🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

I’m really excited to begin this next chapter for my research at @wehi-research.bsky.social later this year. I also want to take this opportunity to sincerely thank all my colleagues from @monashuniversity.bsky.social for their support these past 5 years.

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab

Congrats @linterman.bsky.social @smguillaume.bsky.social and team for this nice study about B cells fighting on the front lines (the 🫁)

New preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...

I’m so excited to be a chief investigator for this $10M Wellcome Trust grant, and for all the important things we’re going to learn about immunity against Strep A with researchers spanning three continents.

Kicking off the new year searching for a postdoc to join our team @wehi-research.bsky.social Apply now and spread the word

Really important #ImmunoSky findings from @jenjuno.viralvaxlab.com and co-authors about the pitfalls of using activation markers to detect antigen-specific T cells. Good news is they’ve found a marker combination that gets rid of bystander activated cells! Check out the preprint and 🧵 below 👀

8/9 In short, we suggest in vitro stimulation activates ag-specific T cells, which secrete cytokines and activate Treg and Th17/22 cells. Without careful phenotyping, all of these cells can get picked up as AIM+, accounting for the Th17-like memory cells found in many virus-specific AIM datasets.

My n=1 experiment confirms that this scientifically tested recipe makes a delicious Cacio e Pepe, and the pre-print is surprisingly thorough!

Finally jumping into 🦋 - and what better way to do than highlighting this super thread. Wonderful to have been involved in this study with our Strep A friends across the Tasman

This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV

🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky

Hi everyone still plenty of room in the B cell starter pack please message if want to join the party! go.bsky.app/8avwjYw

This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!

Today I had a collaborator say “I never share my findings with anyone before they’re published. I’ve been burnt before”. It’s got me wondering how widespread ‘getting burnt’ is in science. 🤔 #ImmunoSky I’m keen to hear horror stories and what impact it had on your approach to science!!

I spent this last week at Biomolecular Horizons conference in Melbourne and fell in love with the “Stories and Structures” art exhibit on display from Microscopy Australia. (1/2) It’s worth a look! micro.org.au/stories-stru...

My X feed is mostly gun violence and pro-Trump nonsense. Time for a radical change! Hoping to find the twitter community I’ve lost. I’m interested in all things immunology, but particularly adaptive immune responses to vaccines and infectious disease. Bring on bluer skies!