New research out in @natcomms.nature.com provides insight into the molecular mechanism of menthol-induced TRPV5 channel inhibition ft. José De Jesús-Pérez & Vera Moiseenkova-Bell (Systems Pharmacology & Translational Therapeutics) @isbupenn.bsky.social www.nature.com/articles/s41...

Congratulations to Nikolaos Sgourakis (@i3h-upenn.bsky.social), Mark Sellmyer (Radiology), @karanoelle.bsky.social (@penncancer.bsky.social) & @rdrapkin8-penn.bsky.social (OBGYN) on being named 2026 Early Detection Awardees! @themarkfdn.bsky.social @theaacr.bsky.social tinyurl.com/54pcj8dw

Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis ft. David Li, Rebecca Wells (@PennGIHep), Abigail Loneker, Jamie Ford (@pennengineering.bsky.social), Elaine Mihelc (@isbupenn.bsky.social) & Paul Janmey (Physiology) www.pnas.org/doi/10.1073/...

Congratulations to León Islas's and Vera Moiseenkova-Bell's lab members!!! Angélica Méndez-Reséndiz and José De Jesús-Pérez did amazing job on discovering how menthol inhibits TRPV5 channel. #cryoEM #TRPV #menthol #ColdSensation #ion #channels #calcium www.nature.com/articles/s41...

Join the Department of Biochemistry & Biophysics, the Johnson Foundation Biophysics & Structural Biology Core Facility, & the @isbupenn.bsky.social on 3/10 for their Symposium on Analytical Ultracentrifugation! Learn more & register➡️ tinyurl.com/47s2vnmf

Seeing mechanisms of disease Now online: “Seeing the mechanisms of disease with cryoEM” on Penn Medicine—how near-atomic views of molecules help us decode what goes wrong in illness. #cryoEM #SciComm www.pennmedicine.org/news/seeing-... @yiweichang.bsky.social @jrocereta.bsky.social

Freeze, image, cure Our cryoEM feature series is live on Penn Medicine: “Freeze, image, cure.” A closer look at how we visualize biology to understand disease and speed discovery. #cryoEM #ISB www.pennmedicine.org/news/freeze-...

Excited to share highlights of our recent discoveries by the Institute of Structural Biology at Penn Medicine. Made possible by our outstanding faculty, students, postdocs, and staff. www.pennmedicine.org/news/freeze-...

Wishing you & yours a restful & restorative holiday break! We'll see you back online in 2️⃣0️⃣2️⃣6️⃣! 💓✨

Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award. @yiweichang.bsky.social

Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1 www.nature.com/articles/s41...

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...

Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn

🔬 The 4th Structural Biology Symposium is almost here! Don’t miss out—there’s still time to register. bit.ly/4iM5QAm

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...

Registration is now open for the 4th Structural Biology Symposium. Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur... 🧬@Structuralbiology

Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.

Pharmacology 💊 women in STEM 👩🏻‍🔬 showed up & out for scientific funding! 🧬 #standupforscience2025 #standupforsciencephilly

Philadelphia Stand Up For Science! #standupforscience2025 Friday, March 7 · 11am - 1pm Philadelphia City Hall standupforscience2025.org

Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase" www.nature.com/articles/s41... #cryoEM #StructuralBiology

Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid" #cryoEM #TRPV2 #TRPchannels www.nature.com/articles/s41...

Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️ authors.elsevier.com/c/1kUW9L7PXq...