Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques. doi.org/10.1038/s441... rdcu.be/eOBP0

Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy. doi.org/10.1038/s441... rdcu.be/eOoxB

Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target. doi.org/10.1038/s441... rdcu.be/eOeTA

Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach. doi.org/10.1038/s441... rdcu.be/eNFJV

Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets. doi.org/10.1038/s441... rdcu.be/eL2nN

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.

Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease. doi.org/10.1038/s441... rdcu.be/eKY2S

Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts. doi.org/10.1038/s441... rdcu.be/eKNZT

Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium. doi.org/10.1038/s441... rdcu.be/eKnDf

Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function. doi.org/10.1038/s441... rdcu.be/eKcfF

Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish. doi.org/10.1038/s441... rdcu.be/eJ3sB

Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes. @DelbridgeLab doi.org/10.1038/s441... rdcu.be/eJSl7

❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more! www.nature.com/natcardiovas...

Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work

Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy. doi.org/10.1038/s441...

❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more! www.nature.com/natcardiovas...

Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation. rdcu.be/eArYg doi.org/10.1038/s441...

Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation. rdcu.be/eym4W

Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts. rdcu.be/exm9t

Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury. rdcu.be/ewDHm

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! www.nature.com/natcardiovas...

Research | Yang et al draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of cardiovascular disease. doi.org/10.1038/s441...

Research | Jafari and colleagues reveal disease severity–linked right ventricle remodelling in pulmonary hypertension and identify key molecules, unveiling mechanisms of right ventricle recovery after pulmonary endarterectomy. rdcu.be/evlHO

Research | Li, Lu et al. Demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRE-dependent H3.3 deposition mechanism and facilitates vascular regeneration. rdcu.be/evbUz

Research | Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy. rdcu.be/euGtI

Research | Pocock et al. reveal that transient activation of 5’ AMP-activated protein kinase and oestrogen-related receptor drives robust maturation of human cardiac organoids, enabling the modelling of desmoplakin cardiomyopathy. @qimrb.bsky.social rdcu.be/et6S0

Research | Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a marker for embryonic coronary artery endothelial cells and a regulator of coronary vascular remodelling and morphogenesis. rdcu.be/etLrc

Research| Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and resulting cardiomyocyte death and cardiac dysfunction. rdcu.be/etxLM

❤️Our June issue is out❤️Read about the insight from the LILACS trial on T-cell regulation in cardiology, empagliflozin’s role in protecting the kidney and preventing heart failure in the EMPACT-MI trial, and more! www.nature.com/natcardiovas...

Research| Wang, Tang et al. develop an iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near the CCDC141, IGF1R, TTN, and TNKS loci. doi.org/10.1038/s441... rdcu.be/epB59

Research| Case et al. report that low-dose interleukin-2 clonally expands Tregs and maintains their suppressive program by bypassing BACH2 downregulation in patients with acute coronary syndrome from the LILACS trial. @aydencase.bsky.social rdcu.be/ephaW

Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions. rdcu.be/en0hU

Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. rdcu.be/enbAz

Research| Qian, Ugurlu, Fairweather, et al. generate more than 3800 #CardiacDigitalTwins from imaging and ECGs to reveal electrophysiological insights and their links to cardiac function, lifestyle, mental health and clinical outcomes. rdcu.be/em0NT

❤️Our May issue is out❤️Read our three articles focused on atherosclerosis, describing TLO-like structures within plaques, FDX1’s protective role, and how gut microbiota-derived bile acids suppress platelet activation, and more! www.nature.com/natcardiovas...

Research| Adamopoulos, Rovas et al. show that high regional wall shear stress correlates with fibrosis and electrical scarring in the left atrium of patients with atrial fibrillation, providing insight into the development of fibrotic tissue. rdcu.be/emh6y

Research | Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. rdcu.be/el1Xr

Research | Ling, Liu, and colleagues introduce MSR, a multiscale recursive algorithm that enhances cardiac microscopy for precise cardiovascular signal extraction, and validate the approach in vitro and in vivo. rdcu.be/elnFv

Review | Fankhauser et al. provide an in-depth review of preclinical mouse models used to study immune checkpoint inhibitor-associated myocarditis and discuss potential improvements to the field to strengthen our understanding. rdcu.be/ek2Dh

Research | Fan, Zheng, Zhan, Xu, Liu et al. reveal that the RNA-binding protein ARID5A drives inflammaging through the NF-kB-TBK1 pathway, and inactivating myocardial ARID5A attenuates cardiac senescence and functional decline. rdcu.be/ej7ww

Research| Li et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures within the plaques and their potential functions and implications. rdcu.be/ejPd5

Research| Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia-reperfusion injury. rdcu.be/eiiQf

❤️Our April issue is out❤️ Read about sex differences in atherosclerosis revealed by single-cell sequencing, how cardiac motion can be generated from electrocardiogram readings, the cardiac side effects of targeting immune checkpoint regulators, and more! www.nature.com/natcardiovas...

Research| Jimenez et al. show that CD40 agonists can induce myocardial inflammation by activating cardiac macrophages and CD8 T cells, sensitizing the heart to secondary injury and promoting adverse remodeling. @jjimenezlab.bsky.social #cardio-oncology #washU rdcu.be/ehHlK

Research| Sukhavasi et al. reveal sex-specific differences in carotid stenosis. Deep single-cell sequencing shows distinct phenotypes in smooth muscle cells: osteogenic in females and chondrocytic in males, highlighting potential therapeutic targets.

We highlight the study by Marcus et al. in @CircAHA, where the authors showed that a transseptal approach to catheter ablation can maintain the procedure’s anti-arrhythmic benefits while reducing brain damage. 👉https://rdcu.be/egl4s

Research| Li, Ni, Wang et al. identify CD248+ fibroblasts as key players in cardiac fibrosis, promoting fibroblast-T cell interactions. Disrupting CD248-mediated pathways shows promise in reducing fibrosis and improving heart function. 👉https://rdcu.be/efPj0