cool

Happy #MassSpecMonday! Explain mass spectrometry badly in one sentence. We’ll start: “Yeet molecules into a vacuum and see who panics first.” Your turn 👇 #ASMS #TeamMassSpec #MassSpecCommunity

The best thing one can do for technicians who want to go to graduate school is to teach them how to plan an experiment properly. Maybe even full project considerations. They come in so much stronger.

jealous

Lab holiday dinner. Delightful all around. @samyers-lab.bsky.social @lji.org #blessed

cool

Imagine training for years or even decades to critically analyze and interpret data and graphs and then just having some program summarize a paper based on whatever the authors have written. Crazy.

@seth-shipman.bsky.social does it again.

LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics! We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets. Check it out here: doi.org/10.1002/pmic...

Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. Learn more: https://scim.ag/4ln58Le

So cool.

In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...

🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!

We make cell engineering look easy....

Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social

A generation of scholarship, put on hold or lost. share.google/5Pw7Akh79qec...

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation. www.nature.com/articles/s41...

Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation #glycotime #Glycobiology

🍹Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating #ferroptosis sensitivity, #tumor development and chemoradiotherapy efficacy. 👉https://rdcu.be/eAN1I bit.ly/3JasCWN

Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com www.nature.com/articles/s41...

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

What... on earth...am I looking at?!?

you can unclench a little bit....

After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Why call? Why sign letters? Why protest? What does it do?? It. Adds. Up. And PRESSURE WORKS! Keep it up, Dorks! #StandUpForScience www.politico.com/news/2025/07... 14 Republican senators urge White House to release delayed NIH funds - POLITICO

Let's put Black Sabbath in context. In the 60s, rock & roll was ruled by Jimi Hendrix, etc. and they were all heavy by volume standards, but you know you put on one of their records. It's not going to ruin the vibe. BLACK SABBATH WAS THERE TO RUIN THE VIBE recorder.google.com/87365ff3-08d...

If you merely recite what the president *says is in a trade deal, you’re committing journalism malpractice

Always love TF PTMs

If you had time to make a poster and/or march you have time to call your representative.

We try to post all our work as PDFs on our website. It's usually kept up to date.... www.samyerslab.org/publications

I tried to express, purify, and characterized this kinase in college. 20 years ago, jeez.

Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social ! www.biorxiv.org/content/10.1... This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA. 1/?

Dense cities have more walkers, and each additional kilometer of bike lanes creates approximately 13,400 additional kilometers of bicycle travel, according to data on travel modes for 11,587 cities containing 2 billion people. In PNAS: www.pnas.org/doi/10.1073/...

New Preprint!! Alejandro González-Delgado accomplished a major feat on this one: ported retron recombineering, which we love so much in E. coli, into 14 new bacterial species via a massive collaborative effort involving 9 labs! www.biorxiv.org/content/10.1...

Very cool approach

Trump parade vs No Kings march, San Diego

#Nokings San Diego

Water saturated with baking soda for year gas. Soapy water for pepper spray. 🤙

It is so satisfying to see neurodevelopmental-associated mutations found in humans recapitulated in mice. Molecular characterization of these mice provides such strong insights into dysregulation mechanisms. More to come too... elifesciences.org/articles/103... @lji.org

“I've seen things you people wouldn’t believe. Sequencers illuminating creation off the shoulder of Boston. I watched mRNA vaccines glitter with hope in the dark of the pandemic. All those moments will be lost in ignorance, like tears in rain. Time to defund.”

So cool. So jealous. Omnitrap installed and characterized in an Exploris.

This is stepping up www.prebysfdn.org/stories/blog...

New paper alert! Huge congrats to my graduate student Jesse Velasco on his first author publication in physiological reports. physoc.onlinelibrary.wiley.com/doi/10.14814...