Rachel Gottschalk
@gottschalklab.bsky.social
📤 1005
📥 575
📝 12
Systems Immunology and Macrophage Signaling Assistant Professor at U Pitt
Her training is almost complete
10 days ago
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Stephanie Flores
3 months ago
49 travel grants awarded! 🎉 These early-career scientists are going to absolutely crush it at Cytokines 2025. The future of cytokine biology is looking bright with talent like this! Check out all the recipients:
cytokinesociety.org/2025/08/29/2...
#CytokineSociety
#Cytokines2025
#NextGenScientists
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Rachel Gottschalk
Pitt Department of Immunology
25 days ago
Do you know an undergrad at Pitt, Chatham University, or
@cmu.edu
who hasn't had opportunities for hands-on research? Please encourage them to apply for the Microbiology and Immunology Departments (MID) Scholars Program! Learn more and apply:
lnkd.in/eT-gYTqR
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Adrian Liston
26 days ago
Pre-print alert! And this one really is a must read for anyone that does spectral
#flowcytometry
. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
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Miriam B. Goodman, PhD
27 days ago
Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n
facultypositions.stanford.edu/en-us/job/49...
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Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
https://facultypositions.stanford.edu/en-us/job/494922
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John Chodera
27 days ago
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
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Faculty Positions
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
https://www.mskcc.org/research/ski/positions/faculty-positions
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Rachel Gottschalk
Pitt Department of Immunology
about 1 month ago
🚨 Faculty position alert! 🚨The Center for Systems Immunology (CSI) and
@pitt-immunology.bsky.social
are seeking to appoint a tenure-stream Assistant Professor. Learn more and apply:
bit.ly/3L42cGS
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The Center for Systems Immunology at the University of Pittsburgh is recruiting at the Assistant Professor level. See below for more information. Please repost!
cfopitt.taleo.net/careersectio...
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Assistant Professor - CSI
Click the link provided to see the complete job description.
https://cfopitt.taleo.net/careersection/pitt_faculty_external/jobdetail.ftl?job=24007498&tz=GMT-04%3A00&tzname=America%2FNew_York
about 1 month ago
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Ardem Patapoutian
about 1 month ago
During these uncertain times, I’m very happy to see that my institution,
@scripps.edu
has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/174756
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Rachel Gottschalk
Pitt Program in Microbiology & Immunology
about 1 month ago
Congratulations to Morgan Jackson-Strong from the
@gottschalklab.bsky.social
who will defend her thesis in a few weeks! 👏
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Rachel Gottschalk
Vaughn Cooper
about 2 months ago
Reposting, submit soon!
add a skeleton here at some point
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Shabaana Khader
about 2 months ago
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department!
microbiology.uchicago.edu
Apply here
apply.interfolio.com/174404
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/174404
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Rachel Gottschalk
Pitt Department of Immunology
about 2 months ago
Great minds think unalike: Learn how a team of immunologists, cancer researchers, telomere experts, and an organic chemist brought their different expertise together to reveal new insights into how damage to
#telomeres
can shut down
#cancer
-fighting T cells.
buff.ly/gICm1SL
(1/2)
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Adriana Forero
about 2 months ago
We are currently in the process of recruiting a technician. 🥼🐭🔬 If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
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Rachel Gottschalk
ThePatrick&WatsonLabs
about 2 months ago
If you are somehow still compelled to be a PI in the world in which we find ourselves, we'd love to have you as a colleague! Two positions in Biochemistry at Vanderbilt University.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
https://www.nature.com/naturecareers/job/12843515/assistant-professor-of-biochemistry-at-vanderbilt-university/
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Rachel Gottschalk
Pitt Department of Immunology
2 months ago
👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!
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Excellent opportunity - the Kueh lab will be recruiting at the Yale Center for Systems and Engineering Immunology this fall.
add a skeleton here at some point
3 months ago
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Christoph Bock Lab @ CeMM & MedUni Vienna
3 months ago
🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in
@cp-cellsystems.bsky.social
combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses:
www.cell.com/cell-systems...
(1/9)
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Waggoner Lab
4 months ago
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
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GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.
https://www.science.org/doi/10.1126/sciimmunol.adt0688
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Rachel Gottschalk
Kevin K. Yang 楊凱筌
4 months ago
MSA Pairformer efficiently extracts structure, protein-protein interactions, and mutation effects from MSAs by decomposing the effects of phylogeny and structural contacts.
@yoakiyama.bsky.social
Zhidian Zhang
@milot.bsky.social
@martinsteinegger.bsky.social
@sokrypton.org
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Rachel Gottschalk
Pam Ronald
4 months ago
Good news for NIH MIRA applicants.
Grants.gov
recently published the forecast notice for the reissuance of the EI/NI MIRA notice of funding opportunity. As indicated at the link, the estimated post date for the NOFO is Nov 3.
www.grants.gov/search-resul...
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Lock
https://www.grants.gov/search-results-detail/359862
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JCI insight
4 months ago
ICYMI: Parsing the STING in pulmonary hypertension— Andrew J. Bryant & team report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation:
buff.ly/DWmLPLp
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Jevin D. West
4 months ago
NIH is already feeling the effects of LLMs. A new policy was posted yesterday that limits the number of proposals that can be submitted by any one investigator.
grants.nih.gov/grants/guide...
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NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132. NIH
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-132.html
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Rachel Gottschalk
Katherine Xue
4 months ago
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601
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Junior, Assistant, or Associate Specialist – Xue Lab
University of California, Irvine is hiring. Apply now!
https://recruit.ap.uci.edu/JPF09601
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Adam MacLean
4 months ago
This is such a cool paper and dataset from lab of
@arjunraj.bsky.social
. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things...
www.biorxiv.org/content/10.1...
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Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids
Gastruloids are three-dimensional stem-cell-based models that recapitulate key aspects of mammalian gastrulation, including formation of an anterior-posterior (AP) axis. However, we do not have detail...
https://www.biorxiv.org/content/10.1101/2025.07.14.664617v1
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Ruth Franklin
4 months ago
Exciting week! Congrats to
@xuzhoulab.bsky.social
, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉
www.sciencedirect.com/science/arti...
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Regulation of inflammatory responses by pH-dependent transcriptional condensates
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…
https://www.sciencedirect.com/science/article/pii/S0092867425007354
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Thiago Carvalho
4 months ago
'In the present study, we found evidence that the brain and immune system may be central regulators of aging and longevity in humans, as aged brains are most strongly predictive of earlier mortality, and youthful brains and immune systems are uniquely predictive of longevity.'
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Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine
In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...
https://www.nature.com/articles/s41591-025-03798-1#Sec7
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Rachel Gottschalk
Juan Del Toro, PhD
4 months ago
My NIH diversity supplement was reinstated! 🥳 This is not the time to keep quiet or feel defeated by this administration. This is the time to raise hell 🔥 and be heard ✊🏽
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Ivan Zanoni
4 months ago
#WeekendRead
!
#InterferonsFriendsOrFoes
?!
@ruthfranklinlab.bsky.social
, Medzhitov, Hoagland, Rodriguez-Morales &co show
@science.org
that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
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Rachel Gottschalk
5 months ago
Our lab just completed a +6 year
#marathon
, describing for the first time that the
#microbiome
is critical for
#exercise
- induced increases in antitumor CD8 T cell immunity and improved of
#cancer
#immunotherapy
.
www.cell.com/cell/fulltex...
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900684-1
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Zach Walsh
5 months ago
Thrilled to re-share our tweetorial on Bluesky: now out in
@cp-cell.bsky.social
(🔗
tinyurl.com/3a55tsky
) - we present a framework to accelerate variant classification, diagnosis & treatment of inborn errors of immunity. A dream MD/PhD project, which has already led to the treatment of a patient.
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Rachel Gottschalk
Anshul Kundaje
5 months ago
@saramostafavi.bsky.social
(@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
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Mathew Kiang
5 months ago
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
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Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
https://ki.se/en/about-ki/jobs-at-ki/join-a-global-community-of-excellence
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Ardem Patapoutian
5 months ago
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
add a skeleton here at some point
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Adam Gracz
6 months ago
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
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Jeremy Berg
6 months ago
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
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Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
https://www.nytimes.com/interactive/2025/06/04/health/trump-cuts-nih-grants-research.html?unlocked_article_code=1.MU8.U2JL.z3BXY3hj-08t&smid=url-share
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Super cool new paper from the O'Shea lab. STAT interactions and consequences for inflammatory responses during viral infection.
www.science.org/doi/10.1126/...
6 months ago
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Rachel Gottschalk
Waggoner Lab
6 months ago
@jclinical-invest.bsky.social
preview: IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...
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Rachel Gottschalk
International Cytokine & Interferon Society (ICIS)
6 months ago
Cytokines 2025 promises to be an exceptional program! Visit
seattle.cytokinesociety.org
for the full list of invited speakers, to submit your abstract for an oral or poster presentation by June 18, or register today. You don't want to miss this year.
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Rachel Gottschalk
Ram Savan
6 months ago
Check out this multiomics study by
@naehasubramanian.bsky.social
on Lyme disease patients. It reveals localized immune responses at the site of infection, rather than in the periphery.
www.biorxiv.org/content/10.1...
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Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease
Lyme disease (LD) is growing in incidence, with nearly 500,000 cases diagnosed annually in the United States. Despite treatment, some patients experience persistent symptoms. The immune mechanisms und...
https://www.biorxiv.org/content/10.1101/2025.05.27.656061v1
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Rachel Gottschalk
Waggoner Lab
6 months ago
Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
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Vaughn Cooper
6 months ago
Heartbreaking effects of NSF, Americorps cuts to Pittsburgh’s after school programs that support and enrich our city’s kids. The need and benefits of these programs is obvious. Isn’t this what we pay taxes for? Doubt philanthropy can take over.
www.publicsource.org/federal-fund...
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Pittsburgh after-school programs left scrambling as federal funding cuts hit the region
Pittsburgh-area programs reel with recent federal grant terminations from the National Science Foundation.
https://www.publicsource.org/federal-funding-cuts-impact-pittsburgh-arts-tech-nonprofits/
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Rachel Gottschalk
BWFPATH
6 months ago
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Carolyn Bertozzi
6 months ago
David Liu
@harvard.edu
beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
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Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
https://youtu.be/8YhJM6zxYDw?si=V5iSZDdv-uwf9lui
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Scott Canna
6 months ago
"Modeling the
#HLH
immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death" We're pretty excited about this one.
doi.org/10.1182/bloo...
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Rachel Gottschalk
Denis Wirtz
7 months ago
We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free:
research.jhu.edu/rdt/funding-...
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Ivan Zanoni
7 months ago
#WeekendRead
!
#EveryCellIsAnImmuneCell
! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into
#lung
interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
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Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
https://www.science.org/doi/10.1126/sciimmunol.adr4977
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Ivan Zanoni
7 months ago
#EpigeneticPower
! Ivashkiv, Mishra &co show
@natimmunol.bsky.social
that anti-inflammatory IL-10 epigenetically silence IRF1 & IRF5 gene transcription by decreasing H3K27ac & chromatin accessibility, thus preventing sustained
#interferons
& IL6/TNF signaling!
www.nature.com/articles/s41...
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IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms - Nature Immunology
Ivashkiv and colleagues show that IL-10 inhibits the expression and DNA binding of IRF1 and IRF5, two transcription factors that have an amplifying role in the induction of inflammatory NF-κB target g...
https://www.nature.com/articles/s41590-025-02137-3
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Saez-Rodriguez Group
7 months ago
We have an opening for a PhD/Postdoc in Spatial Omics for Cardiology in Heidelberg 🫀
#job
#academicjob
#phd
#postdoc
#cadiology
👇
jobrxiv.org/job/heidelbe...
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PhD/Postdoc in Spatial Omics for Cardiology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
https://jobrxiv.org/job/heidelberg-university-and-heidelberg-university-hospital-27778-phd-postdoc-in-spatial-omics-for-cardiology/
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Trends in Immunology
7 months ago
The five senses of immunity
#immunology
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The five senses of immunity
A genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behavioral, shared and population level immunity redefining our understanding of the ways organisms communicate among and defend themselves.
http://dlvr.it/TKFJyJ
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