Zachary Gardner in the Jain lab defends his thesis tomorrow!

Students✨ Alumni🎓 Faculty🧪 - Are you registered?! BGS is celebrating 40 years this fall🍂. Everyone who plans to attend should register in advance. For more info and to see who's coming: www.med.upenn.edu/bgs-at-40/

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...

Krista Budinich in the Liling Wan Lab has a recent preprint: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription pubmed.ncbi.nlm.nih.gov/40766627/

Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion ft. Joanne Thorvaldsen, Aimee Juan, Yemin Lan, Christopher Krapp & @marisa-bartolomei.bsky.social (@PennCDB/ @pennepigenetics.bsky.social) @PLOSGenetics journals.plos.org/plosgenetics...

Dr. Yeqiao Zhou, alum from the Faryabi lab (@faryabi.bsky.social), has a preprint publication on: OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments www.biorxiv.org/content/10.1...

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

📢 TODAY, September 11th, beginning at 10am, join us in the Smilow Lobby for Cores Day 2025 to learn more about the many outstanding biomedical research resources & services available across @pennmedicine.bsky.social, @chopresearch.bsky.social, @PennVet & @TheWistar! tinyurl.com/yc83cmj4

Please repost! We are looking for a new research specialist for our lab. See korblab.com for more about what we do and apply at wd1.myworkdaysite.com/en-US/recrui...

My great pleasure to introduce DR. Aoife O’Farrell!! An incredible scientist and human being. @aofarrell.bsky.social not only produced an amazing thesis by her own sheer brilliance and will, but also provided tireless service to Penn Bioengineering. Will be sorely missed!

#ICYMI: Registration is now open for Cores Day on Thursday, September 11th!🥳🎉 @pennmedicine.bsky.social @chopresearch.bsky.social @PennVet ‪@wistar.org -Free registration➡️ tinyurl.com/3bu5pjfd -Event website➡️ tinyurl.com/yc83cmj4

Amy Gladstein in the Feldser lab defends her thesis tomorrow!

New from the lab led by @natrigg.bsky.social. We started by characterizing mRNA in sperm, EVs, and the epithelium across epididymal transit. This revealed evidence that sperm acquire specific mRNAs through fusion with epididymal EVs, which we further established with in vitro co-incubation assays

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. www.biorxiv.org/content/10.1...

Complex genetic variation in nearly complete human genomes ft. @glennislogsdon.bsky.social (@penngenetics.bsky.social / @pennepigenetics.bsky.social) @nature.com www.nature.com/articles/s41...

📣 New publication from our group! 📣 Our work showing that the leukemia mutated genes PHF6 and PHIP act as a chromatin complex to repress AML stemness is now out in @genesdev.bsky.social. Congratulations to first author @aishwarya2510.bsky.social, who defended her PhD on this work this month!

📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26! Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico. Speakers, details & registration➡️ bit.ly/46JQbze

Kaitlyn Shen in the Jain lab defends her thesis tomorrow!

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues ft. Pengfei Guo, @LiranMao, Chin Lee, Xiaowei Xu, @dengyanxiang.bsky.social (@pennpathlabmed.bsky.social), Yufan Chen, Angelysia Cardilla, Dengge Jin & Yucong Hua (@PennEngineers) www.nature.com/articles/s41...

So excited that Sean Louzon is defending his thesis this Friday!! Come to hear about his exceptional work on the histone variant H2BE in astrocytes and in aging brains.

Congratulations to @LilingWanLab (@penncbio.bsky.social/ @penncancer.bsky.social), recipient of a 2025 @PershingSqFdn Sohn Cancer Prize! tinyurl.com/zse5mbj4

Very excited to share our new work on gastruloids by the incredible Cat Triandafillou! We mapped gene expression across 26 individual gastruloids at single-cell resolution and discovered some pretty amazing patterns about how these "mini-embryos" organize themselves. www.biorxiv.org/content/10.1...

[0/8] Stoked to share our work with @arjunraj.bsky.social on tissue organization in the gastruloid. We use lineage tracing and spatial transcriptomics to show that diversity among stem cell clones promotes, rather than hinders, gastruloid development: www.biorxiv.org/content/10.1...

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

Dr. Randi Isenhart has a new 1st author publication for her work in the @ericjoyce.bsky.social lab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/jour...

Neuropeptides & the division of labor ft. M. Gilbert, K. Glastad, @maxxfioriti.bsky.social, M. Sorek, T. Scarpa, F. Purnell, D. Xu, J. Baeza, R. Lauman, @BalintZKacsoh, R. Bonasio, B. Garcia & @berger_lab @pennepigenetics.bsky.social @penngenetics.bsky.social www.sciencedirect.com/science/arti...

🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...

Aishwarya Pawar (@aishwarya2510.bsky.social‬) in the ‪@paralkarlab.bsky.social defends her thesis tomorrow!

nph.onlinelibrary.wiley.com/doi/10.1111/... Very happy to share a new Tansley Review from my grad student Isabella Higgins (first first-author paper!) and postdoc Sarah Choudury on transcription factor functional divergence in plants and animals. We hope people find it useful! @newphyt.bsky.social

Join @BB_UPenn, @penncbio.bsky.social, @PennCDB, @CAMBUpenn, @UPennEEJust, @duboiscircle, @RTAatPennMed on Wednesday, 6/18 at 1pm for the 3rd annual #Juneteenth seminar ft'ing keynote speaker Dr. Squire Booker. Learn more➡️ tinyurl.com/kpnetx9f

Ashley Karnay (@AKarnay) in the Jain lab defends her thesis tomorrow!

A new publication for Keegan Krick in the Heller and Lynch labs on Meta-analysis of activated neurons reveals dynamic regulation of diverse classes of alternative splicing pubmed.ncbi.nlm.nih.gov/40274361/

🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Molecular basis of influenza ribonucleoprotein complex assembly & processive RNA synthesis ft. Ruchao Peng, Xin Xu, Yikang Gong, Fenglin Li, Max Ferretti, Mingyang Zhou, Kristen Lynch, @gburslem.bsky.social, @MarmorsteinLab & @yiweichang.bsky.social (@BB_Upenn) www.science.org/doi/10.1126/...

Method published by S Fallacaro in the @MirLab: Quantifying Transcription Factor Enrichment at Target Loci in Live Embryos pubmed.ncbi.nlm.nih.gov/40418447/

Nina Kuprasertkul (@NinaKupra) in the @briancapell and Wellen labs defends her thesis tomorrow!

Honored to receive Pershing Square Sohn Cancer Research Prize, which supports us to explore how cancer cells hijack abnormal protein condensates to rewire 3D genome. pershingsquarephilanthropies.org/prize-winner... @pennmedcso.bsky.social @penncancer.bsky.social @pennepigenetics.bsky.social

Penn Genetics is excited to host Harmit Malik who will be giving the Bernard Cohen Memorial Lecture today.

🎤 Postdocs: want to take the next step and become a #PI? Apply to speak at the TALENT FORUM @www.helmholtz-munich.de, showcase your research in Epigenetics & Nucleic Acids, and connect with top scientists. 🧳 Travel & accommodation covered if selected! 📝 Apply by 31July. 🔗 Info: lnkd.in/drkRvz7N

Celebrate our 2024-2025 graduates with us! www.med.upenn.edu/bgs/cell-and...

Intracellular protein editing & noncanonical residues in endogenous proteins ft. J. Beyer, K. Toy, M. Najar, N. Raniszewski, @gburslem.bsky.social (@BB_UPenn), @ysereb.bsky.social, @efeierman.bsky.social, @korblab & @ophirshalem.bsky.social (@penngenetics.bsky.social) www.science.org/doi/10.1126/...

Check out our (@natrigg.bsky.social and Grace Lee) protocol for determining the functions of sperm, and other, RNAs during early development. star-protocols.cell.com/protocols/4200

Our graduate student Marissa is graduating in a week!!! So excited for this and to see Marissa’s paper out soon… (stay tuned…)

Nicholas Aboreden (@ngaboreden) in the Blobel Lab defends his thesis tomorrow!

Congratulations to Shelley Berger (@PennCDB), recipient of the 2024 @theaacr.bsky.social-Women in Cancer Research Charlotte Friend Lectureship! @berger_lab @pennepigenetics.bsky.social @penncancer.bsky.social @PennSAS tinyurl.com/3t3a8zab

Congratulations to @glennislogsdon.bsky.social (@penngenetics.bsky.social/ @pennepigenetics.bsky.social) on being named a 2025 Searle Scholar! tinyurl.com/ma4sp577

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

New paper from Keegan Krick, in the Heller and Lynch labs on: Meta-analysis of activated neurons reveals dynamic regulation of diverse classes of alternative splicing pubmed.ncbi.nlm.nih.gov/40274361/