🚨Excited to announce a new preprint from our lab, where we describe an ancient metabolic axis that controls mitochondrial genome copy number; a mechanism we uncovered in human cells that stretches through evolution to control mtDNA in flies, yeast and even plants!

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

Really elegant work, and something tells me the answer to the mammalian question is just around the corner 👏

Bravo 👏 @ryanlab.bsky.social - big moment for the lab and important findings re potential pathogenic mechanisms of mitochondrial disease

And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?... p.s. thank you @albertosanzmon1.bsky.social :)

For those who’d like a high level summary of our paper today, please check out the accompanying research briefing: www.nature.com/articles/s41...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Hugely important paper for those with an interest in how mitochondrial genetic diversity develops. Bravo 👏

Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

A fantastic lab and environment doing exciting science - check these guys out! 👍

While this is an interesting piece - there are quite a few issues that have slipped through peer review here: e.g. controlling for heteroplasmy levels in their patient associations (the mutation calls for which are not properly provided in source data) ED Fig 9 @natureportfolio.bsky.social

It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...

www.nature.com/articles/s41... What an effort!! Great news for the mito disease community 👏👏👏

Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

🆕Opportunity for a Computational Biologist/Bioinformatician to join @mito-oncogene.bsky.social leading on the interrogation and integration of multi-modal data arising from preclinical models and patients 📅Closing date: 7 February 2025 www.crukscotlandinstitute.ac.uk/careers/comp...

Really cool work from @ryanlab.bsky.social !! A lot to chew over here 👌👌👌

Really pumped to see our paper on how mtDNA mutations modify tumour biology with @edreznik.bsky.social & colleagues highlighted by the US National Cancer Institute’s Division of Cancer Biology as one of their advances of 2024! If you’re interested do check it out 😊 www.cancer.gov/about-nci/or...

Okey dokey here goes! First real post - please reshare if appropriate 🙏 🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔 We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

Hey #science people - new kid on the block, fresh from the other place, over here 👈 I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC. TLDR; science meets dad jokes 😎