Debnath Ghosal (@debnathghosal.bsky.social)

A. baumannii is one of the most notorious multidrug-resistant pathogens, capable of forming drug-tolerant biofilms that make infections exceptionally difficult to treat. But how are these complex microbial fortresses built? Just published in Nat Comms. pubmed.ncbi.nlm.nih.gov/41654547/

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Antiparallel stacking of Csu pili drives Acinetobacter baumannii 3D biofilm assembly - PubMed Many Gram-negative nosocomial pathogens rely on adhesive filaments, known as archaic chaperone-usher pili, to establish stress- and drug-resistant, multi-layered biofilms. Here, we uncover the mechanism by which these pili build three-dimensional (3D) biofilm architectures. In situ analyses of Acine … https://pubmed.ncbi.nlm.nih.gov/41654547/