By reprogramming the tumor microenvironment with an engineered virus, @quintanalabhms.bsky.social boost anti-tumor immunity against glioblastoma. @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...

🔔 New episode alert! Dr. Ana Anderson from Harvard Medical School talks about her work on #ImmuneRegulation in cancer. ▶️ https://bit.ly/4pJvw4u

Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School! Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.

Review @natrevneuro.nature.com Immune dysfunction in Alzheimer disease www.nature.com/articles/s41...

Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner #neuroscience #neuroskyence www.nature.com/articles/s41...

Beautiful work!

The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges. Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social | Science www.science.org/doi/10.1126/...

Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com "Neuropeptide signalling orchestrates T cell differentiation" www.nature.com/articles/s41...

We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social! We’re thrilled to welcome experts, ignite new ideas, & push the field forward. Huge thanks to our incredible sponsors for making #RTN2025 possible! 🧵👇

#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari

This conference is going to be great! Looking forward to it.

This conference is going to be great! Looking forward to it.

Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com. @genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org hms.harvard.edu/news/researc... www.nature.com/articles/s41...

REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab www.nature.com/articles/s41... preview @theonlylabever.bsky.social www.nature.com/articles/s41...

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org. PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved. From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab. Study led by #LingjiaKong @broadinstitute.org

New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...

Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...

Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th. 🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman. Joseph B. Martin Conference Center, Boston MA

Have you registered yet for #ReThinkNeuroimmunology in October? Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity. Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social www.cell.com/cell-reports...

Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!

(1/6) Our latest paper in ‪@cp-cellhostmicrobe.bsky.social‬ shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway. www.cell.com/cell-host-mi...

Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org

Out now in @Science! We and the @kuchroolab.bsky.social described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity www.science.org/doi/10.1126/...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense www.science.org/doi/10.1126/... @science.org @kuchroolab.bsky.social @thexavierlab.bsky.social

New research from @quintanalabhms.bsky.social show how glioblastoma co-opts TRAIL-positive astrocytes to suppress anti-tumor T cell function. Now published @nature.com www.nature.com/articles/s41...

So great that Brenda & Jason gave us daily recaps of their favorite talks at #AAI2025 via @immunologypodcast.com. 🌟Episode 5 features a talk by Ana Anderson on how opioids drive immunosuppression in T cells in cancer. Listen to all the episodes for highlights from the🧪 @aai.org conference👇

A new study raises the odds that a strategy already successful against some cancers may be deployed against Alzheimer’s. From @kuchroolab.bsky.social and colleagues, co-first authors Kimitoshi Kimura and @ayshwaryas.bsky.social news.harvard.edu/gazette/stor...

@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!

Immune cells boost stress-linked fear responses by communicating with brain cells. Psychedelics can modulate this interaction, lessening such fear https://go.nature.com/4ixzclU

Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the @harvard.edu Gazette 👇 🧪 news.harvard.edu/gazette/stor...

Nature research paper: Psychedelic control of neuroimmune interactions governing fear https://go.nature.com/4iriy7u

Psychedelic compounds regulate neuroimmune interactions to control stress-induced fear. Study from Michael Wheeler & colleagues @genelayinstitute.bsky.social, @massgeneralbrigham.bsky.social @harvardmed.bsky.social. Now published @nature.com www.nature.com/articles/s41...

Congratulations to the Michael Wheeler lab et al. on this elegant study showing the underlying mechanisms of how psychedelics influence neuroimmune interactions, with implications for fear behaviour. Delighted to be able to contribute to this work. www.nature.com/articles/s41...

#ReThinkNeuroimmunology 3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology. Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Registrations 🔗 genelayinstitute.org/rtn/

Nature research paper: Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease https://go.nature.com/4i6HG3r

Register for #ReThinkNeuroimmunology 2025 at 🔗 genelayinstitute.org/rtn/

🚨Registrations now live! Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Register here: genelayinstitute.org/rtn/

Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social. Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

Grateful to share our study on the potential for immune checkpoint blockade in late-onset #AlzheimersDisease out @nature.com today. Co-led with Kimi, Zhuoran, Ahad @kuchroolab.bsky.social in a big team effort @genelayinstitute.bsky.social @broadinstitute.org @harvardmed.bsky.social  /1

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...