Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers link.springer.com/article/10.1...

We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️

Great conference, great science and great location!

Maple syrup under a microscope. That is why Canadians are so happy, we literally eat glitter. 😊 #Canada

The original Freaky Friday

Fresh off the press, my latest YouTube extravaganza, sponsored by the Wendover tourist board

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org

Canada 🇨🇦 vs US 🇺🇸 Olympic gold medal final overtime

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!

To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026: The deadline for early registration is January 10th, 2026! 🗓️ Sign up soon to benefit from the early-bird registration fee 🐦💸 See you all in Egmond! 🌊✨

That will be fun to explore!

How can we scale subcellular spatial proteomics across many experiments and conditions? Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.

9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

Happy to share our latest research on the BRCA1-BRCTs now online. academic.oup.com/nar/article/... Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

Job Alert 🚨 Are you an emerging leader in biomedical discovery or population health data science? We are looking for outstanding candidates to join our institute! Learn more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529

New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force. biorxiv.org/content/10.1... @standardbiology.bsky.social #SpatialBio #IMC

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Welcome Alissa! We are very excited to have you with us!

Teaching stream faculty position in molecular genetics! jobs.utoronto.ca/job/Toronto-...

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3) www.biorxiv.org/content/10.1...

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social). jobs.sciencecareers.org/job/673968/p...

🇨🇦🚨Job alert🚨🇨🇦 We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...

Thanks for the wonderful conference @agnelsfeir.bsky.social @chowdhurylab.bsky.social and Karlene!

FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK! www.embopress.org/doi/full/10....

⏰🚨FINAL DEADLINE APPROACHING #BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬! Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

We are looking to recruit three posts at the @crick.ac.uk in structural biology, cell biology, and pharmacology to join a 20+ strong multidisciplinary team focused on delivering the first precision medicines for the treatment of ALT cancers. Interested? Please check out the advertised jobs below:

Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!

UHN marks the passing of Dr. James Till, whose work with Dr. Ernest McCulloch first demonstrated the existence of blood-forming stem cells in 1961 at Ontario Cancer Institute, now Princess Margaret Cancer Centre. His work has helped launch the field of #stemcell science.

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

I love this so much. ♥️ thanks to all of those involved in this project.

Implement a 100% tariff and ruin a movie. Friday the 26th

Remembering Adam Yauch aka MCA August 5, 1964 - May 4, 2012 Beastie Boys HD : Sabotage ( David Letterman ) - 1994 #hardcorepunk #hiphop #mca #adamyauch #beastieboys #history #punkrockhistory #otd

Wonderful work from Rod Bremner and his team at the Lunenfeld-Tanenbaum Research Institute, @sinaihealth.bsky.social

Had to be done (apologies if similar memes have been shared)

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

Congrats @danieljdrucker.bsky.social ! www.theglobeandmail.com/canada/artic...

If you're watching what's happening at US universities, it's on our doorstep here. Pollievre is promising to end federal funding for research deemed to be "woke" www.montrealgazette.com/news/canada/...