Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

www.nature.com/articles/s42... Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency @charlesmbrenner.bsky.social congratulations!

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei

Only good papers on mitophagy this week! biomed.news/bims-tofagi/... Highlights: -The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy -Piecemeal Mitochondrial degradation in plants -Allophagy?! Thanks to @biomednews.bsky.social

Metabolic Messengers: itaconate www.nature.com/articles/s42...

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia www.nature.com/articles/s42...

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "There are years that ask questions and years that answer."-Zora Neale Hurston

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...

Fantastic initiative!

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Required reading for cell biologists to get a sense of basic statistical principles! www.nature.com/articles/s41...

Mitophagy updates of last week 🪫🗑️ biomed.news/bims-tofagi/... Highlights: -two papers on the beneficial effects of mitophagy in CD8+ T cells -VPS35 mutations in PD affect PINK1/Parkin mitophagy selectively -review on selective autophagy initiation Thanks to @biomednews.bsky.social for pre-sorting

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology www.nature.com/articles/s42...

A baby with CPS1 deficiency, a world-first use of in vivo gene editing, and the emotional, ethical, and scientific questions that follow. In the latest Podcast, Kiran Musunuru, Rebecca Ahrens-Nicklas, and Julien Baruteau discuss. open.spotify.com/episode/3m2r...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Metabolic regulation of immunity in the tumor microenvironment www.cell.com/cell-reports...

A new collection of papers related to #mitochondrialdisease from #week44! 📚 💚 biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer www.nature.com/articles/s41...

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial www.nature.com/articles/s43...

A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics www.nature.com/articles/s41...

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease www.nature.com/articles/s42...

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

In this week's issue of mitophagy news 🗑️🪫 biomed.news/bims-tofagi/... -High sugar diet inhbits renal mitophagy and disrupts renal function -a review by @soleimanpourlab.bsky.social on mitophagy in diabetic ß-cells -Optineurin is necessary for mitochondrial removal during erythrocyte maturation

Happy Sunday!! Ready for a new spectacular issue of #cebooc?👇🏽 biomed.news/bims-cebooc/... Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo

Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚 "Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D

very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...

Been a rough year for federally funded scientists, and I hate to add another tab to this spreadsheet. So far, the shutdown has resulted in cancellation of 161 CSR study sections. 🧪https://docs.google.com/spreadsheets/d/1lLEx14q7HKrlYahQYJaN6aHKpMqSMJwX4aenyL5g_ZU/edit?usp=sharing

Our #genetics clinic is hosting a Metabolic Community Day on Saturday Oct 25 at Mason Mill Park for families navigating rare metabolic disorders. Special diets/formula/insurance -- lots to discuss and figure out together! #rarediseases

Gene therapy-mediated overexpression of wild-type MFN2 improves Charcot-Marie-Tooth disease type 2A www.biorxiv.org/content/10.1...

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

NIH Study Sections are on hold...again. drugmonkey.wordpress.com/2025/10/13/n...

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚 biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations www.science.org/doi/10.1126/...

Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading "To see takes time, like to have a friend takes time." -Georgia O'Keeffe

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

Acidosis orchestrates adaptations of energy metabolism in tumors www.science.org/doi/10.1126/...

Leveraging modern scientific tools and techniques, @ishahjain.bsky.social intends to transform our understanding of the critical roles that vitamins play in health and disease.

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

In this week's mitophagy news 🪫🗑️ biomed.news/bims-tofagi/... ⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡ -Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway Thanks to @biomednews.bsky.social

Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization. www.cmghjournal.org/article/S235... Wonder how metformin induced LacPhe (pmc.ncbi.nlm.nih.gov/articles/PMC...) affects macrophages and gut inflammation. @immunometforum.bsky.social

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria www.biorxiv.org/content/10.1...

D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport elifesciences.org/reviewed-pre...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging www.nature.com/articles/s43...