Balyn Zaro
@balynzaro.bsky.social
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Assistant Professor @UCSF Chemical Biology, Mass Spec, and Innate Immunity
Is arginine the new cysteine?! Check out our lab's latest in collaboration with
@ianseiple.bsky.social
's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
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Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
https://www.biorxiv.org/content/10.64898/2026.01.05.697388v1
3 months ago
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reposted by
Balyn Zaro
Hani Goodarzi
10 months ago
Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...
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Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitati...
https://www.biorxiv.org/content/10.1101/2025.06.06.658309v1
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Excited to see this story finally out! What a fun and collaborative group to work with!
add a skeleton here at some point
11 months ago
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reposted by
Balyn Zaro
Vijay Ramani
about 1 year ago
Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (
@martyyang.bsky.social
) w/ huge assist from
@genophoria.bsky.social
lab. Lots to cover so let’s get this tweetorial started (1/n)!
www.biorxiv.org/content/10.1...
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Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers
We present a genome-scale method to map the single-molecule co-occupancy of structurally distinct nucleosomes, subnucleosomes, and other protein-DNA interactions via long-read high-resolution adenine ...
https://www.biorxiv.org/content/10.1101/2025.01.17.633622v1
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reposted by
Balyn Zaro
Vijay Ramani
about 1 year ago
Congrats
@willowcoyote.bsky.social
@amanglik.bsky.social
and all authors on a tour de force dissection of proton-sensing by GPCRs! DMS, cryo-EM, MD -- it has it all!
www.cell.com/cell/fulltex...
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Molecular basis of proton sensing by G protein-coupled receptors
Howard et al. combine mechanistic deep mutational scanning, cryo-EM, and constant-pH molecular dynamics simulations to provide a holistic view of proton activation in human pH-sensitive GPCRs.
https://www.cell.com/cell/fulltext/S0092-8674(24)01373-4
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