This is the first @smartsymposium.bsky.social , Decoding the Glycome. We have lined up fantastic speakers, including experts in glycosylation and tool developers whose technologies hold exciting potential for applications in glycoscience. We look forward to welcoming you to Shenzhen this November

Sharing our latest work on B cell Siglecs in regulating antibody production. Unlike our previous work (PMID: 35294874), where we found that CD22 (Siglec-2) positively impacts the germinal center (GC), our new work uncovers a regulatory role for Siglec-G in the GC: www.biorxiv.org/content/10.6...

Excited to share some work that our lab co-led with @veredpk.bsky.social. Lots of data for anyone interested in Siglecs. Great work from Edward Schmidt with big support from @zeinab-jc.bsky.social. www.nature.com/articles/s41...

Check out the super cool collaborative work with @elisafadda.bsky.social. Very cool modelling!

Interested in glycan-binding proteins in Immunity? Check out this review with Gabriel Rabinovich, @chrrademacher.bsky.social, and Mirta Schattner on this subject. www.annualreviews.org/docserver/fu...

Immune cells use sugar molecules on their surfaces to communicate—but these signals can be hard to study. GlycoNet researchers at @ualberta.bsky.social developed balloon-like probes to help detect these subtle interactions, opening doors for future therapies. 🔗 canadianglycomics.ca/balloon-like...

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem: 🔗 www.jbc.org/article/S002... Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

@pengwu.bsky.social put together a stellar lineup of speakers. Was just fun listening and fortunate to contribute.

Nice discussions and turnover @pacifichem.bsky.social

Come for the science. The location is pretty outstanding too.

Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...

When glycan recognition is linked to immune response, you need fine tuning! 😎 Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️ doi.org/10.1101/2025...

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social. www.biorxiv.org/content/10.1...

A little story we put together that I hope can be useful: pubs.rsc.org/en/content/a.... More to come on this work related to this in the future.

Our review on the recent acceleration of research into carbohydrate Sulfation as as an enhancer of Siglec ligands: www.sciencedirect.com/science/arti...

Highly recommended listening to @ghazeskandari.bsky.social if you are interested in immune cells of the brain.

We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...