PGC-1α–mediated phospholipid synthesis plays a pivotal role in BAT thermogenesis in a sex-dependent manner in mice revealing a new therapeutic target for metabolic diseases in postmenopausal women. www.nature.com/articles/s41...

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency. t.co/m71gz29mUv

📢Article now online at Nature Cancer! 'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia' ✏️By Young-Mee Kim, Jalees Rehman and colleagues 🔗 www.nature.com/articles/s43...

A vascular perspective on #cancer cachexia here restoring endothelial PGC1α activity preserved vascular density and muscle mass in tumor-bearing mice @natcancer.nature.com www.nature.com/articles/s43...

Online now: RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

(1/3) Excited to share our latest work using @depmap.org to uncover a new synthetic lethality in two distinct patient populations! We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO #CancerResearch #SyntheticLethality #Genomics #DepMap

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬 Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L Congratulations to the DepMap team! @vazquezf.bsky.social #depmap #cancertarget #syntheticlethal

💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice. 👉https://rdcu.be/d8atv www.nature.com/articles/s41...

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to [email protected]. Please share! (1/2)

Very exciting findings @ppuigserverb.bsky.social connect mitochondrial ETC deficiencies with cancer cell immunogenicity expanding the repertoire of strategies to target tumor vulnerabilities

Online now! Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components. 👇 www.nature.com/articles/s43...

Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍

#mitochondria #cancer #keto

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity www.nature.com/articles/s43... @ppuigserverb.bsky.social @naturecancer.bsky.social www.nature.com/articles/s43...

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social www.nature.com/articles/s43...

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders

New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social rdcu.be/d5ptF

Our recent work on mitochondrial respiratory complexes @platorremuro.bsky.social highlighted in the DFCI Inside blog- Thanks to the Dana-Farber Editorial team for written this blog @danafarber.bsky.social blog.dana-farber.org/insight/2024...

This is a cool paper. A CRISPR/Cas9 loss-of-function library targeting nuclear-encoded mitochondrial genes and galactose-based screenings at various time points uncovers novel regulators of mitochondrial function www.biorxiv.org/content/10.1...

Structural basis of respiratory complex adaptation to cold temperatures www.cell.com/cell/fulltex... and Spotlight: Mitochondrial respiratory supercomplexes gear up for heat generation in brown adipose tissue www.cell.com/cell-metabol...

Thanks to Martin Ott, and Andreas Carlstrom, for this spotlight in Cell Metabolism- Mitochondrial respiratory supercomplexes gear up for heat generation in brown adipose tissue! www.sciencedirect.com/science/arti...

In the latest issue of Cell- Structural basis of respiratory complex adaptation to cold temperatures

Thank you, Weijia Gao, Biochemistry Student Oxford Univ www.ox-west.org/blog/my-summ...

Online! Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation by @mutlu_beste, @KfirSharabi, P. Puigserver @puigserver_lab, et al http://dlvr.it/TDlbH3

#FreeFeatured Targeting selective PCK1 and PGC-1α lysine acetylation causes anti-diabetic action through increased lactate oxidation by @puigserver_lab, et al. at @DanaFarber, @harvardmed http://dlvr.it/TFSC5f