by
Kurianlab
10 months ago
*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
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Professorship in genetics and molecular cell biology (W3) (f/m/d) - Academic Positions
The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its i...
https://academicpositions.com/ad/university-of-cologne/2025/professorship-in-genetics-and-molecular-cell-biology-w3-f-m-d/227902
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Beautiful work by the Lemmens lab!
www.biorxiv.org/content/10.1...
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Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures
DNA replication is essential to life and ensures the accurate transmission of genetic information, which is significantly disturbed during cancer development and chemotherapy. While DNA replication is...
https://www.biorxiv.org/content/10.1101/2025.02.21.639251v1
10 months ago
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exciting work: RNA-mediated tethering of DNA during mitosis
www.biorxiv.org/content/10.1...
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Mitotic transcription ensures ecDNA inheritance through chromosomal tethering
Extrachromosomal DNA (ecDNA) are circular DNA bodies that play critical roles in tumor progression and treatment resistance by amplifying oncogenes across a wide range of cancer types. ecDNA lack cent...
https://www.biorxiv.org/content/10.1101/2025.02.12.637945v1
10 months ago
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reposted by
The Groth lab
10 months ago
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth
@groth-anja.bsky.social
, Mailand, Nilsson
@nilssonlab.bsky.social
& Krietenstein
@nilskrietenstein.bsky.social
labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here:
tinyurl.com/yvd93na2
& please share!
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6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
https://tinyurl.com/yvd93na2
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reposted by
10 months ago
Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested:
[email protected]
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reposted by
Tony Cesare
10 months ago
Excited to present Social DNAing tomorrow. I’ll talk about our work led by
@szmyd-radoslaw.bsky.social
in collaboration with
@radoncdocgee.bsky.social
. 12 pm Eastern USA Thanks Shan Zha for the invite.
www.cancer.columbia.edu/research/pro...
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Social DNAing
Social DNAing Webinar Series, sponsored by the Cancer Genomics and Epigenomics Program at Columbia University, aims to provide a virtual meeting room for the genomic instability community worldwide.
https://www.cancer.columbia.edu/research/programs/cancer-genomics-and-epigenomics/social-dnaing
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reposted by
Nature Cancer
11 months ago
🌟Check out new online content: study from Daniel Dauch's lab:
doi.org/10.1038/s430...
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First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer - Nature Cancer
Rudalska et al. describe a novel class of p38α inhibitors with increased target residence time. They explore the drugs’ specificity, pharmacokinetics and toxicity profile and show that they are effica...
https://doi.org/10.1038/s43018-024-00899-7
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reposted by
Rémi Buisson
11 months ago
Today
@naturesmb.bsky.social
🥳, we report that the activation of NF-κB after DNA damage can occur through two distinct mechanisms. While ATM triggers NF-κB activation after DSBs, we found that IRAK1 specifically induces NF-κB in response to DNA damage causing transcriptional stress.
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ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage - Nature Structural & Molecular Biology
In this study, the authors show that DNA-damage-mediated transcriptional stress induces NF-κB through IRAK1, allowing damaged cells with impaired transcription to initiate an inflammatory response wit...
https://www.nature.com/articles/s41594-024-01417-0
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reposted by
Luijsterburglab
12 months ago
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here:
forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
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reposted by
Alex Carver
about 1 year ago
NEW in
@science.org
, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost!
#ScienceResearch
science.org/doi/10.1126/...
(1/7)
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Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filamen...
https://science.org/doi/10.1126/science.adr7920
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reposted by
Bill Dynan - NAR Cancer Editor
about 1 year ago
Announcing the NAR Cancer virtual 5th anniversary symposium: "Manipulating DNA repair and the DNA damage response to improve cancer therapy." First webinar Jan 9. In cooperation with Social DNAing at Columbia University. Read the program and register for free!
academic.oup.com/narcancer/pa...
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NAR Cancer 5th Anniversary Virtual Symposium
NAR Cancer is pleased to partner with the high-visibility Social DNAing webinar series, hosted by Columbia University, to present their 5th anniversary virtual
https://academic.oup.com/narcancer/pages/5th-anniversary-virtual-symposium-program
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reposted by
Orlando D. Schärer
about 1 year ago
What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics.
www.endodnadamage.com
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reposted by
Bill Dynan - NAR Cancer Editor
about 1 year ago
New at NAR Cancer: Ex vivo functional test for HR proficiency applied to a cohort of ovarian cancer PDX models: a way to identify PARPi-sensitive tumors lacking BRCA1/2 alterations. From Francien Talens et al., Univ of Groningen.
academic.oup.com/narcancer/ar...
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RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models
Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at
https://academic.oup.com/narcancer/article/6/4/zcae044/7912011
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Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models.
academic.oup.com/narcancer/ar...
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RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models
Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at
https://academic.oup.com/narcancer/article/6/4/zcae044/7912011
about 1 year ago
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reposted by
Aga Gambus
about 1 year ago
Two fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students.
t.co/WEJJIU4zU4
www.findaphd.com/phds/project...
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https://www.findaphd.com/phds/project/inhibitor-of-donson-gins-interaction-as-an-experimental-tool-and-potential-anticancer-strategy/?p178853
https://t.co/WEJJIU4zU4
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reposted by
Gabrielle Brewer
about 1 year ago
#Chromothripsis
leads to the acquisition of multiple genomic aberrations. Now out in Nat Rev Cancer: 1) A
#Review
from Simovic-Lorenz & Aurelie Ernst,
@dkfz.bsky.social
, covering mechanistic models of chromothripsis & its role in cancer and progression. 👉
bit.ly/4fy8pFo
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reposted by
Andrew Blackford
about 1 year ago
Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far
go.bsky.app/NvFWKvL
add a skeleton here at some point
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reposted by
Tatiana Moiseeva
about 1 year ago
ok, Genome Stability people. Here are our two starter packs - since I can't pin them both independently to my profile, have to make a new post. Still adding new people to the second pack. As usual, please reach out if you would like to be added!
bsky.app/starter-pack...
bsky.app/starter-pack...
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Today, the 12th annual PhD day for oncological research at the UMCG/University of Groningen is organized. Looking forward to great talks by PhD students and keynote speaker prof. Carla van Herpen!
about 1 year ago
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reposted by
Jeroen van den Berg
about 1 year ago
Very happy to see it out in the open! Congrats
@fmattiroli.bsky.social
🎉
add a skeleton here at some point
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reposted by
Mcclelland lab
about 1 year ago
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location
meetings.embo.org/event/25-ane...
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Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
https://meetings.embo.org/event/25-aneuploidy
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reposted by
Job Dekker
about 1 year ago
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
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https://www.cell.com/action/showPdf?pii=S0092-8674%2824%2901208-X
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