We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM

WEHI researchers have helped to engineer an antibody that can clear otherwise lethal multidrug‑resistant Acinetobacter baumannii infections in mice by homing in on the bacterial sugar pseudaminic acid. Brilliant findings, published in Nature Chemical Biology www.wehi.edu.au/news/sugar-m... 🧵1/2

🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2

GLYCO-BUILD, an entirely enzymatic approach for the production of N-glycans and N-glycopeptides. www.nature.com/articles/s41...

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.

🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉 🏅 Protein Metrics ECR Awardee - Dr Jonathan Du 🏅 SHIMADZU MCR Awardee - Prof Morten Andersen Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org A huge thanks to our sponsors for supporting these awards 👏

The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel... #ChemNobel #Chem #Chemistry #chemsky 🧪

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ... So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵 This is a repost from X because you all need to know! #NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience @nhmrc.bsky.social

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social chemrxiv.org/engage/chemr...

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

Beautiful enzyme evolution work by Steve Withers and coworkers 👏 pubs.acs.org/doi/10.1021/...

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Last but most certainly not least, The President’s Innovator Award 2025 goes to Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂

#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes www.nature.com/articles/s41...

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.social

ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...

Introducing Latent-X — our all-atom frontier AI model for protein binder design. State-of-the-art lab performance, widely accessible via the Latent Labs Platform. Free tier: platform.latentlabs.com Blog: latentlabs.com/latent-x/ Technical report: tinyurl.com/latent-X

❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/... #CryoEM #apoptosis #mitochondria #BAX

New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3 doi.org/10.1101/2025...

Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery. For more information and to apply 👇

www.wehi.edu.au/careers/make... WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social

Excited to share our new Nature Communications paper describing the molecular structure and the biochemical characterization of human #collagen #galactosyltransferase GLT25D1/COLGALT1 #glycotime www.nature.com/articles/s41...

After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors. www.nature.com/articles/s41...

Society for Glycobiology wishes to speak. www.glycobiology.org/index.php?op...

41% of external molecules licensed by large pharma so far in '25 are coming from China said Stifel's Tim Opler on Fri's Biotech Hangout. This is up from 31% in '24. It was 0% in '19. Data from DealForma/CEO Chris D. The # of upfront $ for China biotech licensing deals increased too he said #biosky

Incredibly excited to share Dr Alisa Glukhova has been awarded a prestigious @SnowMedical Fellowship - the only recipient this year! She'll receive $8M over 8 years to advance her groundbreaking #cancer research. 🔗 www.wehi.edu.au/news/wehi-ca...

🔬 #Glyco27 Keynote Speaker Dr. @ethangbaus.bsky.social (Walter and Eliza Hall Institute of Medical Research) studies tryptophan C-mannosylation—a rare glycosylation that impacts protein stability & parasite biology. Catch his talk at Glyco27! 📢 Register: www.glyco27.org/en/begin

Mike spotted this before the rest of us. 🫡 Publications from 2025 are shared more on Bluesky than on X/Twitter.

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Thanks to Ratmir Derdra, our #glycotime answer to "The risk of mirror life" appears now under the article in Science www.science.org/doi/10.1126/... With @glycoexpasy.bsky.social @laurakiessling.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social and many

"Remember The Glycans", a response to "Confronting risks of mirror life", argues an assessment of the threat of mirror-image life forms requires careful consideration of glycans. Authors include R. Derda, @carolynbertozzi.bskyverified.social and F. Lisacek who leads our Proteome Informatics Group.

Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈 www.biorxiv.org/content/10.1...

Thanks to Ratmir Derda we have an articulate reply to: www.science.org/doi/10.1126/... putting glycans back into the picture! @laurakiessling.bsky.social @anneimb.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social @siglecdude.bsky.social

and more... @glycosmos.bsky.social @glycocode.bsky.social @chrrademacher.bsky.social @ethangbaus.bsky.social and again more but bluesky handle found @glyconet.bsky.social @sib.swiss

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬 For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true! Read the preprint: biorxiv.org/content/10.110… And find our tweetorial below#glycotimeme

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...

Really impressive work! Congratulations to everyone involved!

Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks. Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible). 1/n

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

Our new paper on #Dictyostelium glycomics is online (typeset version to follow). Lots of wierd structures in D. purpureum & D. giganteum - species-specific galactosylated 🟡 or fucosylated 🔺 antennae, plus the sulphate and methylphosphate typical of D. discoideum. #glycotime doi.org/10.1016/j.bb...

Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime www.science.org/doi/10.1126/... 🧪

It’s #glycotime Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains www.nature.com/articles/s41...

Our January issue is live and it’s our 20th Anniversary Issue! www.nature.com/nchembio/vol... It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.