Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease | Science Translational Medicine www.science.org/doi/10.1126/...

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Really excited to share this work from @blurtonjoneslab.bsky.social lab, “Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

Thanks for putting together such a fantastic meeting, and for the opportunity to present! It was great to be part of the conversation with the rest of speakers.

👏 Great start to NextGen 2025! S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease Hosts: Kristine Freude & Marion Kadlecová Speakers 🔹 Ghazaleh Eskandari-Sedighi 🔹 Lukas Busch 🔹 Johannes Schlachetzki 🔹 Zhiyuan Ning 🔹 Guoyan Zhao

Are you an ATP!?! We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs). Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY. Apply here! rb.gy/3zk4cm

Identification of CD33m as a new protective factor in Alzheimer’s Disease development. Read about this research by Brain Star Award winner Ghazaleh Eskandari-Sedighi can-acn.org/brain-star-a... @ualberta.bsky.social @ghazeskandari.bsky.social

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Join us for the next GTA webinar on Siglecs and their glycan ligands, featuring Dr. @siglecdude.bsky.social (U of A) and Dr. Edward Schmidt. Learn how their team is developing novel tools to uncover the biological roles of Siglecs across systems. Register: canadianglycomics.ca/training/web...

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development. journals.biologists.com/dev/article/...

What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

The registration for the second round of 2025 Canadian Neuroscience Series are open now. This was a fantastic opportunity for me to learn about the impressive work of other #postdocs and share mine with them. Highly recommend it to anyone eligible in the field of #Neuroscience.

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT. Find more details here: tinyurl.com/56m946jh Apply through this form: tinyurl.com/42cwhae3

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Thanks to @canacn.bsky.social and #CIHR for choosing my work on human CD33 isoforms in Alzheimer’s disease for a #brainstar_award. I share the credit with Matt Macauley lab @siglecdude.bsky.social and all the amazing co-authors whose tremendous help was a huge contribution to this project.

Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati... Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...

Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi... And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

Happening THIS week! Register here: zoom.us/webinar/regi... Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h

The Alzforum note on the newest publication from Blurton-Jones lab: "Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain" www.alzforum.org/news/researc...

We are back next Thursday (May 1st) with two wonderful presentations 📅 Register now: zoom.us/webinar/regi... And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease @cp-cellstemcell.bsky.social sciencedirect.com/science/article/pii/S1934590925000992

Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social. Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS

Congratulations to Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍 www.sciencedirect.com/science/arti...

This amazing news made my week! 🎊 I’m beyond blessed to be part of the @brightfocus.bsky.social community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @blurtonjoneslab.bsky.social and the entire MBJ team for their continuous support!

#fluorescencefriday. Let’s take a look at the brain vasculature with this rendered video in a whole mouse brain. 🧠 Labelled with CD31 by @shahrzadbahrampour.bsky.social

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com www.nature.com/articles/s41...

Happy Spring Solstice, and happy Nowruz to all who celebrate this special day 🌷

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41... 1/3

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...

A nice response from Dennis J. Selkoe to Charles Piller’s claims about Alzheimer’s disease research in his recent book “Doctored”. “Piller will try, but he cannot win this argument on the facts.” www.statnews.com/2025/02/14/a... via @statnews.com

Please see a collective response from an esteemed group of leaders in the dementia field to the NYT article and book “doctored” by Charles Piller. www.nytimes.com/2025/01/24/o...

We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...

New advertisement posted: Postdoctoral position in Neuroimmunology – Mccauley lab – University of Alberta can-acn.org/postdoctoral... #neurojobs

Super excited to be presenting at CNS-PDS 2025 seminar series! Looking forward to hearing about all the great work of my fellow #Canadian #postdoc colleagues.

Excited to share our recent paper where we use genetics, bioinformatics, and cell-based functional studies to determine whether variants of unknown significance act as pathogenic variants to cause autosomal dominant Alzheimer’s disease @alzassociation.bsky.social

This is so important. Consequences of microglial depletion differ by sex. www.cell.com/cell-reports...

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

Alzheimer’s disease deaths lowest among taxi and ambulance drivers. #BMJ "Findings raise possibility that frequent spatial processing tasks might offer some protection against Alzheimer’s disease" Fulltext: press.psprings.co.uk/bmj/december....

Congratulations to Michael Mgerian on his graduation. Michael joined the @blurtonjoneslab.bsky.social lab as an exceptionally talented 2nd year student, and I’ve had the pleasure of working with him on many cool projects ever since. He is without doubt a rising star! Onwards and upwards Michael! 🎉

Happy holidays to you all, and most definitely to the amazing team behind @atqmovie.bsky.social - Pamela, you are a force, and the movie is going to be amazing. Support the cause if you can, share the message if you can't.

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

Reduced protein mobility (proteolethargy) is a pathogenic mechanism in chronic disease @cellpress.bsky.social www.cell.com/cell/fulltex...