@nadeemshaikh.bsky.social
š¤ 93
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š 23
Staff Scientist, Barts Cancer Institute QMUL
Deadline is very soon (12pm November 5th) so get those applications in for a PhD position at Barts Cancer Institute working on radiotherapy resistance , copy number alterations and chromosomal instability !
add a skeleton here at some point
7 days ago
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Itās time for academics and academic institutions to do the right thing
www.soas.ac.uk/about/news/s...
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Senate statement on Gaza, Palestine
The Senate has published aĀ āSenate Statement on Scholasticide in Gaza, Palestineā.
https://www.soas.ac.uk/about/news/senate-statement-gaza-palestine
9 days ago
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reposted by
Iva ToliÄ
20 days ago
Two back-to-back stories on mitosis led by my incredible postdoc
@krunovuk.bsky.social
at
@institutrb.bsky.social
, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in
@natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
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reposted by
Eva Petermann
20 days ago
A follow-up PhD project is now available:
www.findaphd.com/phds/project...
add a skeleton here at some point
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reposted by
Dr Tanya Soliman
about 1 month ago
Are you a future black leader in cancer? Come join
@mirazrahman.bsky.social
and my labs
@qmbci.bsky.social
@kingscollegelondon.bsky.social
to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details
www.colcc.ac.uk/2026-blic-ph...
add a skeleton here at some point
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Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!
add a skeleton here at some point
about 1 month ago
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Ultimate dream - scientific work leading to major impact on peopleās lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease
www.bbc.co.uk/news/article...
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Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
https://www.bbc.co.uk/news/articles/cevz13xkxpro
about 2 months ago
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reposted by
Eric Joyce
about 2 months ago
Weāre excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, weāre piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
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Oligopaint Probe Requests
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff membā¦
https://ericjoycelab.com/oligopaint-fish-probe-requests/
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@mcclellandlab.bsky.social
hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with
@mollyguscott.bsky.social
& I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
about 2 months ago
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About time academics showed some moral fibre
www.uu.nl/en/news/utre...
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Utrecht University will not enter into any new collaborations with Israeli organizations until further notice
Utrecht University has decided to suspend all new collaborations with Israeli organizations until a committee can provide guidance on potential partners.
https://www.uu.nl/en/news/utrecht-university-will-not-enter-into-any-new-collaborations-with-israeli-organizations-until
2 months ago
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Ever more depraved , like real world Squid Games, they should be relegated to pariah status
www.bbc.co.uk/news/article...
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Gaza aid site offered a 'women only' day. It didn't stop the killing
Families say mothers Mary Sheikh al-Eid and Khadija Abu Anza were shot while seeking aid from GHF station in southern Gaza.
https://www.bbc.co.uk/news/articles/c74z4gy5g31o
4 months ago
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reposted by
Iain Cheeseman
4 months ago
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
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Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
https://www.biorxiv.org/content/10.1101/2025.07.22.666109v1
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reposted by
Eva Petermann
4 months ago
We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene.
www.nature.com/articles/s41...
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Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene
Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress
https://www.nature.com/articles/s41388-025-03489-8
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Itās starting š 12 children, 21 adults starved to death by Israel.
www.bbc.co.uk/news/article...
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Gaza health ministry says 33 people died from malnutrition in 48 hours
Fifteen deaths have been reported over the past day, the Hamas-run ministry says, as the UN warns of
https://www.bbc.co.uk/news/articles/cq8zlx8xwjno
4 months ago
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Great talk by
@susanagodinho.bsky.social
at London Cell Club today
4 months ago
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Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug
www.bbc.co.uk/news/article...
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Gaza officials say children killed in strike as Israeli military admits 'error'
Six children waiting for water are among those killed in an Israeli air strike, emergency service officials say.
https://www.bbc.co.uk/news/articles/c0rvxjnvv71o
4 months ago
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reposted by
Alexander Stein
5 months ago
Interested in population genetics of cancer? If so, have a look at our manuscript accepted by
@genetics-gsa.bsky.social
, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
add a skeleton here at some point
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reposted by
JStark lab
6 months ago
We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience
www.cell.com/iscience/ful...
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Distinct functions of PAXX and MRI during chromosomal end joining
A key step of Canonical-Nonhomologous End Joining is synapsis of DNA double strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this pr...
https://www.cell.com/iscience/fulltext/S2589-0042%2825%2900983-6
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reposted by
Andreas Panagopoulos
6 months ago
Delighted to share that the results of my main postdoc project are now published in
@nature.com
š
doi.org/10.1038/s415...
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Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
https://doi.org/10.1038/s41586-025-08986-0
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reposted by
6 months ago
Hi all, my team
institut-curie.org/team/fachine...
@institutcurie.bsky.social
is looking for a Bioinformatician. You can find more details about the position here:
euraxess.ec.europa.eu/jobs/344508
Is anyone looking for a job in the lovely Paris?
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www.theguardian.com/commentisfre...
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A moment of judgment has come at last: not just for Netanyahu but for his enablers | Owen Jones
Israelās renewed assault on Gaza has prompted international condemnation, but many of those critics will face their own reckoning, says Guardian columnist Owen Jones
https://www.theguardian.com/commentisfree/2025/may/20/judgment-israel-gaza-benjamin-netanyahu-enablers
6 months ago
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reposted by
Barts Cancer Institute (Queen Mary University of London)
6 months ago
š° New research shows women of African and South Asian ancestry tend to develop and die of breast cancer at a younger age. š„ Prof Claude Chelala at BCI
@qmul.ac.uk
discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances. š§Ŗ
#medsky
#oncosky
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reposted by
Cold War Steve
6 months ago
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reposted by
The Guardian
6 months ago
If you were shocked by my film on Israeli settlers in the West Bank, you havenāt been paying attention | Louis Theroux
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If you were shocked by my film on Israeli settlers in the West Bank, you havenāt been paying attention | Louis Theroux
The response to The Settlers has been humbling. But the ongoing displacement and intimidation of Palestinians is more severe than we could capture, says documentary presenter Louis Theroux
https://www.theguardian.com/commentisfree/2025/may/10/louis-theroux-documentary-on-israeli-settlers-in-the-west-bank?utm_term=Autofeed&CMP=bsky_gu&utm_medium=&utm_source=Bluesky#Echobox=1746855513
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reposted by
Financial Times
6 months ago
Opinion from the FT's Editorial Board: 'The US and European countries that tout Israel as an ally that shares their values have issued barely a word of condemnation. They should be ashamed of their silence, and stop enabling Netanyahu to act with impunity.'
www.ft.com/content/f5fd...
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reposted by
Michelle Lockley
6 months ago
Can we use the power of evolution to improve ovarian cancer treatment? Our latest paper says yes! Online now at Cancer Research. Thanks to
@trevorgraham.bsky.social
coauthors and
@cancerresearchuk.org
for funding.
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reposted by
Barbara Marte
7 months ago
this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.
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reposted by
Veronica Rendo
8 months ago
š£ Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification.
www.cell.com/cell-genomic...
š§µš:
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Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala etĀ al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00071-0
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Fifteen ambulance staff slaughtered and then hidden in mass grave by Israeli army.
www.bbc.co.uk/news/article...
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Survivor challenges Israeli account of attack on Gaza ambulances
Palestinian paramedic Munther Abed rejects Israel's assertion that the vehicles approached troops with their lights off.
https://www.bbc.co.uk/news/articles/ckgere1y740o
7 months ago
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reposted by
DeBerardinis Lab at UT Southwestern Medical Center
8 months ago
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and
@cri-utsw.bsky.social
www.science.org/doi/10.1126/...
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
https://www.science.org/doi/10.1126/sciadv.adt1241?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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reposted by
Prem Thakker ć
8 months ago
BREAKING: Yuval Abraham, co-director of Oscar-winning documentary "No Other Land," says Israeli settlers beat his co-director Hamdan Ballal, injuring his head and stomach ā and then Israeli soldiers invaded the ambulance he was in and seized him. Ballal's whereabouts are now unknown.
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reposted by
Krishnan Guru-Murthy
8 months ago
Yesterday David Lammy was unequivocal that Israel is breaking international law. Today No 10 contradicts that and says it is merely āat risk of breachingā the law. It is an extraordinary position to put the Foreign Secretary in - who will now have to say why he was wrong, or why No 10 is wrong.
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reposted by
Middle East Eye (Unofficial)
8 months ago
Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025 -
https://www.middleeasteye.net/live-blog/live-blog-update/nearly-100-palestinians-killed-west-bank-israeli-attacks-2025
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Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025
<span class="field field-title">Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025</span> <span class="field field-uid"><a title="View user profile." href="https://www.middleeasteye.net/users/bilge-kotan" lang about="https://www.middleeasteye.net/users/bilge-kotan" typeof="schema:Person" property="schema:name" datatype>Bilge Kotan</a></span> <span class="field field-created"><time datetime="2025-03-10T11:12:12+00:00" title="10 March 2025 11:12 GMT">Mon, 03/10/2025 - 11:12</time> </span> <div class="field field-field-text"><p>At least 97 Palestinians were killed by the Israeli army and settler attacks this year, according to the Palestinian health ministry.</p> <p>The ministry said that the figure includes 16 minors and three women.</p> </div>
https://www.middleeasteye.net/live-blog/live-blog-update/nearly-100-palestinians-killed-west-bank-israeli-attacks-2025
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reposted by
Trevor Graham
8 months ago
We have an opening in our
#DataScience
core
@icr.ac.uk
. The post will work on a breadth of topics across
#cancer
biology, but expertise in spatial data, single cell and data integration are priorities. Details here:
jobs.icr.ac.uk/vacancies/11...
@jobrxiv.bsky.social
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Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...
https://jobs.icr.ac.uk/vacancies/1159/data-scientist.html
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reposted by
Mcclelland lab
8 months ago
Happy to post our first preprint in a while!
www.biorxiv.org/content/10.1...
. This was a slightly new direction for us, spearheaded by amazing post-doc
@audreylumeau.bsky.social
. Short thread to follow š§¬
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reposted by
bioRxiv Cancer Bio
8 months ago
High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing
https://www.biorxiv.org/content/10.1101/2025.02.27.640046v1
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reposted by
Show Israeli Genocide the Red Card
9 months ago
Hibs fans yesterday showed Israeli Genocide the Red Card šš„šµšø
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reposted by
9 months ago
We have another PhD project at
@qmbci.bsky.social
, within
@cruk-cityoflondon.bsky.social
RadNET, to understand how POLE3 promotes Double Strand Break repair and resistance to radiotherapy ! get in touch if you are interested in a PhD in genome stability !
crukradnet.colcc.ac.uk/phd-students...
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Investigating the role of POLE3 in resistance to ionizing radiation treatment - CRUK RadNet
Investigating the role of POLE3 in resistance to ionizing radiation treatment Primary supervisor: Roberto Bellelli, Queen Mary University of London Secondary supervisor:Ā Graeme Hewitt, Kingās College ...
https://crukradnet.colcc.ac.uk/phd-studentships/investigating-the-role-of-pole3-in-resistance-to-ionizing-radiation-treatment/
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reposted by
Soni Lacefield
9 months ago
Check out our super cool paper on aneuploidy in cells lacking Bub3. Congratulations to fantastic student Pallavi Gadgil and alum Olivia Ballew.
journals.plos.org/plosgenetics...
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Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3
Author summary Accurate chromosome segregation is crucial for the proper development of all living organisms. Errors in chromosome segregation can lead to aneuploidy, characterized by an abnormal numb...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011576
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reposted by
The EMBO Journal
9 months ago
Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals cancer adaptive strategies for alleviating aneuploidy consequences ā including increased expression of DNA replication & repair factors & of FOXM1 targets Zuzana Storchova and coworkers
www.embopress.org/doi/full/10....
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www.theguardian.com/world/2025/f...
Ethnic cleansing, one village at a time
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āLast nail in the coffinā: Israeli settlers push on with fresh West Bank land grab
There are fears that a widely unnoticed displacement of Bedouin has the aim of fragmenting the territory intended for a future Palestinian state
https://www.theguardian.com/world/2025/feb/13/last-nail-in-the-coffin-israeli-settlers-push-on-with-fresh-west-bank-land-grab
9 months ago
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reposted by
Andrew Feinstein
9 months ago
It pains me to say this as the son of a Holocaust survivor who has lectured on genocide prevention at Auschwitz where my mom lost dozens of her family, but Israel is seeking ālebensraumā to create a Greater Israel & is using genocide & ethnic cleansing to do so with the active support of the West š¢
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reposted by
Trevor Graham
9 months ago
Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out:
gut.bmj.com/content/earl...
The initial reaction from patients&families has been overwhelming Led by Ibrahim AlBakir
@yosoykit.bsky.social
@cancerresearchuk.org
@icrlondon.bsky.social
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Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...
https://gut.bmj.com/content/early/2025/01/29/gutjnl-2024-333353
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www.reddit.com/r/MapPorn/s/...
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From the MapPorn community on Reddit: Google Earth has begun updating images of Gaza
Explore this post and more from the MapPorn community
https://www.reddit.com/r/MapPorn/s/D1UkO2c97k
10 months ago
0
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reposted by
Lovorka StojiÄ
10 months ago
š¢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated.
#lncRNA
#RBP
#Mitosis
www.biorxiv.org/content/10.1...
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The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...
https://www.biorxiv.org/content/10.1101/2025.01.21.634161v1
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reposted by
Cantorlab
10 months ago
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity!
rdcu.be/d60Td
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Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
https://rdcu.be/d60Td
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reposted by
Geoff Macintyre
10 months ago
We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January!
www.cnio.es/en/empleo/re...
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reposted by
Owen Jones
10 months ago
If the Western media had told the truth, Israel's genocide would have been stopped a long time ago. They must be held to account for one of the worst crimes of our age. New post š
www.owenjones.news/p/western-jo...
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Western journalists must be held to account for complicity in genocide
Palestinian journalists risked their lives to tell the world the truth about Israel's genocide - and were treated like dirt by their Western colleagues.
https://www.owenjones.news/p/western-journalists-must-be-held
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reposted by
Tony Cesare
10 months ago
1/Delighted to announce the newest paper from our lab, āHomologous recombination promotes non-immunogenic mitotic cell death upon DNA damageā, is out today in
@naturecellbiology.bsky.social
,
www.nature.com/articles/s41...
.
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Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
https://www.nature.com/articles/s41556-024-01557-x
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reposted by
10 months ago
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41...
. Great work from
@sol-herve.bsky.social
& Andrea Scelfo in close collaboration with
@katemiro.bsky.social
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
HervƩ, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
https://www.nature.com/articles/s41556-024-01565-x
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