@stapleslab.bsky.social
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📥 241
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reposted by
Aga Gambus
16 days ago
Last 3 days to apply for this post. Deadline 27/10/25
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New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
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A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...
https://www.biorxiv.org/content/10.1101/2025.10.22.683685v1
18 days ago
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reposted by
Alessandro Costa
4 months ago
Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
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Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
https://crick.wd3.myworkdayjobs.com/External/job/London/Postdoctoral-Fellow---Costa-Lab_R2283-2
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reposted by
Unterholzner Lab
7 months ago
Pre-print alert! Together with
@stapleslab.bsky.social
and
@cejkalab.bsky.social
we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. 👇👇
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New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with
@unterholznerlab.bsky.social
and
@cejkalab.bsky.social
www.biorxiv.org/content/10.1...
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IFI16 senses and protects stalled replication forks
Replication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...
https://www.biorxiv.org/content/10.1101/2025.04.07.646548v1
7 months ago
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reposted by
Petr Cejka
8 months ago
Check out our review on DNA end resection! With Raphael Ceccaldi,
www.nature.com/articles/s41...
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Pls repost. Postdoc role on post-replicative ssDNA gap processing. Interesting models that should float replication aficionados boats. DM or
[email protected]
for info. Until Dec26 but will strive for funding to provide continuity. Fantastic place to live+work
www.jobs.ac.uk/job/DMG682/r...
8 months ago
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Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email
[email protected]
for info
8 months ago
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