The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @edreznik.bsky.social redefines what we know about human cachexia integrating genetics, lab values, and treatment lines. www.medrxiv.org/content/10.1...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

For those of you hunting for your next position, please consider applying for a postdoctoral position in our lab. Our science is wild and exciting, and I promise to train and feed (yes, w/free food) you well. It doesn't hurt that we are on a publication hot streak.

🚨New Review available online Scott M. Haake and colleagues provide an overview of recent research on biomarkers to predict immunotherapy response in clear cell renal cell carcinoma and discuss the predictive and prognostic biomarkers to prioritize in this context. www.nature.com/articles/s43...

🌟Technical Report online now Amy Xie, Wesley Tansey & Ed Reznik present the tool UnitedMet that imputes metabolite levels from transcriptomic data, and find oxidative phosphorylation associated with both BAP1 status and metastasis or therapy outcome in kidney cancer. www.nature.com/articles/s43...

Excited to tell you about a new method from our lab, UnitedMet, which imputes metabolite levels/ isotope tracing from RNA data. It features the best first sentence I've ever written: "Comprehensively studying metabolism requires metabolite measurements." www.nature.com/articles/s43...

Really cool work from @zampierilab.bsky.social Congratulations all!! www.nature.com/articles/s41...

Really pumped to see our paper on how mtDNA mutations modify tumour biology with @edreznik.bsky.social & colleagues highlighted by the US National Cancer Institute’s Division of Cancer Biology as one of their advances of 2024! If you’re interested do check it out 😊 www.cancer.gov/about-nci/or...

A culmination of ~5 years of work, today our work on biallelic alterations across tumor suppressor genes is published in @cellcellpress.bsky.social With Mark Zucker, Maria Perry, and Chai Bandlamudi www.cell.com/cell/fulltex...

A culmination of ~5 years of work, today our work on biallelic alterations across tumor suppressor genes is published in @cellcellpress.bsky.social With Mark Zucker, Maria Perry, and Chai Bandlamudi www.cell.com/cell/fulltex...