Are transcription-associated histone marks needed to restart transcription after DNA damage? We put this long-standing assumption to the test. With surprising results. Work with Janne van Schie, Bram de Groot & Diana van den Heuvel out in EMBO Reports 👇 link.springer.com/article/10.1...

Registration is now open for the 2026 Gordon Research Conference on Mutagenesis 🧬 📍 Waterville Valley, NH 📅 June 21–26 Theme: Next-Generation Views on Mutation Mechanisms and Their Impact 🎤 Short talks selected from abstracts 👉 www.grc.org/mutagenesis-...

Excited to share our latest study in Nature Communications ✨ We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track. Paper: www.nature.com/articles/s41... #Genomics #DNADamage #CellBiology

Our great collaboration with the lab of Wei Yang and Kaoru Sugasawa is now online in Nature. We’re glad we could contribute some cell biology to complement this beautiful structural and biochemical work. www.nature.com/articles/s41...

I really hate this sentence ....

This meeting comes highly recommended! Register soon!

Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

📣 Early-bird deadline approaching! 🧬 Register now for the DNA Repair Meeting in Egmond aan Zee • Apr 19–24, 2026 ⏳ Early-bird & abstract deadline: Jan 10, 2026 🔗 Program & registration: dnarepairmeeting-egmond2026.com Included: • 5-night stay • All meals • Full program See you there! 🌊

Fun X-mas party with the @luijsterburglab.bsky.social ! 🎉🎄🎅

To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026: The deadline for early registration is January 10th, 2026! 🗓️ Sign up soon to benefit from the early-bird registration fee 🐦💸 See you all in Egmond! 🌊✨

Our protocol for imaging-based quantification of RNAPII clearance during transcription-coupled DNA repair is now online. 👇 Well done, Bram, Diana, and Paula! star-protocols.cell.com/protocols/45...

A fun evening out with the lab!

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

New paper alert! 🚨 We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant. 👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity. www.sciencedirect.com/science/arti...

📢 ERCC1-hepatorenal syndrome is defined as a severe, multisystem DNA repair disorder associated with high morbidity and mortality, including an elevated cancer risk. 🧬 @luijsterburglab.bsky.social www.nature.com/articles/s41...

Dive into the step-by-step choreography of transcription-coupled DNA repair. In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research! www.nature.com/articles/s41...

Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org

Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells? Read the surprising outcome in our new preprint 👇 www.biorxiv.org/content/10.1...

Very proud of this international collaborative team effort published in EJHG defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators. www.nature.com/articles/s41...

📢 Only 2 more days left until the early bird registration deadline! Secure your spot and join us at the 8th EU-US Conference on Endogenous DNA Damage and Repair!

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

It was wonderful to have our lab symposium yesterday, filled with great science, new ideas, good company, and delicious food. What a pleasure it is to work with such a fantastic group of people!

Our letter-to-the-editor providing evidence that ARK2N is not a core factor in transcription-coupled DNA repair is now online in PNAS | www.pnas.org/doi/10.1073/...

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025/

Lovely Christmas party with the @luijsterburglab.bsky.social ! Looking forward to great science with this amazing group in 2025.

Our review on the recently discovered transcription-coupled DPC repair pathway is out in Trends in Cell Biology. Yet another wonderful collaboration with @cjcarnie.bsky.social and Steve Jackson.

It's a wrap! The 12th 3R+3C meeting in Fukuoka was amazing. Looking forward to the next edition!

Leaving Kyoto for the 3R+3C meeting in Fukuoka! Looking forward to great science, catching up with old friends, and making new ones.

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

En route to the 3R&3C meeting in Fukuoka, but first some time for sightseeing in Kyoto!

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by Diana, Marta and Paula! www.cell.com/cell/fulltex...