How do PTMs affect the binding of small molecule drugs to their target proteins? Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline". Blog post: www.science.org/content/blog... Paper: www.nature.com/articles/s41... (1/4)

Findings from Prof. Chris Parker's lab show that post-translational modifications (PTMs) can determine whether proteins bind drug-like molecules. Published in Nature Chemical Biology, the study identified 400+ proteins whose druggability depends on modification state. More: https://ow.ly/3OQj50YVecw

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

Congrats Ben!

Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins. This was a big team effort led by @inesforrest.bsky.social and in collaboration with AbbVie.

Check out our recent collaboration with @abbvie.bsky.social in @cp-cellchembiol.bsky.social. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).

Happy to share the finalized version of this work out in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...

Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation. Nice work Wesley and Roy! pubs.acs.org/doi/10.1021/...

Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

“Probing the proteome” www.nature.com/articles/s41...

A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Beyond thrilled to share that my PhD work is now available as a preprint! 🥳 A huge thank you to my amazing colleagues, mentors and collaborators at @scripps.edu and @abbvie.bsky.social who supported and contributed to this project!

The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social www.biorxiv.org/content/10.1...

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...

I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start. If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes chemrxiv.org/engage/chemr...

Insightful perspective by the group of Ben Cravatt with first author @xiaoyuzhang.bsky.social in @nchembio.bsky.social. They discuss reasons, why expanding the repertoire of E3s for TPD has converged on few "frequent hitters" and how additional E3 targets could be identified. doi.org/10.1038/s415...

Congrats Ben!!!