How long until someone uses these to degrade BRD4?!

Congratulations to my great friend and colleague @bradylabupenn.bsky.social for this well deserved award! @pennmedcso.bsky.social @penncancer.bsky.social

Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation! www.jbc.org/article/S002...

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

New paper online at ACS Bio & Med Chem Au with @taabaman.bsky.social! New peptide probes and inhibitors for caspase 8 pubs.acs.org/doi/10.1021/...

I’ve been many times and always leave feeling this way!

Juneteenth is a story of freedom hard-won & resilience hard-kept—honoring Black history & the ongoing fight for justice. At Penn Medicine, Research Trainee Affairs advances discovery rooted in respect, access & opportunity—values that shape our comprehensive education, training & outreach mission.

Truly grateful and honored to have had the opportunity to share my work at the Bioorganic GRC and represent the Burslem lab 💙

Congratulations to @briehp.bsky.social who gave an awesome Knowles award talk at the Bioorganic GRC! Very proud PI!

Molecular basis of influenza ribonucleoprotein complex assembly & processive RNA synthesis ft. Ruchao Peng, Xin Xu, Yikang Gong, Fenglin Li, Max Ferretti, Mingyang Zhou, Kristen Lynch, @gburslem.bsky.social, @MarmorsteinLab & @yiweichang.bsky.social (@BB_Upenn) www.science.org/doi/10.1126/...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...

Intracellular protein editing & noncanonical residues in endogenous proteins ft. J. Beyer, K. Toy, M. Najar, N. Raniszewski, @gburslem.bsky.social (@BB_UPenn), @ysereb.bsky.social, @efeierman.bsky.social, @korblab & @ophirshalem.bsky.social (@penngenetics.bsky.social) www.science.org/doi/10.1126/...

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Honestly, if there is just one article that you are going to share far-and-wide today, it's this one: 'Trump Has Now Deported Multiple U.S. Citizen Children With Cancer' The headline says it all, and everyone needs to know about this. www.rollingstone.com/politics/pol...

Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!

Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach www.cell.com/molecular-ce...

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost. www.training.nih.gov/research-tra...

Excited to be co-chairing the Chemical tools to reveal new biology theme with @davidlabmsk.bsky.social!

I am sending so much love to my colleagues at NIH today. They are incredible people and scientists and don’t serve any of this. 💔

My favorite science is the kind that makes you says, "Man, I wish I thought of that!" This is such a paper. Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases. @dremilygoldberg.bsky.social @gburslem.bsky.social www.nature.com/articles/s41...

Non-canonical acylation of lysine residues catalyzed by HDACs! Congratulations to @dremilygoldberg.bsky.social for such beautiful work and thanks for bringing us along for the ride!

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

This will also help you find people outside your circle who are also fighting. Pick a cause you care about, find a group or event, and just show up. You'll realize you are not alone, not even close

I’ll be there. There is a war on science happening. I intend to fight back.

New paper online today! Check out @cewc9.bsky.socials review on how acetylation mediated protein degradation impacts cancer! Thanks for the invite to contribute to the 10th anniversary special issue of Trends in Cancer! www.sciencedirect.com/science/arti...

Two new preprints online today! One with @dremilygoldberg.bsky.social on lysine lactylation www.biorxiv.org/content/10.1... Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...

I'm excited to share our new preprint @biorxivpreprint.bsky.social describing what we think is the dominant mechanism of lysine lactylation. HDACs operating in reverse!! Great collab with @gburslem.bsky.social and @mzspectrum.bsky.social www.biorxiv.org/content/10.1...

We have a postdoc position available for a very cool collaborative project! Synthetic chemistry expertise is a must! Unfortunately due to the funding source, this position is only available to US citizens or permanent residents. chemistryjobs.acs.org/job/postdoct...

ft. Hana Odeh, Bo Lim Lee, @korrie_mack, Alice Ford, @eddiebarb, @Ryan_Cupo, @LaurenDrake0, @JennaNBeyer, @MohammadAltafN3, @gburslem.bsky.social & @ShorterLab (@BB_UPenn) @PGGUPenn @pennngg.bsky.social www.cell.com/cell-reports...

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.

Pennsylvanians, this would be Dave Sunday and link is here: www.attorneygeneral.gov

Worst week for science EVER. Sunday: ASM scrubs DEI mentions from website. Tue: NASA scrubs DEI from website; ICE arrests a student on campus; NSF plans to cut staff; USAID halted. Wed: HHMI kills diversity program; NIH trashes applications for diversity F grants. Fri: NIH cuts indirects.

I have run out of patience with the apparent silence of most US science institutions (and not just US) in the face of Trump & Musk's rampage. There are of so many facets of that, but in this column for @chemistryworld.com I talk about the assaults on inclusion. www.chemistryworld.com/opinion/scie...

Elon Musk is a terrible president.

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

That's one way to guarantee I'll never read your email....

US citizens or permanent residents from an under-represented group! You can contact any NIH-funded researcher you admire & suggest applying for this supplement to join their lab! High school thru postdoc/faculty. grants.nih.gov/grants/guide...

Ever wanted to edit a protein sequence inside a living mammalian cell? Maybe to site specifically incorporate a non-canonical residue? Perhaps you’d like to do a pull down without an antibody? Or use a small molecule fluorophore to image an endogenous protein? 1/4