I would ask people to call or message their senators about this and specifically that Vinay Prasad needs to be out at FDA. Even the Wall Street Journal has said as much. There is push back. Companies won’t fund clinical trials if they can’t trust the FDA.

Once all of the other, uh, things are settled we really need a serious public health campaign around everything involved in being part of a society.

The people of Minnesota are feeding my soul with hope right now. It's been starving for even a crumb of inspiration, and they are serving up a hot buffet.

We are in business!!!!

Today, I told my students: We're working under pressures and constraints that aren't of our own making and that we have limited power to control. So, let’s not pretend that social forces stop at the classroom door. Instead, let’s take care of each other with empathy and support.

new level of science vendor dystopia: having to submit a webform to request a product's datasheet. It's annoying enough to do this with pricing. But datasheets? Absolutely not! 🧪

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

It's working better now, perhaps because it's 6pm EST 🤣

are we all trying to make our biosketches on SciENcv today or is the website just always this bad? 🧪

Our new bird feeder camera is up and the first images are in

Correlation or causation?

As a both a PI that received a Diversity Supplement to support a student on my R01, and a PO that reviewed them, they were never about "handing out money at the end of the year based on race" and always about the training potential and commitment.

Really important to stress that the Crown Jewels of the US higher education system were never the Ivies or elite SLACs (other countries have equivalents of these) but the well-funded, large, cheap, and excellently staffed public state university systems bringing high quality education to the masses.

Happy Pre-Thanksgiving weekend everyone! In the spirit of overindulgence I invite you all to feast on a cornucopia of Arey lab preprints (okay only two)! And fittingly their themes happen to be in the realm food and drink! Settle down next to the metaphorical fire as I share the stories...

Dear Admissions Committee, If only I could hand over the keys to my lab to them. I am sure they will achieve tenure before even taking their qualifying exam. My recent grant is based on their drunken doodle. *Recommendation letter not sent, no deadline included in email request.

Northern lights visible in the bay area!

Who wants to discuss innate immunity and host defense? Join us in Banff to share your exciting research. www.keystonesymposia.org/conferences/...

Incredible sunset for tonight's ferry commute

The sky is really putting on a show tonight

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

##caturday blep

You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office! There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB#ImpeachRFKand keep the momentum going! 🦆

Courage is contagious. Visibly fighting back empowers others to do the same

Send quack-o-grams to your congress members

PUT YOUR ACTIVISM SHOES ON

Especially important to read the fine print on who's paying for the flyers in your mailbox during contentious elections

💯this. The window for stopping the total destruction of US science is short - ask a scientist in Hungary. This is a time for bravery, resolve and action, not for putting your head down and “focusing on the science”. We need all hands on deck.

Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation! www.jbc.org/article/S002...

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

There is no common ground with those who don't see you as a full human being. You can't change minds but you can make their goals untenable. While the attention economy has rotted our collective brains, use it. Fight smarter and be vicious. There is no high road in hell.

Happy to get to contribute to this perspective in JEM!

Thank you @sophialiu.bsky.social, Margarida Saraiva, @cbartman.bsky.social, Nathalie Saurat, @pcrosato1.bsky.social, @licona-limonlab.bsky.social, @thepenkpanther.bsky.social, @guthmillerjenna.bsky.social, @coraline-mly.bsky.social, and @dremilygoldberg.bsky.social! rupress.org/jem/article/...

Firing and demoralizing feminized jobs as enemies of the state while brazenly bribing men with violent jobs that almost instantly puts them into the middle of middle class is very basic gendered warfare. Fulfilling the manosphere’s promise.

I had fun thinking about this and reading the advice from other women that I really respect! Thank you @jem.org for the opportunity. Find your people and do science with your friends

They recovered over 180 bullet shells at the CDC. Debris from shattered glass is still being cleaned up. I am completely stunned at how quickly the news cycle has moved on. This was an act of terrorism targeting public health experts, and the response seems to be a collective shrug.

I never went into academic science because I wanted to be wealthy—I fully knew the opposite is true. Instead I went into academic science because I have a lot of questions about how our cells work and I enjoy mentoring young scientists.

I’ve been having a few too many conversations like this. Them: Hi Kate, how are things with your work, with the world? Me: the university is under attack, democratic norms being broken in half, so, pretty bad. Them: But everything is going to come back and be okay after the midterms. Me: Uhh, no.

Many of us have long been worried about the harm of the 50% multiyear funding (MYF) requirement. When NCI published their payline at 4% AND cited MYF as the cause, I thought: “Someone in NCI is a hero. They took a huge risk to make the community aware.” www.cancer.gov/grants-train...

Happy #caturday

Spamming you with this knowledge of a tariff waiver for scientific instrumentation which you can apply for retroactively! bsky.app/profile/sara...

My heart just aches from all of this

The massive list of suspended UCLA grants came out today: 300 NSF and 500 NIH grants. I am miraculously not on the list, but this is devastating. Science will be lost, progress will be frozen, people will lose jobs, and careers in science and medicine are being destroyed. This is not ok.

Well well well

How's everyone coping tonight? Photo evidence and glib comments welcome

SCIENTIFIC RESEARCH SAVE LIVES: Last Thursday night, I was talking on the phone with my 87-year-old mother, and she had a SEIZURE WHILE ON THE PHONE! Rushed to the ER, had stroke symptoms that were reversed by a dose of the latest version of tissue plasminogen activator (clot-dissolving drug). 1/2

A small thing I learned from @booker.senate.gov's incredible filibuster is the importance of telling your stories to anyone who will listen. My senators aren't on this list but I'll email the members anyway 🧪

Given the lack of significant outrage, people are either unaware or believe they can weather this storm. The latter set reminds me of folks confident they would get on the lifeboats when the Titanic was sinking. At 5% success & a six-grant application limit, there aren't enough lifeboats. /2

I'm seeing lots of these stories and they ALL need to be sent to members of the appropriations committee. Many of these members have been asking good questions in hearings, and some GOP members have signaled clear support for NIH www.appropriations.senate.gov/about/members

The NIH was healthiest when pay lines were in the 20th percentile range. We are headed into an environment where pay lines are in the 5% range. In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one. This is going to destroy science.