In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization. authors.elsevier.com/a/1m3mV3qNrU... We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.

thanks!

LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu www.science.org/doi/10.1126/...

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

1/ David Baltimore passed away this weekend. He was one of the greatest biologists of the past 100 years. He made extraordinary contributions to immunology, cancer, molecular biology, virology, HIV, biochemistry, genetics, and genetic engineering. He won the Nobel prize in Medicine at age 37.

Rest in peace, David Baltimore. explorers.com/david-baltim... @nationalacademies.org @nobelprize.bsky.social

A germline-targeting trimer consistently induced rare bnAb-like precursors specific for the HIV Env Apex in rhesus macaques @sciimmunology.bsky.social @profshanecrotty.bsky.social War ad & Schief www.science.org/doi/10.1126/...

A good news article in Nature today following up on these papers www.nature.com/articles/d41...

After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social www.biorxiv.org/content/10.1...

In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations www.biorxiv.org/content/10.1...

Our wonderful LJI colleague Alex Sette was knighted this week! In recognition of his extraordinary contributions to immunology. As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.

News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd #medicine #health #ImmuneSystem #science #SanDiego

One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper… @cp-immunity.bsky.social www.cell.com/immunity/ful...