Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....

The four astronauts aboard NASA's Artemis II mission are about to plunge through the atmosphere toward Earth, after a successful visit to the moon. n.pr/4spkBOo

So cool www.nasa.gov/missions/art...

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...

If dendritic cells are part of your science, #DC2026 should be part of your year! 🌍Global DC community in San Diego ✳️New biology & discoveries Abstracts & registration are OPEN www.dc2026sandiego.com ⭐️ Come for the science. Stay for the community. @maxkrummel.bsky.social @zunigalab.bsky.social 🔁

@ucsdimmunology.bsky.social We have plenty of free parking

Another great speaker @gottschalklab.bsky.social coming to @lji.org. Come join!

HCF1 orchestrates O-GlcNAcylation and affinity-dependent transcription through extended molecular determinants and register-shifted binding https://www.biorxiv.org/content/10.64898/2026.03.19.712392v1

Why can’t people (especially scientists) see that AI generated figures and diagrams shout out that they were AI generated and look awful? You’ve spend many months designing and performing experiments only to cover the resulting masterpiece in clear plastic like a cheap sofa.

If you or someone you know has reviewed or been awarded a Human Frontier Science Program (HFSP) Program grant, can you contact me? Thanks in advance.

This is what studying O-GlcNAc feels like, w/ @lucasbsullivan.bsky.social #glycotime

A druggable redox switch on SHP1 controls macrophage inflammation https://www.biorxiv.org/content/10.64898/2026.02.19.706790v1

New preprint! TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses www.biorxiv.org/content/10.6...

To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D. bio-protocol.org/e5607

I’m recruiting new members to the Farrell Lab this summer. We will have space for 1 postdoc (since Abhinav is leaving to start his own lab at U Arizona!!) and 2 postbacs, since my current two will leave for PhD programs at the end of the summer. More details in thread:

Please 🔁 My group at UBC received an allocation from the school to apply for the Canada Impact+ Training Awards (postdoc). Everything is moving fast but please email me in 48 hours with a CV if you are outside Canada and interested😎 Yachie lab: yachie-lab.org sshrc-crsh.canada.ca/en/funding/o...

Has anyone tried hiding text in grants and manuscripts that tell AI readers this is great work? Asking for a friend....

You can't think out of the box if you don't think. For how i see it this is not an inherent problem of AI, which at the end it's just at tool (for now). It's rather a problem inherent to us, human beings (aka lazy bastards).

Come join next week @lji.org!

cool

Happy #MassSpecMonday! Explain mass spectrometry badly in one sentence. We’ll start: “Yeet molecules into a vacuum and see who panics first.” Your turn 👇 #ASMS #TeamMassSpec #MassSpecCommunity

The best thing one can do for technicians who want to go to graduate school is to teach them how to plan an experiment properly. Maybe even full project considerations. They come in so much stronger.

jealous

Lab holiday dinner. Delightful all around. @samyers-lab.bsky.social @lji.org #blessed

cool

Imagine training for years or even decades to critically analyze and interpret data and graphs and then just having some program summarize a paper based on whatever the authors have written. Crazy.

@seth-shipman.bsky.social does it again.

LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics! We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets. Check it out here: doi.org/10.1002/pmic...

Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. Learn more: https://scim.ag/4ln58Le

So cool.

In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...

🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!

We make cell engineering look easy....

Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social

A generation of scholarship, put on hold or lost. share.google/5Pw7Akh79qec...

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation. www.nature.com/articles/s41...

Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation #glycotime #Glycobiology

🍹Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating #ferroptosis sensitivity, #tumor development and chemoradiotherapy efficacy. 👉https://rdcu.be/eAN1I bit.ly/3JasCWN

Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com www.nature.com/articles/s41...

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

What... on earth...am I looking at?!?

you can unclench a little bit....