We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. www.biorxiv.org/content/10.1...

Dr. Randi Isenhart has a new 1st author publication for her work in the @ericjoyce.bsky.social lab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/jour...

ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @epsteind.bsky.social, @ericjoyce.bsky.social (@penngenetics.bsky.social), Arian Arab, @melikel.bsky.social (@pennepigenetics.bsky.social) & @SHugelier (@UPennPhysiology) @MolecularCell www.cell.com/molecular-ce...

two excellent papers on enhancer-promoter distance. Revisiting a classic unsolved problem. www.cell.com/molecular-ce... www.cell.com/molecular-ce... Wysocka and @chribue.bsky.social labs

🚀 Excited to share that my postdoc work with @adernburg.bsky.social on a Piezo-dependent meiotic checkpoint in C. elegans has just been published in Science doi.org/10.1126/scie... Here's a summary thread, or a “Skydive” (coined by @harmitmalik.bsky.social‬), of the key findings in this work 🧵⬇️1/10

Very happy to see this collaborative work with Eric Joyce and Doug Epstein labs out in press. Happy to have contributed our small part. Congratulations to Jailynn, who recently joined my lab as a postdoc, and all co-authors on this tour de force!

Our study with @ericjoyce.bsky.social led by Jailynn Harke is out. We show that allelic configurations at the Shh locus are predominately compact in the mouse forebrain, and that long range E-P interactions rely on transcription dependent and independent mechanisms. www.cell.com/molecular-ce...