Comment period ends on Monday for a proposed rule change that would terminate student visas after 4 years. It also puts limits on exchange visitors and reps of foreign media, and shortens the length of time at the end of the visa from 60 days to 30 days. www.federalregister.gov/documents/20...

We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles. We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography zenodo.org/records/1717...

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...

Will you make it less tricky, and allow posting revised versions of preprints after peer-review? Sounds like an easy thing to do...

Come be my newest colleague! jobs.wisc.edu/jobs/assista...

Why is basic research important? Scientists struggled unsuccessfully for decades to develop an RSV vaccine. Then NIH scientists figured out the key structure of a protein. Now we have 3 vaccines and 3 monoclonal antibodies against RSV. www.scientificamerican.com/article/new-...

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons www.nature.com/articles/s41...

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists: urldefense.com/v3/__https:/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social

Rich Losick’s Farewell Publication Reexamines a Molecular Biology Milestone 🧪 🧬 #AcademicSky #higherEd www.mcb.harvard.edu/department/n... @cryptogenomicon.bsky.social @craigphunter.bsky.social @rachellegaudet.bsky.social @harvardmagazine.bsky.social @naoshigeuchida.bsky.social

𝗛𝗮𝗽𝗽𝘆 𝗧𝗲𝗮𝗰𝗵𝗲𝗿’𝘀 𝗗𝗮𝘆 𝘁𝗼 𝗮𝗹𝗹 𝘁𝗵𝗲 𝘁𝗲𝗮𝗰𝗵𝗲𝗿𝘀. 𝗜𝗻 𝗜𝗻𝗱𝗶𝗮, 𝗧𝗲𝗮𝗰𝗵𝗲𝗿’𝘀 𝗗𝗮𝘆 𝗶𝘀 𝗰𝗲𝗹𝗲𝗯𝗿𝗮𝘁𝗲𝗱 𝗼𝗻 𝟱𝘁𝗵 𝗦𝗲𝗽𝘁𝗲𝗺𝗯𝗲𝗿 𝗶𝗻 𝗿𝗲𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝗼𝗻 𝗼𝗳 𝗗𝗿. 𝗦𝗮𝗿𝘃𝗲𝗽𝗮𝗹𝗹𝗶 𝗥𝗮𝗱𝗵𝗮𝗸𝗿𝗶𝘀𝗵𝗻𝗮𝗻, 𝗮 𝗰𝗲𝗹𝗲𝗯𝗿𝗮𝘁𝗲𝗱 𝘁𝗲𝗮𝗰𝗵𝗲𝗿. 𝗧𝗲𝗮𝗰𝗵𝗲𝗿𝘀 𝗺𝗮𝗸𝗲 𝘂𝘀 𝘄𝗵𝗼 𝘄𝗲 𝗮𝗿𝗲 𝗮𝗻𝗱 𝗮𝗿𝗲 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁 𝗽𝗿𝗼𝗳𝗲𝘀𝘀𝗶𝗼𝗻𝗮𝗹𝘀 𝗶𝗺𝗵𝗼. 𝗟𝗲𝘁’𝘀 𝗴𝗶𝘃𝗲 𝘁𝗵𝗲𝗺 𝘁𝗵𝗲𝗶𝗿 𝗱𝘂𝗲 𝗿𝗲𝘀𝗽𝗲𝗰𝘁 𝗮𝗻𝗱 𝗿𝗲𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝗼𝗻.

Bluesky loves links — we don’t downrank or deprioritize posts with links in them, and as a result they get higher traffic, so lots of people post them.

Last day of Roles and Regulations of Protein Lipidation in Health and Disease meeting Soft condensed matter physics and complex aerodynamics never let name tags stay right side up. Solution ? Print on both sides! Also, thank you @biochemsoc.bsky.social for NO plastic covers. @GRC, taking notes ?

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

First session of the second day of Roles and Regulations of Protein Lipidation in Health and Disease meeting sponsored by @biochemsoc.bsky.social taught amazing insights into the role of protein palmitoylation in Parkinson’s Disease, Intellectual Disability and neurodegenerative disorders.

Not only are they stars of the NIH Intramural Program, they are global stars in their own areas. Congratulations Peng, Nirali and Ping. Proud to have you as colleagues. ccr.cancer.gov/news/article...

Thanks to Gareth Thomas and Vanessa Marensi for organizing the Roles and Regulations of Protein Lipidation in Health and Disease meeting at Exeter College, Oxford sponsored by the @biochemsoc.bsky.social Very much look forward to the next three days of scientific festivity.

Outstanding scientific session with impressive bodies of work that would make researchers at any stage of career, proud. Future of science is bright if we can nurture and encourage this young cohort of scientists. Let us do everything possible to make that happen. Congratulations to all awardees.

Inspirational talk by Ben Garcia @garcialabms.bsky.social at the @acs.org American Chemical Society National Meeting today. Thanks to @acsbiol.bsky.social ACS Biochemistry and Chemical Biology Division for sponsoring this session.

Molecule of the Month: Plastic-eating Enzymes pdb101.rcsb.org/motm/277

For the love of isoamyl acetate, please do it folks….

Last day at Cell Biology of Metals GRC on the University of Southern Maine campus. Like every year, I learned an amazing lot, made new friends with young and senior scientists and caught up with old friends I have been meeting and admiring thoughout my independent career. Look forward to 2027.

Here are the labs at the NIH Intramural Research Program- irp.nih.gov

Did you know that you can do your Ph.D. thesis research in anyone of the ~1100 labs in the NIH Inteamural Program ? Apply to the NIH-Graduate Partnership Programs that pairs NIH labs with universities. Get your degree from the university and choose from labs at the NIH for their research.

The fifth talk of the 5th Virtual ChemBioTalks will be given by @kellychibale.bsky.social. He will talk about “Mechanism of action studies of anticancer kinase inhibitors active against the human malaria parasite Plasmodium falciparum”. Make sure to register for free: https://cvent.me/G1geWW

Day 0 at the Cell Biology of Metals GRC. Always a fantastic time. Great education, great insights and lots of new ideas at the forefront of the field. Importantly a wonderful community. Look forward to the rest .

Thrilled to see NIHer Maxine Singer in the Yale University Women Scientists Hall of Fame

This is fascinating. @fromme-lab.bsky.social , perhaps of interest?

If you are the exhibit hall at @acastructuralsci.bsky.social #ACA2025 come by booth 35 to learn more about the NIH sponsored #cryoEM service centers that offer access to cryoEM technologies and training at not cost at the point of access. cryoemcenters.org

Also thrilled that Chris Fromme of @fromme-lab.bsky.social , my baymate during my Ph.D. is one of the co-chairs in 2029

Last day at the Molecular Membrane Biology Gordon Research Conference. My first time. I learned a ton. Great community, cutting edge science, fantastic support for trainees. Very much look forward to being back. Thanks to the organizers, Will Prinz, Gia Voeltz and Maya Schuldiner.

Folks, does anyone have experience using nanobodies as primary binders in Western ? If so, what do use for detection ? Any experience, positive or negative, would be much appreciated.

Fascinating.

This is wild! Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) www.nature.com/articles/s41... www.nature.com/articles/s41...

A thread on Juneteenth. Growing up in Arkansas in the 60s and 70s, I never heard a single word about it (although I'm sure that my black classmates had). I knew plenty of Civil War history, as one tended to, but I had no idea there was a specific day around Emancipation reaching Texas. (1/10)

LBNL will host a new supercomputer named after @jenniferdoudna.bsky.social 🎉 newscenter.lbl.gov/2025/05/29/d...

We still have an open postbac position in the intramural program of the NIH for starting sometime this summer. Shares, reposts much appreciated-

A new study from the #MacKinnonLab finds that many membrane proteins self-assemble into higher-order transient structures. These structures can explain a dynamic connectivity of components in membrane signaling pathways.

A new paper from the #MacKinnonLab in @pnas.org finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience

seen on the molecular biology transportation authority

Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks ! Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters. bit.ly/42jWXYD. /n

On #DNADay we celebrate the seminal 1944 discovery at Rockefeller by Avery, MacLeod, and McCarty that DNA, not protein, is the substance that carries genetic information. This *basic science* research opened the gateway to the modern era of the life sciences.

Many congratulations to @pallavisgadgil.bsky.social for being awarded the Lucille Smith award for excellence in Biochemistry. This award is in honor of the memory of Dr. Lucille Smith. The first woman at Dartmouth to attain the rank of full professor!

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

Family values and a positive mindset helped Geovanni Rodriguez advance his career from custodial staff to coordinating production for HHMI’s meetings and events.

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...

Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/... #mitochondria #cryo-EM