Shockingly disappointed in this impulse buy. So many simple chemistry mistakes… Love an easy read, and 100% support accessible science, but this is more frustrating than fun.

Keeping my identity secret requires two hotspots! Na-Na-Na-Na-Na-Na-Na-Na…

A new, small molecule inhibitor to NorA that increase fluoroquinolone efficacy against Staph. With everything: screening, med. chem., and CryoEM! doi.org/10.1101/2025...

Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!

We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: [email protected]

Exciting work from the Franklin, @ox.ac.uk, and @diamondlightsource.bsky.social has led to a new method for imaging small proteins (<50 kDa) using cryoEM. By using bifunctional, bispecific nanobody scaffolds, the team have successfully solved the smallest protein structure to date (14 kDa).

Di-Gembodies (dimerized nanobodies) for improved and duplexed CryoEM of small and challenging targets! A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social Out now in Nature Chemical Biology @natchembio.nature.com www.nature.com/articles/s41...

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k... (Please repost!)

Looking for a Post doc position in Structural Biology? We are hiring! See post here: jobbank.dk/job/2850337/... The task is to continue our endeavor in solving cryo-EM structures of the human dopamine transporter. See: doi.org/10.1038/s415... Thanks to the Novo Nordisk Foundation for funding.

Wow! Deep Mutational Scan of NaCT!! www.science.org/doi/10.1126/... Valuable to biochem. understand NaCT folding & function, and clinical VUS in SLC13A5-Epilepsy Beautiful study and Herculean effort by Wen-An Wang and REsolution colleagues in @supertifurgalab.bsky.social at @cemm.oeaw.ac.at

Closing soon! Please apply if you are interested in targeting membrane proteins with new therapeutics!

Unacceptable! 😡😡 Review deadline of 2 weeks, then cancel at 4 days as "time restrictions are too tight" "Paper [achieved] the required review" == editor knew this was waste of time I will always support colleagues by reviewing papers, but my view of your journal has changed.

Ugh. Account on Twitter is hacked. Still annoying, even if I'm not active there much these days.

Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving the landscape of Gi activation and how its modulated by different ligands! www.biorxiv.org/content/10.1...

Join our group in the Centre for Medicines Discovery at Oxford Univ. @cmd.ox.ac.uk @ox.ac.uk !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! my.corehr.com/pls/uoxrecru...

University bureaucracy (probably universal)

The 3rd NYC Integrative Structural Biology Symposium (#NYCISB25) will be Oct 9-10, 2025. Register today: nyc-isb25.eventbrite.com This event will be focused on integrative structural biological techniques and limited to 100 attendees.

@annaliiiiiiii.bsky.social got the cover of @cp-cellreports.bsky.social for her human muscle-type nAChR structure

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

2025 Spring Symposium lectures are now up on our YouTube channel: www.youtube.com/playlist?lis...

Today is SLC13A5 Epilepsy International Awareness Day, I'm reminded in an email this morning from Kim Nye, founder of TESS Research Foundation. Read more here: www.tessresearch.org/awareness/ and …

Hungry thanks to cinnamon rolls on the March issue of Nature Structural & Molecular Biology... Think I'll have a snack while reading about NaDC3 (@danengw.bsky.social), yeast CerS complex (@arnemoeller.bsky.social & @flofroehlich.bsky.social), and human CerS6 by our own @tomaspascoa.bsky.social

CCeMMP Seminar alert⏰ We welcome Professor Juan Du, Department of Molecular Biosciences, Northwestern University, Illinois, USA! “The importance of Physiological Temperature in Biomedical & Biophysical Research” More details and register: ccemmp.org/events/ccemm...

Fantastic visit to @astonaime.bsky.social today. Amazing work is happening here for membrane protein study and the development of purification technologies! Thank you @naomilpollock.bsky.social for the invite, and everyone at AIME for the fascinating conversations!!

Trying to do a bit of good in a recently stressful and chaotic world…

Dear al, check out our latest paper with @uhammes.bsky.social . A great collaborative effort by Lukas and Lam!!

First keynote of the day #bcium2025 from David Sauer @davidbsauer.bsky.social @diamondlightsource.bsky.social @ccpem.bsky.social @instruct-eric.bsky.social

View from the stage #bci-ccpem2025 @ccpem.bsky.social just about to start!

Mandatory online security training... with the video quality of a 1990s game cutscene. Nostalgia has me wanting a pack of Redvines and a dark room for hours of GDI vs NOD battles!

Fun little write-up of the SPNS2 collaboration :) Also, my first exercise with Blender and Molecular Nodes. Wow, does it make pretty pictures! Thanks for the YouTube tutorials @bradyajohnston.bsky.social. go.nature.com/41XuE25

*Deadline extended* Applications for this year's #CryoEM Data Processing Workshop are due March 27! Don't miss this chance to learn about various approaches to deal with conformational/compositional heterogeneity. myumi.ch/lsi-cryo-2025 @jbquerido.bsky.social @shyamalm.bsky.social

Join the program management team at Oxford's Centre for Medicines Discovery @cmd.ox.ac.uk !! my.corehr.com/pls/uoxrecru...

Someone in Ingelheim, Germany is also passionate about the Major Facilitator Superfamily!

Our preprint on atomistic modelling of the Campylobacter jejuni lipidome is out!

One more sleep to the @biophysicalsoc.bsky.social CRT Symposium on tomorrow morning bright and early! Join us in Petree Hall C at 8.30am.

Happy to have contributed to this excellent Methods in Molecular Biology chapter by Rhoderick Brown's lab, now in print. link.springer.com/protocol/10....

Can't wait to see you all at #BPS2025 for the #cryoem subgroup symposium! 8:30am-12:30pm, Sat Feb 15, Room 515B See detailed program at the link below. We have some superb science lined up, so please join us for what I hope will be a fantastic morning of science!

On this International Day of Women and Girls in Science, let's take a moment to remember Dorothy Crowfoot Hodgkin, winner of the 1964 Nobel Prize in Chemistry - at the time only the third woman to do so.

This is a fantastic meeting for the Cryo-EM community in the NYC area. This year it will take place on the East Coast of Manhattan. Please come and join us!

Okay, this is pretty cool! Functionalized nanobodies to modulate a channel’s activity

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

Saying farewell to the talented and incredibly productive Huanyu Li! We are very proud of your accomplishments at the @cmdoxford.bsky.social, and excited to see all you do in the future!

In a REsolution collaboration (part of RESOLUTE) we characterized 21 variants of hSLC39A8 (ZIP8), a key metal transporter. Our study reveals diverse impacts on localization, ion uptake & stability—shedding light on disease mechanisms. www.life-science-alliance.org/content/8/4/...

Fantastic work capturing the conformational states of ABCB1 from the Alam lab!

Some exciting news, folks. @timcoulson.bsky.social and I have a new science podcast launching soon. Please do follow the account for updates. More details coming very soon!

Biophysicists heading to #BPS2025 in LA and working in industry. I am looking for one or two more panelists for our industry panel on Tuesday Feb 18 1:00 - 2:30 pm. Than ks

📢 Registration is now open for the @diamondlightsource.bsky.social Biological Cryo-imaging User Meeting 2025! 📍Join us in Nottingham on April 23, in-person & online. Plus, don’t miss the CCP-EM Spring Symposium (April 24-25)🦠#CryoEM #BCIUM2025 🔗Register here: www.diamond.ac.uk/Home/Events/...

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others www.nature.com/articles/s41...