This was interesting and fun to do… seems Alphafold and the like have learnt what a Leucine zipper looks like… but not really.🤔 interesting that a fully synthetic leucine zipper that couldn’t possibly assemble looked pretty probable. 🧶🧬 doi.org/10.1002/pro....

Hey structural biologists submitting PDB’s from Oceania in 2026…. Keep those structures coming via the Japanese PDB node! 🤩

Lots of fun delivering a talk about how to use structural predictions in biological research to Perth Protein Group yearly meeting. Perth is lovely! Wish I could have stayed longer. Great to see old friends and meet some new ones #perthproteins

Celebrating the scientific legacy of Shin-Ho Chung to #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 on the Gold Coast with excellent presentations by Toby Allen, Ben Corry, Evelyne Deplazes, Elaine Tao, Jennifer Deuis, and @ciarawallis.bsky.social

Hearty congratulations to Assoc. Prof. Matthew Baker @phatmattbaker.bsky.social who was awarded the MacAulay-Hope Prize for originality and innovation in #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 at Griffith University Gold Coast campus.

🤩 I’m biased but… so sorry to have missed this.

DECRAs are out! Good luck young investigators. If you are unlucky- please don't let this moment define you. #ARC

Registration for #APSPM2026 closes soon. Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics. biosig.lab.uq.edu.au/strphy26 @official-smbe.bsky.social

The Wollongong crew have arrived in the gold coast for the #ASB2025 meeting! Just missing @lisannes.bsky.social who had presidential matters to attend to. Looking forward to the week of great science and catching up with the biophysics community in Aus!

Congratulations to Prof. Adelle Coster, UNSW, to whom I was honoured to present the 2025 Australian Society for Biophysics (ASB) Bob Roberston medal during ASB2025 at @griffith.edu.au. Adelle is pictured with ASB President, @lisannes.bsky.social; inaugural awardee Hans Coster; & myself 2009 medal.

@costalaboratory.bsky.social Nice presentation at the Australian Biophysics conference. Amazing series of Cryo EM structures.

🤩🥰 Exciting! Good luck 😉

Our ‘conservatives’ in Oz are debating dropping ‘net zero’ in favour apparently of burning Rome for personal gain. I do wonder at times if they can read, or if they ever go outside. Too busy counting their own pennies to see the bigger picture. How does this sit with Gen Y and Z? 🤔

This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬

🧶🧬 We present LMi4Boltz: www.biorxiv.org/content/10.1... Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.

Hey Tristan @crolltristan.bsky.social - thought you might have a giggle at this bit of AI... while Googling for a video to show someone Isolde, this AI summary about came up- are you feeling like a action-romance hero? 🤣🧶🧬

I’m finding it harder and harder to be here- not a statement about the state of bluesky, rather a statement about the world. What the hell went wrong with everyone??? I’m so sorry 😞. Our children deserve better. It’s so embarrassing for me to try to explain to my kids how we ended up here.

Just a heads up to anyone interested. @joshuamhardy.bsky.social will be presenting Protein DJ next week at the Australian Structural Biology Computing “Protein Design Seminars” hosted by @ausbiocommons.bsky.social www.biorxiv.org/content/10.1...

Do you like working on diverse projects with a range of researchers? New hire for a genomics/proteomics ( not structural biology) bioinformatician in the Mark Wainwright Analytical Centre at UNSW in sunny Sydney. Position hosted by the Stats Central team.

@sofiaisella.bsky.social “I can be your mother + the singles”. Amazing album. Spinning on the turntable on repeat.

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So lovely to see this story yesterday on SMC complexes presented by Prof Jan Löwe ( MRC LMB). It’s been a long journey and is still evolving but is a structural biology tour de force. @mrclmb.bsky.social @unswbabs.bsky.social

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😳😬 careful folks.

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👏 🧶 🧬 github.com/cytokineking...

🧬🧶 This is a really nice story integrating a number of methods to look at the evolution of a cool protein complex with a focus on protein structure. I love how biology keeps using the same tricks.

Protein people- this is a great conference! Recommended to get your registrations in. 🤩🧬🧶

Today’s paper club: @martinsteinegger.bsky.social @sokrypton.org @milot.bsky.social ( like an all star movie huh?) Looking forward to digging into this one. 🧶🧬

Friday night… 8 pm commute home… feeling like a punk rocker. Don’t forget your task as a scientist. Focus.

😳 Feels awkward being recognised when so many amazing people are behind the scenes in infrastructure development. But it’s good Structural Biology is getting some lime light and support. 🧶🧬 Thanks @brendanburns999.bsky.social

We are proud to announce our newest adventure! Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab! as.cornell.edu/news/philant... 🧪 🧬🧶 💫

🧬🧶 Useful. Many thanks Alexis.

Current world state: Approaching Ark B status, is it prepped and ready to go? Otherwise it’s a ‘so long and thanks for all the fish’ moment.

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🧬🧶Good opportunity people! Share around.

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Check out this weird protein we found in a Loki Asgard archaea.🧬🧶Only found relatives in other Lokis. 🤔 www.biorxiv.org/content/10.1...

Cool mechanism. 😎🧬🧶 Gotta love protein structure when you see stuff like this.

This was fun! Folding whole proteomes… looking at tomogram, looking at genomes🤩 lots to discover!🧬🧶

Not structure but useful to a lot of protein peeps.🧬🧶

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Last reminder- Dr Rhys Grinter webinar @rhyswg.bsky.social is on in just a couple of hours- click through to obtain the link. #proteindesign #structbiol You can sign up for future event information and reminders here: australian-structural-biology-computing.github.io/website/ 🧶🧬

Hey- anyone at FEMS20205 be sure to stop in to say hi to my amazing PhD student Steffi all the way from Oz🇦🇺! Check out her poster for a cool new Archaeal story- and demonstration of the power of protein structure prediction. Poster session: Section D, Tuesday, 15th July. Poster number: 241.15P 🧬🧶

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😳😱 not a smart move…🧬🧶

Any Protein Cosmos followers. The original feed will shut down in a few days. New feed is up and running- same avatar and name. Still perfecting the search (feed providers are different and have different algorithms). It’s an iterative work in progress. Polite feedback welcome.🧶🧬

Join us on 9 July 2025 for our free webinar 'Exploring macromolecular protein assemblies and their visualisation with @complexportal.bsky.social‬'. Registration is free, but essential: www.ebi.ac.uk/training/eve... Speakers: Sucharitha Balu and Kalpana Panneerselvam | @ebi.embl.org‬ 🧬 🖥️

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