house mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...

Happy to announce that HPAP now has some 180 human pancreatic analyzed by highly multiplexed CODEX analysis. Thanks to Dr. Powers and the whole HPAP team! Here is the link to the experiment data download page: hpap.pmacs.upenn.edu/explore/down... 🧪

Very proud indeed to have been together on a stage celebrating NIDDK's 75th anniversary at the recent ADA meeting in Chicago with Drs Rogers, Cefalu, Gubitosi-Klug and Kirscher. Always grateful for NIDDK's support of our research! 🧪

Very happy to share the results of a multi-national scientific collaboration on the factors that control telomere length. Hope you like it! Best, Klaus academic.oup.com/nar/article-...

I was truly honored to contribute as Keynote speaker to the 25th meeting of the European Islet Study Group in Malmo, Sweden. Fantastic meeting, lots of progress on all fronts! See you all next year in Barcelona!

Thank you, Christos, for the shoutout! It was a great honor to be invited as Keynote speaker to the European Islet Study Group conference in Malmo. Great meeting, I learned a lot!

What really happens at the onset of type 1 diabetes? The HPAP team profiled the immune system of the lymph nodes near the pancreas, the reservoir of the relevant immune cells. Read more here: www.nature.com/articles/s41... 🧪

Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to [email protected]

A wonderful day, celebration the recently graduated Dr. Michelle Lee at the UPenn hooding ceremony.

Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to [email protected]

Do the islet biology community, we have good news. Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB: hpap.pmacs.upenn.edu/explore/peri... 🧪

It appears that Biotech is no longer an attractive option 🧪 www.inquirer.com/health/spark...

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

Great to see thousands at the rally to save science in Philadelphia today! A truly inspiring event!

Dear Friends, Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...

While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia

I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding

It appears that NIH study sections (IRGs) are operating again

I should have put 🧪 in the first time to get this in the science feed. US science folks: Call!

My NIH Commons login stopped working today- anyone have similar issues?

ft. K. Trang, M. Pahl, J. Pippin, C. Su, S. Littleton, P. Sharma, N. Kulkarni, L. Ghanem, N. Terry, S. Anderson, B. Zemel, @alessandrachesi.bsky.social A. Wells, @struangrant.bsky.social, J. O'Brien, W. Yang, @ptitchenell.bsky.social P. Seale & @kkaestner.bsky.social elifesciences.org/articles/95411

Up front & free to read in our Jan issue #editorspicks: Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity tinyurl.com/bdf9ec33

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Collaborative science at its best - discovery of new loci AND relevant cell types in childhood obesity. elifesciences.org/articles/954...

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social. If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X www.science.org/doi/10.1126/... #RNASky #ImmunoSky

AI algorithms can accurately figure out a person’s ‘MileAge’ or metabolomic age using molecules generated during the metabolic processes like digestion.🧪https://www.science.org/doi/10.1126/sciadv.adp3743

Very excited to share our new paper just out in Science Translational Medicine. Using human genetics and mouse models we show that G6PC2 is critical for controlling glucagon secretion, and suggest this enzyme as a potential drug target for diabetes treatment. www.science.org/doi/epdf/10....

Somewhat fewer review invitations would be nice Happy Hanukkah and Merry Christmas, and hoping for a more peaceful 2025

This is amazing AND crazy, and reflects how complex our immune systems are and how much we still have to learn... 🧪 Looking forward to reading it in full

Happy to share that our “IsletTester” mouse strain has not been accepted by the MMRRC for free distribution to academic labs. Strain number is 71912. You can go to their website to register your interest. Hope the mouse is useful for your work!

Arctic tundra once stored carbon. Now it emits climate-warming pollution - NPR 🧪 #AGU24 www.npr.org/2024/12/10/n...

Another argument for publishing in society journals - just got my bill from Diabetes- $1600 for publication costs At Cell Metabolism it would have been four times that …

Very happy about our new paper in Diabetes, where we describe the "IsletTester" mouse, a new stably hyperglycemic, immunodeficient model for the testing of human islets or stem cell derived beta-like cells. These mice will be made available via the MMRRC. Hope you will find them useful!

Dear Friends, Like a lot of my colleagues, I decided to move from Twitter/X (@KlausKaestner) to BlueSky. Hope to meet you all here! Best, Klaus