GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:

Oh hey, looks like I can upload longer videos here now! Here’s my most recent one covering the latest findings on ecDNA retention mechanisms from the Chang & Mischel labs.

Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.

More updates on what’s happening to federally funded US science. Roughly the same magic touch Trump has brought to world trade, actually. Today’s examples are on drug-resistant gonorrhea and vaccine approvals, both of which are going to hell.

Any scientists want to help with a science communication project? Will reach thousands on TikTok! Details⬇️

www.nytimes.com/2025/04/03/o... Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

Gee, I wonder what that study on vaccines and autism will show www.washingtonpost.com/health/2025/... "Geier and his father, Mark Geier, have published papers claiming vaccines increase the risk of autism, a theory that has been studied for decades and scientifically debunked."

Interesting panelist discussion at #KSTumorMetab25 on communicating science effectively to combat misinformation in this era. Check out this #WorldView that we, @natrevcancer.bsky.social, published from @juliabauman.bsky.social who posts 60-second TikToks explaining recent papers. bit.ly/41trLps

I know Twitter sucks but it’s a *great* time to try to spread messages about harms to US science to non-academics

Glad to see this post getting some traction, because the Federal Register is the WHOLE ballgame, folks. To drive this point home, a recent EO declares that all posts to FR now must be approved by the White House. www.whitehouse.gov/presidential...

I have had a TON of people asking how they can help...here is what would help us the most right now: SHARE SHARE SHARE SHARE SHARE! Tell us why you #standupforscience2025! Send flyers to your colleagues and labs! Change your bluesky banner! Tell your professional orgs and departments!

Cuts to the NIH are a strategy to strangle research universities not “reduce waste”

It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members. 5calls.org

Insanely good news if this holds up. Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor www.science.org/doi/10.1126/...

Took me 3 minutes to call both of my Senators and my representative. Just do it.

Our paper is out!! TLDR; Cell Painting as a phenotypic readout in whole-genome CRISPR screens is very informative, cheap per cell, & we find some interesting biology!

Dying for a bookmark function on @bsky.app! How else am I supposed to add to my massive list of unread papers 😰

www.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

If the idea of an RFK Jr. HHS Secretary (or any of the other scientific/medical agency appointees) is concerning to you, contact your senators to express your worries. Feel free to borrow my template below:

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene www.sciencedirect.com/science/arti...

Good news: You can post video on Bluesky now! Bad news: Only up to 60s. So here’s a clipped version of my latest video about a paper exploring the landscape of possible molecular glue degradation targets:

*begins exploring jobs in Switzerland*

How did I just find out that Nature publishes weekly sci-fi stories?! is this news to anyone else or am I just way behind

Not being able to post video largely defeats my purpose for being here but it also makes my browsing experience better… I feel conflicted by this🙃