Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

##caturday blep

You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office! There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB#ImpeachRFKand keep the momentum going! 🦆

Courage is contagious. Visibly fighting back empowers others to do the same

Send quack-o-grams to your congress members

PUT YOUR ACTIVISM SHOES ON

Especially important to read the fine print on who's paying for the flyers in your mailbox during contentious elections

💯this. The window for stopping the total destruction of US science is short - ask a scientist in Hungary. This is a time for bravery, resolve and action, not for putting your head down and “focusing on the science”. We need all hands on deck.

Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation! www.jbc.org/article/S002...

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

There is no common ground with those who don't see you as a full human being. You can't change minds but you can make their goals untenable. While the attention economy has rotted our collective brains, use it. Fight smarter and be vicious. There is no high road in hell.

Happy to get to contribute to this perspective in JEM!

Thank you @sophialiu.bsky.social, Margarida Saraiva, @cbartman.bsky.social, Nathalie Saurat, @pcrosato1.bsky.social, @licona-limonlab.bsky.social, @thepenkpanther.bsky.social, @guthmillerjenna.bsky.social, @coraline-mly.bsky.social, and @dremilygoldberg.bsky.social! rupress.org/jem/article/...

Firing and demoralizing feminized jobs as enemies of the state while brazenly bribing men with violent jobs that almost instantly puts them into the middle of middle class is very basic gendered warfare. Fulfilling the manosphere’s promise.

I had fun thinking about this and reading the advice from other women that I really respect! Thank you @jem.org for the opportunity. Find your people and do science with your friends

They recovered over 180 bullet shells at the CDC. Debris from shattered glass is still being cleaned up. I am completely stunned at how quickly the news cycle has moved on. This was an act of terrorism targeting public health experts, and the response seems to be a collective shrug.

I never went into academic science because I wanted to be wealthy—I fully knew the opposite is true. Instead I went into academic science because I have a lot of questions about how our cells work and I enjoy mentoring young scientists.

I’ve been having a few too many conversations like this. Them: Hi Kate, how are things with your work, with the world? Me: the university is under attack, democratic norms being broken in half, so, pretty bad. Them: But everything is going to come back and be okay after the midterms. Me: Uhh, no.

Many of us have long been worried about the harm of the 50% multiyear funding (MYF) requirement. When NCI published their payline at 4% AND cited MYF as the cause, I thought: “Someone in NCI is a hero. They took a huge risk to make the community aware.” www.cancer.gov/grants-train...

Happy #caturday

Spamming you with this knowledge of a tariff waiver for scientific instrumentation which you can apply for retroactively! bsky.app/profile/sara...

My heart just aches from all of this

The massive list of suspended UCLA grants came out today: 300 NSF and 500 NIH grants. I am miraculously not on the list, but this is devastating. Science will be lost, progress will be frozen, people will lose jobs, and careers in science and medicine are being destroyed. This is not ok.

Well well well

How's everyone coping tonight? Photo evidence and glib comments welcome

SCIENTIFIC RESEARCH SAVE LIVES: Last Thursday night, I was talking on the phone with my 87-year-old mother, and she had a SEIZURE WHILE ON THE PHONE! Rushed to the ER, had stroke symptoms that were reversed by a dose of the latest version of tissue plasminogen activator (clot-dissolving drug). 1/2

A small thing I learned from @booker.senate.gov's incredible filibuster is the importance of telling your stories to anyone who will listen. My senators aren't on this list but I'll email the members anyway 🧪

Given the lack of significant outrage, people are either unaware or believe they can weather this storm. The latter set reminds me of folks confident they would get on the lifeboats when the Titanic was sinking. At 5% success & a six-grant application limit, there aren't enough lifeboats. /2

I'm seeing lots of these stories and they ALL need to be sent to members of the appropriations committee. Many of these members have been asking good questions in hearings, and some GOP members have signaled clear support for NIH www.appropriations.senate.gov/about/members

The NIH was healthiest when pay lines were in the 20th percentile range. We are headed into an environment where pay lines are in the 5% range. In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one. This is going to destroy science.

1/ This is a long 🧵, so buckle up & I hope you read till the end. The HHS Secretary, is planning to remove all 16 members of the USPSTF the expert panel that decides which preventive services (cancer screenings, HIV prevention meds) must be covered by insurers under the Affordable Care Act.

Easy tips for science advocacy. If you're looking for something you can do, start here!

Everything seems real bad, so I’m reposting the good when I see it

Everyone repost this and share a positive science thing from your last week, month, etc. I had a great paper editing session with undergrad Tabitha on her 1st author paper. She's grown so much and now enjoys the narrative development in addition to her passion for the discovery and details.

I've been spiraling about the downfall of US science, but I am trying to focus on the kickass week our lab has had: 1. paper revision submitted 2. new paper out for review 3. postdoc fellowship submitted 4. grant submitted Finding hope and joy in science to renew my fighting spirit🧪👩‍🔬

Turner is ready for his #caturday debut How it started... how it's going.

Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now! "Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"

Super excited to share our newest story! We found that despite their well-known reliance on glucose, neutrophils also like lipids! Lipid uptake is induced by immune signals, and we think this is important in atherosclerosis and other lipotoxic metabolic diseases! www.biorxiv.org/content/10.1...

Really cool stuff! @dremilygoldberg.bsky.social @astratman.bsky.social @bbparis1984.bsky.social @balynzaro.bsky.social

Does everyone know there is a comment period re: changes in animal research at NIH? I didn't. Closes July 14. The scientific community need to respond en masse. I asked university leadership to distribute to reach our colleagues not on social media, you can too go.pardot.com/e/858023/duc...

terrible news! need the job to keep insurance, but the cuts come from the job. ♻️

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

Grateful to the American Diabetes Association @amdiabetesassn.bsky.social for the opportunity to make a short film about our lab at Stanford University. We talk about peptides and their roles in metabolic health. youtu.be/qUjYPTN09mI?... See you at ADA 2025 in Chicago

I would pick one topic that he is obviously advancing (for example, vaccines or fluoride), directly contrast his policy with data supporting the opposite policy (pithy, tho: numbers of studies, numbers of experts) and explicitly ask why he is choosing ideology over expertise in his policy making

Considering the Federal situation, campuses are encouraging labs to enter partnerships with industry. A plant breeding company reached out to see if my lab could rate their plant lines for their resistance to Ralstonia. I said "maybe, but these assays require personnel time and materials"

Please enjoy the tour of our new lab 🥹 Credit goes to our extremely resourceful PhD student

Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...

New paper identifying a cool new PTM, lysine sorbylation, that is... wait for it... CATALYZED BY HDACS! It's awesome seeing this mechanism active in different contexts.

This but for location sharing with docusign. NO. STOP!

Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab @aybv.bsky.social. I REFUSE to let this stop us!!!