New in @science.org 🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs. www.science.org/doi/10.1126/...

Researchers from the Centre for Medicines Discovery delivered a successful public engagement event at the 2025 Green Man Festival. Their 'Medicine-Making Express' stall demystified the drug discovery journey for a national audience, engaging over 900 visitors. www.cmd.ox.ac.uk/news/cmd-dri...

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

Cryo-EM studies by the Bullock group @cmd.ox.ac.uk reveal how phase II drug UM171 and cancer mutations similarly reshape E3 ligase KBTBD4 to recruit neosubstrate HDAC1/2. This unexpected structural mimicry may inspire future degrader discovery. #TPD #CancerBiology rdcu.be/egdFy

The ODDI has been featured in a Wall Street Journal article, describing the use of AI in identifying and stratifying novel targets for therapeutic intervention in Alzheimer’s disease. www.wsj.com/articles/ai-...

Georgie Maynard and brother Charlie - LibDem MP for Witney, visited the Centre for Medicines Discovery, University of Oxford Brain Tumour Charity/CRUK funded research team led by Prof Daniel Ebner working on a five-year study to identify existing cancer drugs could shrink glioblastoma brain tumours.