Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Great collaboration with @gingraslab.bsky.social & congrats to lead author Vesal. Paper: www.nature.com/articles/s41... Thanks to @sinaihealth.bsky.social

New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force. biorxiv.org/content/10.1... @standardbiology.bsky.social #SpatialBio #IMC

🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦 Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area. 👉 apply.interfolio.com/168307

Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer. www.nature.com/articles/d41...

🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation. Apply ➡️ apply.interfolio.com/162929 or DM with questions!

So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩 www.nature.com/articles/s41... A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social 🧵👇:

Need better clusters from your segmented single cell data? Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells. Great and highly useful work by Jett Lee!

in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2

Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.

Ever wondered how gut microbes control immune responses at extra-intestinal locations? Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria. @cellpress.bsky.social ⬇️(1/x) www.cell.com/cell/fulltex...

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology. 1/ www.nature.com/articles/s41...

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1

One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab

Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq

#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW

Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.

Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months! ome.github.io/ome2024-ngff...

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬

Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.