Just watched the new Knives Out and I think it's really important you know that the scene in the Seminary's Gym is filmed in the same place Rick Astley filmed the music video for Never Gonna Give You Up. I saw the window tracery and immediately made my friends pause the film so I could tell them.

A very, very short blogpost about my favourite photos of the year occamstypewriter.org/scurry/2025/...

If you use kagi.com for your search, there's a setting to block AI images. Immensely useful. And you can block internet domains - so for example I've blocked Amazon. No Amazon results at all in my searches. No ads. No bullshit SEO. Just pure, clean search results. It really is a revelation.

Kangaroos have a remarkable ability to speed up without burning extra energy. Clever posture changes let their tendons store and return extra elastic energy, acting like natural springs and keeping the metabolic cost almost flat even at higher speeds. buff.ly/JGx98pe

I tell students that one of the crudest mistakes made in public policy is to overlook the fact that people will react to changes in ways that you might not have taken into account. And in retrospect it can look oh so predictable which makes it even more embarrassing.

Next 7-days on 12z UKMO. I don’t think you need to be proficient in model interpretation to know the direction of travel as long as you know where we are on the map….. 🥶🥶

Just in case you're wondering, today is Sunday.

The Error Bar #ChemSky #ChemChat

If Martin Kettle would have read the great book Humankind by @rutgerbregman.com, this story would not have come as a surprise. Anyway, it is good he realises that journalists, including himself, are partially to blame for our skewed understanding of society. www.theguardian.com/commentisfre...

Alright, fellow authors, let’s do this.

1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch? And we mean scratch: a blinded study. TLDR: 26 days. And the binders work…and led to new cancer biology. We’re coming for you AI…. chemrxiv.org/engage/chemr...

Imagine watching Sinatra, son of Dolly & Antonini born in Genoa & Sicily, respectively, and Martin, son of Gaetano & Angela, born in Montesilvano, Italy & Ohio respectively, (Angela to parents born in Monasterolo, Italy), and crusading against the value of children of immigrants to the U.S.

Make a Bond movie academic For Your Eyes Only: paywalled journals and global scientific inequity

Presenting DGlyTACs—comprising a fusion protein consisting of peptide-N-glycosidase F (PNGase F) and a target-specific #nanobody/affibody (Nb/Af)—as a novel technique for removing N-glycans from target #glycoproteins on the cell surface. #STTT #OpenAccess: doi.org/10.1038/s413...

“if you ask [LLMs] for factual information you don't have any guarantee it's going to be correct…not a good idea to rely on them for information you can't verify and that's somehow important” www.bbc.com/news/article...

Record warming met weak political resolve as climate pressures mounted this year.

One port, one cable, one Europe. This holiday, unwrap the power of one: USB-C for all. Yes, not just phones, tablets, and laptops. In three years, every charger will be under the same tree. Because less waste, smarter choices, mean more for everyone, all year long. link.europa.eu/QDMFTh

Merry christmas one and all. I'll be on here throughout the day with #joinin if you need some company. Cat pictures welcome. Use the #joinin hashtag and jump in. Get chatting and be kind ❤️

Merry Christmas - get stuck in!

I wish you a Happy Christmas and a coming year of solidarity and resistance. Love and courage to you all.

Tonight is Christmas Eve, when we in Iceland open presents. All the Yule Lads have already come down from the mountains, but tonight the Yule Cat arrives and he will eat all the children who weren't gifted any new clothes for Christmas. My daughters both got woollen socks so they are safe 🙏

If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!

🔥 THIS IS HUGE! Horizon is the world’s science programme, hosted by the EU. It just got bigger. Other non-European countries associated to the programme (ie paying in) include Korea, New Zealand, Canada.

Telling good science from bad – a user’s guide to navigating the scientific literature www.wiringthebrain.com/2021/08/tell...

Drude SILCS-Nucleic: Harnessing Explicit Electronic Polarization in Targeting RNA and DNA for Drug Design https://www.biorxiv.org/content/10.64898/2025.12.20.695737v1

#compchem #compbio Last preprint of the year: "Fast, systematic and robust relative binding free energies for simple and complex transformations : dual-LAO". arxiv.org/abs/2512.17624 Great work by N. Ansari. @qubit-pharma.bsky.social . Another nice collab with J. Hénin.

ChatGPTzero says my abstract (written preLLMs) has a "high" probability of being written by AI: "consistently formal tone, smooth logical progression...lack of idiosyncratic stylistic variation...coherent and well-structured" IOW written by an editor... journals.plos.org/plosbiology/...

Journals: Please don't submit papers in the last second before the new year we can't find reviewers Me: submitting a paper

At Volcano National Park. Kiaulea is about to blow!

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

My Christmas holiday read will be Helm by Sarah Hall, but here's a gift article with some other great suggestions too: 📚📚📚📚 www.nytimes.com/2025/12/18/b...

It's #StrangerThings Christmas marathon time!! 🍿😎🍿😎

Photo of #lichen, #moss and some frosty little vascular #plants like lingonberry and crowberry. Kind of has an ”under water” feel to it. #newfoundland Canada.

Unfortunately there are no #parkrun here at home 😔 so I make my own, the SuzyQ Parkrun, where I always win and where there's a lovely mineral at the end 😎🍻

✨ Our first reactions article in @ACSCentralScience with #CyrilGoudet is officially out! 🎉 pubs.acs.org/doi/10.1021/... Don’t miss the chance to dive into the fantastic work of #AmadeuLlebaria #Xavier Rovira and #VenkateshKrishnan – truly a great read for the winter break! ❄️ 💛 #ProfLife #ChemBio

Last X-Mas, the ribosome gave you methionine, but the very next day, MetAP took it away. This year, to save histones from tears, NatD gives you an acetyl group. ⭐️ Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu! www.science.org/doi/10.1126/...

“They’re going to bring back suffering and death,” said Dr. Sean O’Leary, chair of the infectious disease committee for the American Academy of Pediatrics. “I don’t say that with any hyperbole, that’s exactly what’s going to happen.”

Hi @physgal.bsky.social! We are a university account that often posts physics news, and we'd be interested in joining the Physics and Science feeds! Here are some of our articles: www.cmu.edu/mcs/news-eve... www.cmu.edu/mcs/news-eve...

Excellent tutorial by @jakescottmd.bsky.social substack.com/inbox/post/1...

Happy Christmas to all my university colleagues. www.nature.com/articles/d41...

The "Szilard Point." When we talk about The strain and the drain on scientific publishing, it's this. Researchers are working more just to stay afloat, and less on what we actually want them to do: research, discover, innovate. Strain: direct.mit.edu/qss/article/... Drain: arxiv.org/abs/2511.04820

#BBCNews - Drones detect deadly virus in Arctic whales' breath www.bbc.co.uk/news/article...

“The ‘early ideation stages’, when worlds are being fleshed out by writers and artists, are literally crucial to the development of a game’s vision,” stressed Canavan. “This is what concept artists were made for. Why would you pollute that glorious creative movement with joyless, photocopied art?”

Do viruses use RNA to rewire bacteria? Yes! In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection. #RNA #Phage doi.org/10.1016/j.mo...

As far as I can tell, RFK Jr.'s latest antivax stunt runs counter to the WMA Declaration of Helsinki. Withholding HepB vaccination clearly does not meet any definition of clinical equipoise. Doing it anyway, overseas, is straight up colonialist medicine. Details in Dr. Jacobs's thread below.

We present an end-to-end differentiable Bayesian framework for learning the latent parameters of coarse-grained potentials for IDPs. By optimizing a likelihood objective via importance-weighted gradients, we align generative protein ensembles with experimental observables doi.org/10.1529/biop...

More about RFK Jr.'s colonialist medicine. The study team describes period before universal vaccination-at-birth in 2027 as a "unique window of opportunity". In a sense they're right. It's a unique window of opportunity for a wealthy country to experiment on citizens of the global south.

Are you interested in integrative structural biology, but feel a bit lost? Don't worry, we have you covered with our FEBS Advanced Course, Lost in Integration Vol. 2 — probing biomolecules with AI and experiments probingbiomolecules2026.febsevents.org network.febs.org/posts/integr...

"officials describe [the NIH Director] as a largely ineffectual figurehead, often absent from leadership meetings...fixated more on cultivating his media image...Memoli, by contrast, knows just enough about the agency to help destroy it" www.theatlantic.com/health/2025/...

I am not an historian, but *anyone* who has ever been in Rome would have noticed a gigantic white building (see behind gladiator in the image) known as "altare della patria", which is about 120 year old, i.e. *yesterday* in Roman timescales...