T-ALL is notoriously hard to treat due to the difficulty in distinguishing normal and malignant T cells. Now Fuentes et al. identify the pre-TCR as a biomarker for leukemia-initiating cells and develop a targeted immunotherapy for it. 📖👇

In a rare bout of personal news… I’m finally ready to be active on Bluesky again! Outside of my work-hours, I was a little busy planning a wedding with my cats’ dad 🐈🐈. Photo evidence below 🤭

Our FOCUS issue on #Ageing and Cancer is live! It features articles on: - age-induced metabolic reprogramming in cancer progression - modelling ageing-related cancer evolution - stromal senescence in age-related cancer Read it now: http://bit.ly/48uIDB...

Our SEPTEMBER issue is live! 🌤️🍂🌻🍂 It features articles on: - ER stress responses in anti-cancer immunity - Regulatory T cells in the TME - Metabolic adaptations of brain metastasis - Engineering strategies for nanoparticles Read it now👇 bit.ly/4mW1JnQ

Put on Tom & Jerry so my lil sidekick Leonard would let me work in peace. She was more into it than I thought she'd be 😹

🤩 It was a pleasure handling this article, and I am equally excited to see it out! Congrats!!!

Exercise induces microbiota to produce formate which in turn enhances CD8+ T cell anti-tumour functionality. 💪 #gains Check out my research highlight below for more deets 🤓🐛🧫

#REVIEW 🚨 #Nanoparticles can be engineered for targeted delivery of cancer therapies. Gomerdinger, Nabar & Hammond explore how surface chemistry drives delivery, targeting & localization. 📖 👇

August?! How did that happen?! I am still waiting for summer to arrive in Berlin😫 In any case, this issue is a goodie. Give it a read!! 🤓📖✨

In this Comment, Grünwald & Khokha call for a shift in comprehension of tumour tissue organization; while tumour tissues are heterogeneous, they are not disordered, & instead, propagate their functions via a considerable level of self-organization. 📖 👇 https://bit.ly/4nZaQ...

I previously volunteered w men returning from prison, where I saw how often adolescent hardships shaped their paths. Incarceration should not make someone undeserving of care & denying medical treatment reflects societal bias + ignorance. 📖⬇️ the barriers to equitable care for those behind bars.

A super cool Perspective highlighting the intersection of metabolic hallmarks of both aging and cancer. In it, they also explore how population-related metabolic differences associated with longevity may contribute to racial disparities in cancer risk & prognosis. Give it a read!! 🤓

pictured here is Leonard watching me watch AACR talks 😹

I will absolutely never understand why you would actively choose to turn off spell check on your Word document.😫 Look, we all make mistakes even with spell check on.... but I can tell you without a doubt that it would *defiantely* benefit you to keep it on.

Check out my latest research highlight 👇 While the presence of tertiary lymphoid structures (TLSs) in tumours is often linked with ⬆️response to IO, the maturation status can influence this. Now, Tang et al. uncover tryptophan metabolism as a factor determining TLS maturation status.

Nature Cuteness 🥹

REVIEW🚨 Rodriguez, Cubillos-Ruiz &Co discuss how the #ERstress response affects intratumoural immune cells & highlight the potential of #UPR-targeted interventions to improve cancer outcomes. 👀⬇️

A 'lil wknd readin' for ya 🤓🚨

Tbh, the Coral City Camera is easily my favourite account on bluesky. 😍

Here's some Monday morning reading for you 🤓

Check out my latest research highlight on work from Yingxiao Wang's group at USC. They engineered EchoBack CAR T cells, an ultrasound activated & genetically modified CAR T cell ("heard immunity" - get it?!) that enables precise spatiotemporal activation + tumour cell killing. 👂🧫👇📖

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Our June issue is now LIVE!🌞 It features articles on: - Challenges of SCLC heterogeneity & phenotypic plasticity - The fibroinflammatory response in #cancer - Moonlighting functions of glucose metabolic enzymes & metabolites in cancer - PIPKs in cancer 📖👇 www.nature.com/nrc/volumes/...

REVIEW 🚨 Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development + clinical translation continue to face challenges. Here, Zaidi, Jaffee & Yarchoan summarize this & highlight advances in the field. 📖 👇

AI Trick #1 for coming up new ideas: Think alone first! AI is persuasive – and able to spit out a lot of content quickly – so going to it first can severely constrain your ability to think differently. @emollick.bsky.social also talked about this on the @nightsciencepod.bsky.social.

Immune responses are complex, often defying rigid classifications. The authors of a Comment article in Nature Reviews Bioengineering argue that researchers should rely on comprehensive single-cell data to guide analysis and should remain open to unexpected immunological complexity. 🔒

A new study just dropped showing you can detect ultra-processed food intake through blood & urine metabolites 🤯 This is huge as self-reported diet data is notoriously unreliable (other studies show people think they eat healthier than they do!).

Melanoma exhibits distinct patterns of organ-specific spread. Gurung et al. find that age-based variations in stromal lipid species dictate melanoma metastatic tropism to the liver. @cruk-mi.bsky.social @officialuom.bsky.social 👇 #ResearchHighlight

Our latest Review, by Zaidi, Yarchoan & Jaffee, explores therapeutic cancer vaccines, highlighting why early attempts fell short, and how today's personalized, neoantigen-targeting vaccines are showing new promise. 🚨🤓👇

Wowowowowow. One more time for the people in the back: IT’S FREE!!! Don’t be shy, say hi 👇

Check out my latest #researchhighlight on new work published in @cp-cancercell.bsky.social by Gurung et al. They found that age-related variations in stromal lipid species dictate melanoma metastasis and tropism. 🤓 @cruk-mi.bsky.social @officialuom.bsky.social

Though I'm usually posting about papers I've accepted... today I'm posting about the publication of my own PhD work! The TLDR is that we used mechanobiological analyses to identify AhR as a mediator of TNBC CAF invasion. Big thanks to my co-authors! 💐🔬🧫🍾 www.sciencedirect.com/science/arti...

🙌🏼 good news for science and climate change and so many other things for Canada!!

Not to judge a magazine by its cover... but this month's issue is extra cute 😍 And bonus... the stuff on the inside isn't bad either😜 Happy reading!!

Well I'm back at work after 2 weeks of holiday and organizing a #NatureConference. The conference was filled with great science & great people. Below are some pics from the event, including one of Joao and I planting one of the three trees that Fran, Joao and I were honored with.

We have officially kicked off our #NatureConference here in Wenzhou, China. It's a pleasure to be here in beautiful Wenzhou! I am excited to learn 🤓

Leonard puts a new spin on "desk sharing"... Happy Friday ☀️💕

We just had an internal seminar from @daniela-oaks.bsky.social & @patriciapossik.bsky.social on acral melanoma in Latin America... it was one of those sessions that leaves you buzzing with questions and ideas! 🤓 Thanks @barbmarte.bsky.social for organizing.

Interesting panelist discussion at #KSTumorMetab25 on communicating science effectively to combat misinformation in this era. Check out this #WorldView that we, @natrevcancer.bsky.social, published from @juliabauman.bsky.social who posts 60-second TikToks explaining recent papers. bit.ly/41trLps

At the #KSTumorMetab25 meeting? Check out the latest review by Ayelet Erez & colleagues for more details on how metabolic interplay between the tumour & the host shape the tumour macroenvironment. 👀⬇️ bit.ly/3ReWTEo

Made it to beautiful Vancouver for the #KSTumorMetab25! ☀️

I made it to beautiful San Diego for the SITC meeting 🌦️ If you're attending and want to discuss anything @natrevcancer.bsky.social (or Nature Portfolio), please don't be a stranger 👋🏼

The effects of climate change are so much larger than the climate. In our latest #Comment, Weichenthal from @mcgill.ca, highlights the impact of wildfires on cancer development & outlines available + actionable solutions. Check it out 👇

It's #RareDiseaseDay! Check out our latest expert recommendation on appendix cancer.

It's March, already?! 🤯 Well the good news is that 1) you are in for a treat with our latest issue and 2) we're that much closer to spring!! Happy reading!

#RESEARCHHIGHLIGHT Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, in @cp-cancercell.bsky.social, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin. Read the highlight here 👇 https://bit.ly/4jL8W...

I fear that one of these days Microsoft Outlook is going to put me in a very awkward situation. I was going for more of a "I look forward to seeing the draft then" but hey, this is another option.🤷‍♀️

I had the pleasure of meeting these authors over dinner in beautiful Loutraki, Greece (@aegeanconf.bsky.social), where I learnt why research on pet cancer and on human cancer should be like this "🤝". Read their article below for the highlights.

Follow along as we count down our top 10 most downloaded articles of 2024! Any predictions for the remaining 8?! 👀

There is a special place in my heart for every potential referee who declines to review, but suggests good alternative referees.