The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Congratulations to everyone but especially Venda & Sylvie for this nice work and thanks to Andrea Murachelli in my lab for his analyses

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK

In the context of our @reviewcommons.org revision process, I'm happy to announce Microscopy Nodes v2.2.0! This packs lots of new fun features, including new color management 🌈, clearer transparency handling 🫥, custom default settings 🔧 and more! Preprint at doi.org/10.1101/2025...

This is accompanied by a new set of tutorials showing exactly how you can start making beautiful microscopy visualizations in @blender.org! Following along is also easy with the example OME-Zarr @openmicroscopy.org datasets 😄 Find the tutorials here: www.youtube.com/playlist?lis...

LocScale-SURFER is now also available for quick install via the ChimeraX toolshed: cxtoolshed.rbvi.ucsf.edu

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

In what world you can justify firing Richard Youle?!? #autophagy #mitophagy www.wired.com/story/doctor...

Trump's 3/27 executive order targets the Smithsonian for advancing "the view that race is not a biological reality but a social construct." Trump argues that the exhibit's statement, below, is unscientific. He's wrong. As a biology professor and population geneticist, I agree with every word of it.

Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.

great to see it out, Irina!

"The rejection of grant applications or the alteration of the published record on account of the use of terms such as ‘bias’, ‘gender’, ‘ethnicity’ and even ‘female’ is unacceptable. EMBO Press joins other journals in not allowing such changes" 💪🏻👏🏻👏🏻👏🏻 www.embopress.org/doi/full/10....

It's infinitely sad to see what is happening. the disregard of laws, advice and justice in our immigration policy plans, the total implosion of human values overseas. I feel just a bystander reeling in shock.

Today Jan Drenth would have been 100 years, but sadly he passed away last week. He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.

Today, the same as every other damn day, trans rights are human rights

Are you graduating this year and ready to start your career in the most meaningful way? This is your chance to get on board. #PhD #CancerResearch ➡️ nki.nl/careers-study/phd-students/nki-phd-program-2025/

I am really excited to have the opportunity to continue to do science at the Hubrecht Institute @hubrechtinstitute.bsky.social! Thank you for the support!

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

The NKI call for PhD students is now open, with more information on our project on the website, More info: bit.ly/3O4bOjq

Despite the black picture below, we're really happy to have this illuminating story online! Careful molecular mechanistic from Niels and others in the lab work giving unexpected biological insight!

We have an opening for a PhD student, for a cryo-EM/biochemistry project at the interface of ubiquitin and DNA repair. Enthousiasm and experience with protein biochemistry and/or structural biology really important. Recruitment will fall under the the NKI PhD program, please see below

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. www.biorxiv.org/content/10.1...

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

It was Tony Crowther whose advice I still hold dearly: "Don't worry about the journal, it will still be the same science you are publishing somewhere else."

Great meeting of the RepliFate doctoral Network, lots of science and fun, great interactions and even better organization by @titiasixma.bsky.social

Next up, microscopy nodes for Blender, made by @grosoane.bsky.social, which lets you import microscopy images as efficient voxel representations for generating animations (ie below, from EMPIAR-10982). I've had a lot of fun playing around with it the last couple of weeks. github.com/oanegros/Mic...

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

STK19 Transcription coupled repair With TFIIH #ChromatinHaiku www.cell.com/cell/fulltex... www.cell.com/cell/fulltex... www.cell.com/molecular-ce...

Great to see this out: STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment Great collaboration with Jurgen Marteijn and Anisha Ramadhin; All biochem.and #cryoEM by Shun-Hsiao Lee: www.cell.com/molecular-ce...