Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award. @yiweichang.bsky.social

Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1 www.nature.com/articles/s41...

Thrilled to share that I’ll be joining the Perelman School of Medicine at the University of Pennsylvania! Our lab will be relocating to the Department of Pharmacology in Jan ’26. We’re hiring at all levels—reach out if you’re interested! @isbupenn.bsky.social @pennmedicine.bsky.social

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...

Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn

🔬 The 4th Structural Biology Symposium is almost here! Don’t miss out—there’s still time to register. bit.ly/4iM5QAm

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...

Registration is now open for the 4th Structural Biology Symposium. Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur... 🧬@Structuralbiology

Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.

Pharmacology 💊 women in STEM 👩🏻‍🔬 showed up & out for scientific funding! 🧬 #standupforscience2025 #standupforsciencephilly

Philadelphia Stand Up For Science! #standupforscience2025 Friday, March 7 · 11am - 1pm Philadelphia City Hall standupforscience2025.org

Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase" www.nature.com/articles/s41... #cryoEM #StructuralBiology

Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid" #cryoEM #TRPV2 #TRPchannels www.nature.com/articles/s41...

Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️ authors.elsevier.com/c/1kUW9L7PXq...