by Aglaia Skolariki & @eileenparkes.bsky.social

by Alisa Iakupova & @theonlylabever.bsky.social

by @shelley-herbrich.bsky.social & @pamsharmamdphd.bsky.social

Today at #PreprintHub2, Meredith from Virginia will present a #preprint by Cecilia Pessoa Rodrigues from the Daniel Regan-Komito Lab, with the title "IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling" 🔬🧬 www.biorxiv.org/content/10.1...

Also tomorrow in #PreprintHub1, Mehdi Chaib from MD Anderson will present a #preprint from the DuPage lab about how intratumoral Treg ablation is sufficient to mediate tumor control without systemic autoimmunity. www.biorxiv.org/content/10.1...

Tomorrow in #preprintHub1, Meredith Ramba from Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells. biorxiv.org/content/10.1...

Tomorrow, @kiel_olumuyide from @IcahnMountSinai will present a #preprint by Dr.Zhejie Li from @Zhu_Lab titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity." www.biorxiv.org/content/10.1...

Tomorrow at #PreprintHub2, @lmgail.bsky.social from @cemm.oeaw.ac.at and Lea Heinzl from Uni Wien/MUW will present a #preprint by Thomas N. Burn from Professor Laura Mackay Lab: "Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours" www.biorxiv.org/content/10.1...

Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social www.biorxiv.org/content/10.1...

Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS www.biorxiv.org/content/10.1...

Tomorrow at #PreprintHub2, Raisa Brito from @mdc-berlin.bsky.social will present a #preprint by Prof. Dr. Karsten Kretschmer titled “Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice”

Today from MD Anderson Cancer Center, Dr. Priyanshu Srivastava presented a preprint about tumor instrinsic regulation of PD-L1 and type I IFN by the mitochondrial citrate carrier SLC25A1 @Georgetown #Avantaggiatilab

Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells

Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!

Today at #PreprintHub2, Teresa Neuwirth from @cemm.oeaw.ac.at will present a #preprint by @retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬 www.biorxiv.org/content/10.1...

Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development. www.biorxiv.org/content/10.1...

Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens. www.biorxiv.org/content/10.1...

Tomorrow in #PreprintHub2, @alisaiakupova.bsky.social from ‪@mdc-berlin.bsky.social‬ will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷 Preprint: www.researchsquare.com/article/rs-4...

pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪ @xuzhoulab.bsky.social www.cell.com/cell/fulltex... www.nature.com/articles/s41... www.preprintclub.com/preprint-rev... @preprintclub.bsky.social

🙏

Amitava Sinha via the @preprintclub.bsky.social‬ wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...

Another Journal Club article from @preprintclub.bsky.social - Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow #immunosky #cancersky rdcu.be/euBTD

Take a look at our feedback 👉👈 www.preprintclub.com/preprint-rev...

This semester’s #preprinthub2 club, led by Carolina Mangana & Alex Deltedesco has concluded with a #preprint on how human chronic inflammation is orchestrated by spatially restricted inflammation-activated #DCs. 🎻🫨🚧 #immunosky www.biorxiv.org/content/10.1...

Happy to share with you another excellent preprint highlight. #immunosky

The Preprint club community is growing! Take a look if you’re interested in #genomics.

Check out our feedback on this #preprint 📚 📚📚 www.preprintclub.com/preprint-rev...

In our Wednesday #DoubleFeatureEvent Toronto’s own Arthur Mortha will present a #preprint from @xuzhoulab.bsky.social about the role of pH in environment-dependent control of #inflammation. 🔥🔥🔥 www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 MD Anderson’s Tiantian Zhou will present a #preprint about the way AI-guided CAR designs and AKT3 degradation can synergize to enhance bispecific and trispecific CAR-T cell persistence and overcome #antigen escape. 💻 3️⃣ 🚗 www.biorxiv.org/content/10.1...

Today, in #preprinthub2 Amitava Sinha will present a #preprint from Angelo lab @stanfordmedicine.bsky.social on how the immunometabolic topography of TB granulomas governs cellular organization and bacterial control. 🦠🚦🙊 #immunosky www.biorxiv.org/content/10.1...

In our Wednesday #DoubleFeatureEvent Oxford’s own Meghna Shajil will present a #preprint about how hormetic elevation of taurine restrains #inflammaging by deactivation of the NLRP3 inflammasome. 🐂 🧓 3️⃣ www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 Mount Sinai’s own Yu-Chan Chih will present a #preprint about redirecting cytomegalovirus immunity against pancreatic cancer for immunotherapy. ⤴️🫧🦀 www.biorxiv.org/content/10.1...

Today, Michelle Montoya from @uvaimmunology.bsky.social will present a #preprint on how Serpine1 plays a critical role in #Th17 cell differentiation and #psoriasis pathogenesis. 🐭🙌☝️ www.biorxiv.org/content/10.1...

Today, in #preprinthub2 @cleeterichter.bsky.social will lead a discussion of a #preprint from @santoshvardhana.bsky.social @mskcancercenter.bsky.social on MEK-dependent bioenergetic demand driving terminal CD8+ T cell exhaustion. 🫩🍰💥 #immunosky www.biorxiv.org/content/10.1...

Check out our feedback on this #preprint 📚 📚📚 www.preprintclub.com/preprint-rev...

Tomorrow, in #PreprintClubHub1 Toronto’s own Sai Chung will present a #preprint about the way liver transplant rejection features #memory cell priming, spatially differentiated #networks and novel drug #targets. 🤔 📶 🎯 www.biorxiv.org/content/10.1...

Check out our feedback on this #preprint 📚 📚📚 www.preprintclub.com/preprint-rev...

In our #DoubleFeatureEvent, MD Anderson’s Adam Grippin will present a #preprint from ‪@carolynbertozzi.bskyverified.social‬ about how mapping the nanoscale organization of the human cell surface proteome reveals functional associations and surface antigen clusters. www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 Oxford’s own Anjum Aktar will present a #preprint about the way #mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens. 🪩🛑🍽️ www.biorxiv.org/content/10.1...

Today, in #preprinthub2 Palina @viennabiocenter.bsky.social will present a #preprint from Harry N. White & @annecorcoran.bsky.social @babrahaminst.bsky.social on how VH-replacement shapes the antibody repertoire by targeting non-pairing heavy-chains. 🔎🪢🐁 www.biorxiv.org/content/10.1...

NEW Journal Club article from @preprintclub.bsky.social discusses @biorxiv-immuno.bsky.social preprint by Ellul et al. showing that maternal immune activation in mice drives regulatory T cell dysfunction in offspring and autism-like behaviours rdcu.be/eo65K

Today, in #preprinthub2 Sarah Wideman will present a #preprint from @virusesimmunity.bsky.social about cutaneous #lupus featuring specialized stromal niches and altered retroelement expression. 🤲🏻🐺🦠 www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 Mount Sinai’s Rachel Geltman ‪@rachelgeltman.bsky.social will present a #preprint from @asmita_panthi about the way alternate isoforms of IRF7 differentially regulate #interferon expression to tune response to viral infection. 7️⃣ 🎶 🤒 www.biorxiv.org/content/10.1...

Today, in #preprinthub2 Raisa Brito @mdc-berlin.bsky.social will present a #preprint from @inflammasomelab.bsky.social on how caspase-1 self-terminates protease activity to enforce homeostasis and prevent #inflammasome driven diseases. ✂️🧯🐭 #immunosky www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 Toronto’s own Sara Lamorte will present a #preprint from @amycfanphd.bsky.social & @maxkrummel.bsky.social about submicron-sampling of living cells by #macrophages. 🔍 🤏 🍽️ www.biorxiv.org/content/10.1...

Today, in #preprinthub2 Kveta will discuss a #preprint from Peter Morawski lab @benaroyaresearch.bsky.social about how T cells promote distinct transcriptional programs of cutaneous inflammatory disease in #keratinocytes and dermal fibroblasts.🖖🕹️📱 #immunosky www.biorxiv.org/content/10.1...

In our Wednesday #DoubleFeatureEvent, Oxford’s own Tianming Zhao will present a #preprint about the way IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma. 🔞🚗 🧠 www.biorxiv.org/content/10.1...

Tomorrow, in #PreprintClubHub1 Mount Sinai’s Theresa Chu will present a #preprint about the identification of IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signalling for engineered T cell therapy. 9️⃣ 🎃 👕 www.biorxiv.org/content/10.1...

NEW Preprint Watch from Annette Wu & @wenjiang-nano.bsky.social @preprintclub.bsky.social reporting on @biorxiv-immuno.bsky.social preprint by @colinraposo.bsky.social et al. showing that checkpoint blockade drives expansion of exhausted T cell clones that develop functional memory rdcu.be/ek1kY

Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....