Balyn Zaro
@balynzaro.bsky.social
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Assistant Professor @UCSF Chemical Biology, Mass Spec, and Innate Immunity
Is arginine the new cysteine?! Check out our lab's latest in collaboration with
@ianseiple.bsky.social
's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
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Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
https://www.biorxiv.org/content/10.64898/2026.01.05.697388v1
22 days ago
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reposted by
Balyn Zaro
Hani Goodarzi
8 months ago
Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...
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Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitati...
https://www.biorxiv.org/content/10.1101/2025.06.06.658309v1
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Excited to see this story finally out! What a fun and collaborative group to work with!
add a skeleton here at some point
9 months ago
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reposted by
Balyn Zaro
Vijay Ramani
about 1 year ago
Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (
@martyyang.bsky.social
) w/ huge assist from
@genophoria.bsky.social
lab. Lots to cover so let’s get this tweetorial started (1/n)!
www.biorxiv.org/content/10.1...
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Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers
We present a genome-scale method to map the single-molecule co-occupancy of structurally distinct nucleosomes, subnucleosomes, and other protein-DNA interactions via long-read high-resolution adenine ...
https://www.biorxiv.org/content/10.1101/2025.01.17.633622v1
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reposted by
Balyn Zaro
Vijay Ramani
about 1 year ago
Congrats
@willowcoyote.bsky.social
@amanglik.bsky.social
and all authors on a tour de force dissection of proton-sensing by GPCRs! DMS, cryo-EM, MD -- it has it all!
www.cell.com/cell/fulltex...
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Molecular basis of proton sensing by G protein-coupled receptors
Howard et al. combine mechanistic deep mutational scanning, cryo-EM, and constant-pH molecular dynamics simulations to provide a holistic view of proton activation in human pH-sensitive GPCRs.
https://www.cell.com/cell/fulltext/S0092-8674(24)01373-4
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