Hart Jackson
@hartjackson.bsky.social
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Investigator at LTRI, Uni Toronto. Spatial bio & methods.
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Hart Jackson
Zebrafish Rock!
29 days ago
Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to
@helenfarrants.bsky.social
, William "Bill" Lemon, & Philipp Keller at
@hhmijanelia.bsky.social
.
#ZebrafishZunday
🧪
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Mikko Taipale
about 1 month ago
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration.
www.nature.com/naturecareer...
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POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
https://www.nature.com/naturecareers/job/12849004/postdoctoral-fellow
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Hart Jackson
Kieran Campbell
2 months ago
Great collaboration with
@gingraslab.bsky.social
& congrats to lead author Vesal. Paper:
www.nature.com/articles/s41...
Thanks to
@sinaihealth.bsky.social
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Hart Jackson
Jim Mansfield
4 months ago
New from
@hartjackson.bsky.social
: 104‑plex
#IMC
on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social
#SpatialBio
#IMC
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Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour–microenvironment interactions within t...
https://biorxiv.org/content/10.1101/2025.08.15.670565v1
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Hart Jackson
Kieran Campbell
7 months ago
🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦 Exciting postdoc joint with
@hartjackson.bsky.social
developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area. 👉
apply.interfolio.com/168307
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/168307
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Hart Jackson
Eric Topol
8 months ago
Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer.
www.nature.com/articles/d41...
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The cell-division cycle is faster in cell types prone to forming cancer
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
https://www.nature.com/articles/d41586-025-01138-4
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Hart Jackson
Kieran Campbell
11 months ago
🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with
@durocher1.bsky.social
at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation. Apply ➡️
apply.interfolio.com/162929
or DM with questions!
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/162929
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Hart Jackson
Ravi Menon
11 months ago
Canada at this point needs to double research money to become a true powerhouse. In terms of dollars, it’s not a lot to get there. A visionary government would leap at the chance. Alas no party in Canada has that vision. Most institutions are freezing hiring (in ON anyways).
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Hart Jackson
Veronica Rendo
11 months ago
So excited to see our paper describing the class of ARGOS genes in cancer out in
@naturecomms.bsky.social
! 🤩
www.nature.com/articles/s41...
A giant effort led with
@ms01.bsky.social
and executed under the mentorship of
@bendavidlab.bsky.social
@rameenberoukhim.bsky.social
@foijer-lab.bsky.social
🧵👇:
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A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer - Nature Communications
In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tum...
https://nature.com/articles/s41467-025-56301-2
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Need better clusters from your segmented single cell data? Check out our new method with
@kieranrcampbell.bsky.social
for unsupervised correction of imperfectly segmented cells. Great and highly useful work by Jett Lee!
add a skeleton here at some point
12 months ago
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Hart Jackson
Richard.
about 1 year ago
in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2
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Hart Jackson
The Ferrari Lab
about 1 year ago
Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.
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Hart Jackson
Arthur Mortha
about 1 year ago
Ever wondered how gut microbes control immune responses at extra-intestinal locations? Here
#theonlylabever
reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social
⬇️(1/x)
www.cell.com/cell/fulltex...
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Hart Jackson
Ulrich Elling
about 1 year ago
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology. 1/
www.nature.com/articles/s41...
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CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.
https://www.nature.com/articles/s41587-024-02512-9
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Hart Jackson
bioRxiv Cancer Bio
about 1 year ago
Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
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Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
The tumor microenvironment (TME) is a complex network of interactions between malignant and host cel
https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
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Hart Jackson
Craig Kaplan
about 1 year ago
One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab
add a skeleton here at some point
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Hart Jackson
Tineke Lenstra
about 1 year ago
Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs.
bit.ly/3O4bOjq
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Hart Jackson
Anirban Maitra
about 1 year ago
#PancreaticCancer
research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss?
go.bsky.app/FDafAW
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Hart Jackson
Perrine Paul-Gilloteaux
about 1 year ago
Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.
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Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!
about 1 year ago
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Hart Jackson
Daniel Durocher
about 1 year ago
First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1:
www.cell.com/molecular-ce...
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Profound synthetic lethality between SMARCAL1 and FANCM
Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1 and FANCM. Their combined loss leads to catastrophic genome instability, particularly at simple-repeat sequence...
https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00856-6?rss=yes&utm_medium=twitter&utm_source=dlvr.it
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Hart Jackson
Erick Ratamero
about 1 year ago
I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months!
ome.github.io/ome2024-ngff...
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Hart Jackson
Daniela Barillà
about 1 year ago
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬
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Hart Jackson
Nicole Rust
almost 2 years ago
Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.
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Hart Jackson
BostonJoan 🏳️🌈 🦫
almost 2 years ago
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