We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions #glycotime www.nature.com/articles/s41...