Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky

Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠

Application for 2025/2026 RNA Salons is now open. Please apply by 31st August to receive support your local or regional RNA activities. @rnasociety.bsky.social #Lexogen www.rnasociety.org/salons

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

Registration for A-RNA 2025 is now open!!! Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events Register: www.a-rnameeting.org.au/registration Early bird rate ends July 30th, 2025 #RNASky

I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting

RNA xkcd.com/3056

Today is Rare Disease Day Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au Five rare diseases and support groups:

Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇

Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5? #RNASky #ImmunoSky

Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.

#RNAsky #RNAbiology

#IL_NAT25 Yuval Dor on RNA editing in diabetes. Thought inflamation caused by virus, but no virus found. Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation? Data indicates yes, by ADAR KO mouse model. Phenotype similar to progression of diabetes in humans

The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions. #RNASky #Immunosky

Waiting for flight back to Oz and reflecting on the awesome @keystonesymposia.bsky.social last week on #RNA mediated regulation of #immunity. Here are a few highlights with links to the published or preprinted papers which you should definitely check out if you haven't yet ... #RNAsky #Immunosky

Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity" They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly. www.sciencedirect.com/science/arti...

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention #RNAbiology #RNAlocalization www.nature.com/articles/s41...

Proud to share our paper on the impact of transcription inhibition on mRNA export in cancer. A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

RNA sensing induced by chromosome missegregation augments anti-tumor immunity www.cell.com/molecular-ce...

Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social! www.nature.com/articles/s41... #RNA #RNABiology #RNAsky #Translation #mRNA

Very important study to consider in light of the many miRNA cancer network and association studies out there!

Heading to @3rrrfm.bsky.social radio to discuss some of our science on #innateimmunity #inflammation #RNA sensing and what this could mean for new #mRNA therapies. If you’re in Australia, tune into Einstein-A-GoGo this morning at 11 am. Podcast link to follow! @hudsonresearch.bsky.social #immunosky

Another year, another science-themed cake for the @hudsonresearch.bsky.social CiiiD EOY party! This edible board game is made from gingerbread & royal icing, with a hidden medovik (honey cake) inside! It was a labour of love but lots of fun to make! #sciencesky #immunosky #bakingsky #sciencebakes

Very cool story! A good example of how chasing the weird thing you see in sequencing data can lead to exciting new discoveries. #RNASky #RNABiology #ImmunoSky

Out of the oven from my group! APAtizer, to simplify the analysis of alternative polyadenylation events using RNA-Seq data: academic.oup.com/bioinformati...

Hello Bluesky 🤠 Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

SERVICE UPDATE We normally don't ask you to "share like and subscribe" but please distribute this. You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research. #AcademicSky #Medsky #HigherEd

Really beautiful RNA structures from Rachel Kretsch in the Das and Chiu groups These look like viral capsids but they're only RNA!! Hopefully this unlocks more work on "ornate" RNAs 🧪 www.biorxiv.org/content/10.1...

Who else is coming to this #KSRNAImmune25? I'm very excited for a conference covering my two favourite topics, RNA and Immunity all in one! #RNASky #ImmunoSky #RNABiology www.keystonesymposia.org/conferences/...

www.cell.com/molecular-ce... #RNASky #RNAbiology

Excited to share this #Insight we wrote with Erika Valeri for @jexpmed.bsky.social on works by Chan et al. (hubs.la/Q02-JGLM0) & Ru et al. (hubs.la/Q02-JK4r0) that identify defective RNA processing as the root cause of impaired antiviral immunity in the human brainstem rupress.org/jem/article/...

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social. If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X www.science.org/doi/10.1126/... #RNASky #ImmunoSky

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

Our newest publication is out! N-6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs www.life-science-alliance.org/content/8/2/... Here is a short 🧵: (1/n)

mRNA-encoded transcription factor inhibitors are a rapidly emerging class of drugs. In Science Translational Medicine a team at Harvard treated retinal disease in animals by inhibiting RUNX1. Stay tuned for our forthcoming work targeting cancer transcription factors. www.science.org/doi/10.1126/...

Calling all B and T cell enthusiasts!!!! Get in touch with @precisionvaxlab.bsky.social if you are looking for a job! She’s an incredible scientist and mentor, who really fosters a positive work environment with exciting projects that have health impact. #immunosky #academicchatter

Altmetric now tracking on Bluesky! But take note that short links (bitly etc) and deletion of the actual link after embedding can’t be tracked. See 🧵 👇

Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...

Hi genetics community, I’m new here & will introduce myself via our recent publication mapping the genomic landscape across Australian Indigenous Communities. Key findings include deep population structure, rich novel variation and extreme patterns of haplotype sharing and homozygosity.

Consistently a number of events that were believed to be through DNA damage are through ribosome signaling triggered by damaged RNA. An amazing new area

How cool. A little animation of our paper! Thanks @immunosketch.bsky.social!

If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs

Hi #RNAsky, I've made a much needed #RNA modifications starter pack! Let me know if you’d like to be added or know someone who should be. go.bsky.app/E7zXGSF #RNAmodifications

RNAkinet identifies nascent RNA by predicting 5EU metabolically labeled #RNA from raw #nanopore electrical signal. Should allow association of RNA metabolism dynamics with isoform usage, poly(A) tails and native RNA mods. academic.oup.com/nargab/artic...

This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!

Next up is @SaraMaciasRNA discussing how DGCR8 acts as a gatekeeper of the interferon response by preventing cytoplasmic TE-dsRNA accumulation #GStransposons

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...