After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

🚨 New preprint! We show that intranasal FluMist vaccination induces local HA-specific memory B cell responses in the upper airway, even in the absence of strong systemic responses. Investigating local immunity will be key to designing improved vaccines for respiratory pathogens.