Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM https://www.biorxiv.org/content/10.64898/2026.01.14.699513v1

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! 🧪🧠Cell www.cell.com/cell/fulltex...

Oral 4′-fluorouridine rescues nonhuman primates from advanced Lassa fever rdcu.be/eYurU

Powerful piece in STAT this morning from some NIH staff members who have resigned www.statnews.com/2026/01/10/n... 1/3

Excited to share our latest research, out today in Cell (@cellpress.bsky.social) Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling. Read the paper here: doi.org/10.1016/j.ce...

Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

And congrats to the devs of an alternative method for measuring membrane thickness. Excited to see new tools expanding in parallel! #teamtomo is clearly more than structural biology, and quantitative cell bio is where it can shine! 🌞https://bsky.app/profile/deglushk.bsky.social/post/3m4x2nh73nc2e

#teamtomo gets another quantitative cell biology tool! We extend our Surface Morphometrics pipeline to measure membrane thickness. Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).

Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!

Online today, the journal version of our ( @nanigrotjahn.bsky.social @attychang.bsky.social @mmedina300kv.bsky.social) manuscript from earlier this year describing membrane thickness measurement in cells with #teamtomo! rupress.org/jcb/article/...

The role of kinase domain dimerization in EGFR activation pubmed.ncbi.nlm.nih.gov/41421344/ #cryoem

Interesting study showing how genetic variation can limit antibody therapies, led by the DBM team (Lepore & Jeker) with computational structural analysis from @torstenschwede.bsky.social @biozentrum.unibas.ch www.biozentrum.unibas.ch/news/detail/... #PrecisionMedicine #Genetics #AntibodyTherapy

BBC News - Drones detect deadly virus in Arctic whales' breath www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)

If you want to learn how to process cryo-ET data using the Chlamy dataset don't forget to check : tomoguide.github.io @phaips.vd.st

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12.09.693325v1 #cryoem

JOB ALERT: Operations Director (DCI–Lausanne). The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne. 📩 Questions: CEO of the DCI: @chgenoud.bsky.social 🔗 Apply here: careers.epfl.ch/job/Lausanne...

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion pubmed.ncbi.nlm.nih.gov/41402251/ #cryoem

@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.

In another inspiring talk at #EMBOComp3D, Julia Mahamid spoke about recent in-cell cryo-ET results www.biorxiv.org/content/10.1...

We deleted an earlier post because we regretfully mis-spelled Dr. Lim's name. Our apologies for this oversight.

エボラウイルスヌクレオキャプシドの細胞内での構造解析についての日本語の総説がでました。生物物理　Vol. 65 No. 6（通巻382号）ウイルスの構造やクライオ電顕を用いた細胞内での蛋白質解析に興味がある人は目を通していただけたら嬉しいです！https://www.biophys.jp/pub/pub01.html

Three German universities offering post-docs for researchers "who cannot conduct or continue their work in the USA appropriately because of actual political pressure. " www.uni-konstanz.de/zukunftskoll...

In situ structure of a gap junction-stomatin complex pubmed.ncbi.nlm.nih.gov/41191766/ #cryoem

Hey #TeamTomo 🧪🔬, ICECREAM is getting tastier! Please give it a try on your tomograms and send us feedback so we can get the recipe just right 🍦😋

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software. www.nature.com/naturecareer... Apply by 25 NOV #PostdocJobs #ScienceJobs

The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2

mRNA vaccines 🤝 designed nanoparticle immunogens

Opportunity in computational structural biology at ISTA (Vienna Austria) duration: 5 years with possibility of permanent contract #StructBiol #cryoEM #cryoET #chemsky 🧪 ista.ac.at/en/job/tenur...

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

今年のノーベル生理学、医学賞を受賞された、坂口先生のインタビューが見れます！おめでとうございます！🎉　www.osaka-u.ac.jp/ja/news/topi...

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪 careers.umass.edu/amherst/en-u...

This is a fucking tragedy www.cbc.ca/news/canada/...

⚠️ Half of commercial antibodies miss their target! So how do you pick the right one for your experiment? Here’s the solution 👉 Antibody characterization data (all tested in KO cells) are now available at: 🔗 onlygoodantibodies.co.uk Tested by @ycharos.bsky.social & @oga-community.bsky.social

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes | Nature Communications share.google/1S8f1xeAJa0E...

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.

One of our new manuscripts is now available on bioRxiv! Stay tuned!

Vaccination of frontline health workers and contacts of people infected with #Ebola has begun in the #DRC’s Kasai Province where an outbreak of the disease has been declared: www.afro.who.int/countries/de...

📢 Conduct your PhD thesis research at Janelia. 🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology. 🌐 Collaborate across disciplines 🛠️ Work with tool builders 🤝 Train in a supportive environment ➡️ janelia.org/graduate

Important and timely study Pregnant women face higher risks from Ebola: maternal mortality up to 89%, and nearly all pregnancies lost. Until now, they’ve been excluded from Ebola vaccine trials. A landmark phase 3 RCT in Rwanda changes [email protected] www.nature.com/articles/s41...

Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus model https://www.biorxiv.org/content/10.1101/2025.09.09.675144v1

We are hiring-join us!

Ultracold cryogenic TEM with liquid helium and high stability pubmed.ncbi.nlm.nih.gov/40911601/ #cryoem