How does acidity affect #ImmuneCells? The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4. 🥼 Abstract in @cellpress.bsky.social#ImmuneCells#BRD4https://bit.ly/3IZDAhP ✏️ Press release: https://on.bchil.org/48rhZtf

Super excited to see our recent @cellcellpress.bsky.social paper featured in a Life Metabolism preview! Huge thanks to Christoopher Glass @ucsdmedschool.bsky.social for the thoughtful highlight. 🔗 academic.oup.com/lifemeta/adv... #inflammation #macrophage #chromatin #pH #biomolecularcondensates

TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut. www.cell.com/cell/abstrac...

congratulations to @virusesimmunity.bsky.social @brangwynnelab.bsky.social!

Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...

Been waiting for this from my dear friends: Macrophage derived growth factor promotes epithelial proliferation for repair when lung is under inflammatory damage 🔥🔥🔥 huge congrats to @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social and the team! 🎉👏🏼🍾 @harvard.edu @harvardmed.bsky.social

#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇

pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪ @xuzhoulab.bsky.social www.cell.com/cell/fulltex... www.nature.com/articles/s41... www.preprintclub.com/preprint-rev... @preprintclub.bsky.social

Thank you for those who have a conscientious!

Schumer advocated for budget CR today, essentially giving White House decision making power on AMERICAS budget. Cutting Medicaid, social security, and SCIENCE would be no problem. Call and email your senator now if think this is a horrible idea, especially if you live in New York www.govtrack.us

Amazing article www.sensible-med.com/p/the-nih-is...

If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus? www.nytimes.com/2025/02/14/o...

The perk of a wildly successful research enterprise is knowledge--and medical innovation. The cost of successful research is the forever argument over credit for discoveries (and revenue). How about we all invest in research, so we can keep living (and arguing)?

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

If this is not reversed it is going to destroy the ability of universities to support biomedical research and it will completely shut down private research institutes like the Salk Institute, the Fred Hutchinson Cancer Research Center, Scripps, and many others.

Despite all kinds of chaos, nothing beats a hotpot celebration of Lunar New Year with my lab family! Happy the year of snake! Year of slytherin! 🎉🎊🎆🍲

Heroic effort by @prywes.bsky.social tackling one of the most difficult protein! 👏🏼

Happy holidays to everyone! Just celebrated 2024 with the amazing group of people who made me want to go to work everyday, full of surprises and excitement! Looking forward to 2025 of Zhou lab #labholiday @bostonchildrens.bsky.social @harvardmed.bsky.social