I am delighted to be among this years winners awards from the Biochemical Society! The Early Career Award recognises the work I did during my PhD and postdoc, and hopefully signals a bright start for my new lab within the @astbury-bsl.bsky.social at the University of Leeds 💫

Exciting to see momentum building around our concept of inverse agonist-bound GPCR–G protein complex structures (PMID: 39775170). Great work from the groups of Can Cao & Xiaoguang Lei: a clinically viable MRGPRX4 inverse agonist for chronic itch with therapeutic potential. Congrats to all!

Good fucking riddance. I am so relieved for my fellow Hungarians.

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

We’re delighted to welcome our newest lab member, Dr. Sayuri Pacheco! Fresh off her graduation at the Keck Medical School, she is joining us as a Postdoc. We’re excited to have her on board and looking forward to see the impactful research she’ll bring. @dornsife.usc.edu

Our NIAAA funded Post-DoctT32 has received its NoA (non competing renewal). Are you looking for a post-doc and interested in joining our amazing center? If so, reach out! Here is a convenient form that you can use to upload CV and a cover letter! unc.az1.qualtrics.com/jfe/form/SV_...

I have a new comment piece out in Nature today. rdcu.be/e7LVS 1/6

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code! There are multiple open positions! (1/3)

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.

The new ChimeraX CubeNTube plugin allows erasing parts of maps using cube, cylinder, and custom shapes and has undo. Created by Tamino Cairoli. Available from ChimeraX menu Tools / More Tools....

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements pubmed.ncbi.nlm.nih.gov/41711797/ #cryoem

Our study of the CAT1 amino acid transporter and viral receptor is now online in @natcomms.nature.com! Spearheaded by the incredibly talented @mingda-ye.bsky.social with colleagues from @cmd.ox.ac.uk, Strubi, CAMS Oxford Institute, @ndm.ox.ac.uk, and supported by the IM2PACT consortium.

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

Looking forward to #BPS2026 in San Francisco? Come by the NIH sponsored Transformative High-Resolution Cryo-Electron Microscopy National Centers for #CryoEM at booth 410. Our mission is to broaden access to high-resolution cryo-electron microscopy and tomography technologies - cryoemcenters.org

Fantastic news: our very own Aaliyah Tyson has been awarded a prestigious R36 NIDA Substance Use/Substance Use Disorder Dissertation Research Award. Many congratulations to this very well deserved recognition!

Are you a cell biologist who secretly thinks cellular cryo-electron tomography is just George Palade-era EM, but fancier? Join this webinar to see how modern #teamtomo has shifted from pretty pictures to quantitative, local membrane biology, and how that changes the questions we can ask.

Kicking off the new year with a completely refreshed look for the Filizola Lab website. Happy 2026, everyone! www.filizolalab.org

I’m excited to share that I’ve joined the Editorial Board of the Journal of Biological Chemistry. I look forward to serving this incredible community journal and engaging with exciting science! @asbmb.bsky.social 🧪

They grow up so fast! Huge congratulations to the newly minted Dr. Saif Khan, the first graduate of our lab. 🎓 He delivered a spectacular defense on our recent work in opioid receptor pharmacology. We’ll miss you greatly and wish you every success in your next chapter!

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

Come join our team! The deadline is December 7, but the application is quick. Only a cover letter, CV, and a short Research Highlight are needed #chemsky #chemjob #chembio

🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳 @microverse.bsky.social @lifeprofile.bsky.social rdcu.be/ePm4C

Structural snapshots capture nucleotide release at the μ-opioid receptor pubmed.ncbi.nlm.nih.gov/41193810/ #cryoem

Structural snapshots capture nucleotide release at the μ-opioid receptor

Great structure work about MOR binding states from the Cornelius Gati lab! Congrats to all the authors, particularly Saif Khan. Looking forward!

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

It was wonderful to return to UC Berkeley and deliver a lecture with Clayton Heathcock in the audience.

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Happy Halloween from the Janetzko lab 🎃 👻

In #ScienceSignaling, researchers describe the consequences of the removal of the switch III region from the critical G protein G-alpha-o and connect this defect to a severe neurological disorder in patients. https://scim.ag/4nxB7tc

Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

NCCAT's biennial SPA cryoEM shortcourse will be held in person on March 16-20, 2026 in NYC. Applications due December 15, 2025 and late applications due January 2, 2026: nccat.nysbc.org/activities/c... Hope to see you in NYC this spring!

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago

#CryoEM how do we feel about this instrument? We may be in the market and I want to know what people are currently using.

Excited to report the identification of small molecule inhibitors of OTOP1 and their binding sites. Congratulations to first authors Batuuji Burendei from Ward/Forli labs at TSRI and Josh Kaplan for great team work! rdcu.be/eMpV9

UGA is seeking a tenure-track Assistant Professor to develop an innovative research program focused on disease mechanisms. The ideal candidate will use cryo-EM and other structural techniques, with potential applications to future therapies. Apply here: www.ugajobsearch.com/postings/456...

Our home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! recruit.ap.uci.edu/JPF09887 Please apply and/or share this post.

🚀 Hey #GPCR community on #bluesky! 🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬 📅 Nov 12–14, 2025 This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR! #GPCRforum #ScienceTogether

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: [email protected]

OUT NOW! The Graduate School of Biomedical Sciences Dean's Report and message from Dean @martafilizola.bsky.social. Learn about the Graduate School at Mount Sinai's growth, innovation and achievement, and how they have excelled in 2025 👉 reports.mountsinai.org/article/grad...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

🚀 Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: www.biorxiv.org/content/10.1...