How can we scale subcellular spatial proteomics across many experiments and conditions? Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.

9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

Happy to share our latest research on the BRCA1-BRCTs now online. academic.oup.com/nar/article/... Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

Job Alert 🚨 Are you an emerging leader in biomedical discovery or population health data science? We are looking for outstanding candidates to join our institute! Learn more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529

New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force. biorxiv.org/content/10.1... @standardbiology.bsky.social #SpatialBio #IMC

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Welcome Alissa! We are very excited to have you with us!

Teaching stream faculty position in molecular genetics! jobs.utoronto.ca/job/Toronto-...

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3) www.biorxiv.org/content/10.1...

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social). jobs.sciencecareers.org/job/673968/p...

🇨🇦🚨Job alert🚨🇨🇦 We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...

Thanks for the wonderful conference @agnelsfeir.bsky.social @chowdhurylab.bsky.social and Karlene!

FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK! www.embopress.org/doi/full/10....

⏰🚨FINAL DEADLINE APPROACHING #BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬! Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

We are looking to recruit three posts at the @crick.ac.uk in structural biology, cell biology, and pharmacology to join a 20+ strong multidisciplinary team focused on delivering the first precision medicines for the treatment of ALT cancers. Interested? Please check out the advertised jobs below:

Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!

UHN marks the passing of Dr. James Till, whose work with Dr. Ernest McCulloch first demonstrated the existence of blood-forming stem cells in 1961 at Ontario Cancer Institute, now Princess Margaret Cancer Centre. His work has helped launch the field of #stemcell science.

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

I love this so much. ♥️ thanks to all of those involved in this project.

Implement a 100% tariff and ruin a movie. Friday the 26th

Remembering Adam Yauch aka MCA August 5, 1964 - May 4, 2012 Beastie Boys HD : Sabotage ( David Letterman ) - 1994 #hardcorepunk #hiphop #mca #adamyauch #beastieboys #history #punkrockhistory #otd

Wonderful work from Rod Bremner and his team at the Lunenfeld-Tanenbaum Research Institute, @sinaihealth.bsky.social

Had to be done (apologies if similar memes have been shared)

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

Congrats @danieljdrucker.bsky.social ! www.theglobeandmail.com/canada/artic...

If you're watching what's happening at US universities, it's on our doorstep here. Pollievre is promising to end federal funding for research deemed to be "woke" www.montrealgazette.com/news/canada/...

📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED! 💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts! 🧑‍💼Our short talk submission deadline has been extended and will now close on 01 April. Submit your abstract HERE: bit.ly/3AnsVZF

We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️

Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...

Uber should offer a “no tesla” option

Hour of Suffering by Jean-Paul Riopelle, 1953 https://botfrens.com/collections/212/contents/137278

@mark-carney.bsky.social Mr. Carney, regarding your plan to reduce federal "spending" but increase "investments": in which category do you put federal support for research and innovation? Do you see it as an expense or an investment?

Portuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.

🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation. Apply ➡️ apply.interfolio.com/162929 or DM with questions!

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

There is clearly enough bullshit in the US to fertilize the fields of Iowa