#chembio and #bioorganic crowd: Registration to ESBOC is open. Join us on 27th-29th May for the oldest meeting in chemical biology in Europe, at the awesome Schlosshotel Pillnitz in Dresden! Check out www.esboc.org.uk or register directly at eveeno.com/esboc2026!

FOR THE RECORD: one year on, I lay out clearly how Elon Musk FRS has breached the @royalsociety.org’s code of conduct, why the Society’s failure to defend its values has been so damaging, & what they need do to recover their standing in the scientific community. occamstypewriter.org/scurry/2026/...

Even when the focus is on research with immediate industrial applications, many policymakers recognise that breakthroughs start with fundamental science. That's why Mario Draghi recommended doubling the ERC’s budget. ERC President spoke at @sciencebusiness.net Annual Conference earlier this week.

😂

Hello sunshine ☀️😎 and yes, the sky is still blue in the southern hemisphere 💙🇦🇺

“Continued global heating could trigger climate tipping points, leading to a cascade of further tipping points & feedback loops..The climate would be very different to the benign conditions of the past 11,000 years, during which..human civilisation developed” www.theguardian.com/environment/...

I remember the fear and confusion of those early days when Gretchen Vogel and I were trying to make sense of the reports. And I have to say that reading a scientific paper has rarely given me the sense of satisfaction that this piece of scientific sleuthing did. www.nejm.org/doi/full/10....

I will say: What we have learnt in the past five years about what went wrong in terms of cells and molecules is really impressive. I wish I could say the same about what we have learnt in the past five years about what went wrong in terms of communications.

Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved. 
 It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪

“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline” www.science.org/doi/10.1126/...

Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...

On this International Day of Women and Girls in Science I (as in previous years) take an Implicit Association Test to remind myself of my potential biases and with the goal of remembering to take them into account You too can do this at: implicit.harvard.edu/implicit/

Imagine! I mean, imagine how hard it is for a quadratic equation to understand itself! Imagine how hard it is for that statement to have any meaning whatsoever!

something to digest... ;-)

That "ivermectin has become a symbol of resistance against the medical establishment among conservatives" is insane. Meanwhile "appalled...It’s absurd” isn't an NCI judgment one wants about a proposed study. Cancer folk, is there any justification for the study? kffhealthnews.org/news/article...

Pretty neat. Here’s some images of the #teammasssprc community.

A content warning for very, very significant police violence on this video: Israeli President Herzog is visiting Australia, and police in New South Wales are violently bashing prone protesters. The media is framing it in completely neutral terms. Watch the video, then look at the headlines.

Dear friends and colleagues, I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs). www.biorxiv.org/content/10.6... 👀

It's not even midnight and we're already at "Deport Elmo."

We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out! www.biorxiv.org/content/10.6...

I'm convinced AI is our generation's radium - a discovery with genuinely useful applications in specific, controlled circumstances that we stupidly put in everything from kid's toys to toothpaste until we realised the harm far too late where future generations will ask if we were out of our minds.

This is an example where AI can greatly help advancing healthcare through early diagnosis ⬇️ what it sees/how is less important when training is done on consistent and complete data sets, necessary to increase signal to (real) noise. Fab! @erictopol.bsky.social open.substack.com/pub/erictopo...

ChatGPT assumed I am male. The reason demonstrates we have work to do. #AI #tech

Great @zeblarson.bsky.social piece - much more from me coming soon on big tech greenwashing When I have time I will properly put together my notes and work on the bluewashing / minimisation of water impacts being spun by effective altruists on data centres too - wild how much cut-through it has had

This a word cloud from the titles of ~1100 terminated NSF grants. It is hard not to see these grant terminations as an attack on the training of the future United States scientific workforce.

A near-complete map of human cytosolic degrons and their relevance for disease We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence Led by @vvouts.bsky.social in @rhp-lab.bsky.social doi.org/10.1126/scia...

Fabulous talk by @fabianruperti.bsky.social in the #LorneProteomics2026 #glycotime session on the evolution and diversity of N-glycosylation in animals

Now published in @science.org www.science.org/doi/10.1126/...

"What I can’t actually believe it has the barefaced gall to still have that phrase on its masthead though I liked this take from the Reductress, titled: The Washington Post Lays Off Half Its Slogan" @carolecadwalla.bsky.social ⬇️👏🏻 👏🏻 open.substack.com/pub/broligar...

Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now? www.science.org/content/arti... It’s pretty wild, at least by typical academic journal editorial office standards.

@mikefeigin.bsky.social’s favorite bioRxiv experience was being able to start a collaboration based on reading a preprint, leading to a publication years later. As an Affiliate, he helps these impactful preprints be posted ~48 hours post-submission #openRxiv #OpenScience #preprints #CommunityVoices

Listen to the second installment of the Lost Women of Science podcast series Layers of Brilliance digging into the life of Katharine Burr Blodgett, who began her career at the "House of Magic"

🧪🥺 search.app/9hgv2

Amazing 🇦🇺 #glycotime 🧪⬇️

🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

Really happy to see this work out! Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).

‘Study after study shows that students want to develop these critical thinking skills, are not lazy, and large numbers of them would be in favor of banning ChatGPT and similar tools in universities’, says @olivia.science www.ru.nl/en/research/...

I’m having a hard time thinking of an interview between two human beings I enjoyed more than tonight’s interview of the great Ian McKellen by the great Stephen Colbert. Every moment of it was a pleasure that I highly recommend… but then came the most REMARKABLE ending that you really HAVE to watch.

'Still, publishing a review —often with its own DOI—raises questions about the review’s legal status as a standalone scholarly item as it could belong to the reviewer, the publisher or both, or enters the public domain under a CC license with unclear rights about who is allowed to do what.'

Aside from the obvious reasons, there is also this 👇🏻👏🏻

Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social

As replacing your brain + a good search on Google Scholar, this may be a useful LLM tool, except that "it does not consistently retrieve the most representative or relevant papers for certain queries" 🤔 and why is this in Nature, again? 🤔🤔 www.nature.com/articles/s41...

Great story on Seung-Wuk Lee’s work on virus particle-based materials @berkeleyengineer.bsky.social #proudofalumni

Landing in Dunedin Aotearoa in about 90 minutes for the start of a trip that represents the culmination of a dream I’ve had since I was ten years old.

INBOX: Robert McCartney, who worked for 39 years at The Washington Post, including as a Metro columnist and editor, before retiring in 2021, claims on X that he has heard the Post has laid off *all* its photojournalists.

In no functioning country is this allowed.

Welcome, piles of slop filling up the journals with clouds of useless wordy garbage. Case in point:

PaperBanana: Automating Academic Illustration for AI Scientists doi.org/10.48550/arX... dwzhu-pku.github.io/PaperBanana/

🚨BREAKING: The UK economy would be 3.6% smaller by 2040 if net migration fell to zero, forcing the government to raise taxes to combat a much bigger budget deficit, a thinktank has predicted. www.theguardian.com/business/202...

“Back then there was a clear national vision for universities, and they were mostly publicly funded,” he says. “Now you stand or fall on your student demand.” On the societal impact of unis that need (now more than ever) the support of a forward-looking government! Innovation is built on education