Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Great collaboration with @gingraslab.bsky.social & congrats to lead author Vesal. Paper: www.nature.com/articles/s41... Thanks to @sinaihealth.bsky.social

New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force. biorxiv.org/content/10.1... @standardbiology.bsky.social #SpatialBio #IMC

🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦 Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area. 👉 apply.interfolio.com/168307

Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer. www.nature.com/articles/d41...

🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation. Apply ➡️ apply.interfolio.com/162929 or DM with questions!

Canada at this point needs to double research money to become a true powerhouse. In terms of dollars, it’s not a lot to get there. A visionary government would leap at the chance. Alas no party in Canada has that vision. Most institutions are freezing hiring (in ON anyways).

So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩 www.nature.com/articles/s41... A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social 🧵👇:

Need better clusters from your segmented single cell data? Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells. Great and highly useful work by Jett Lee!

in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2

Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.

Ever wondered how gut microbes control immune responses at extra-intestinal locations? Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria. @cellpress.bsky.social ⬇️(1/x) www.cell.com/cell/fulltex...

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology. 1/ www.nature.com/articles/s41...

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1

One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab

Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq

#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW

Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.

Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months! ome.github.io/ome2024-ngff...

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬

Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.